Combination of Transcriptomics and Proteomics Reveals Differentially Expressed Genes and Proteins in the Skin of EDAR Gene-Targeted and Wildtype Cashmere Goats

April 2023 in “ Animals ”

Guizhen Gao, Hao Fei, Lei Zhu, Guo‐Qing Jiang, Wei Yan, Jie Liu, Dongjun Liu

EDAR gene hair follicle growth transcriptomics proteomics differentially expressed genes differentially expressed proteins cellular processes binding modules catalytic modules EDAR hair growth gene expression protein expression

Studysummary This study utilized EDAR gene-targeted cashmere goats to identify 732 differentially expressed genes and 140 proteins associated with abnormal hair growth, providing insights into the regulatory mechanisms of cashmere follicle development.

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This study found that EDA and EDAR are expressed throughout cashmere goat fetal development and play a critical role in hair follicle formation by influencing gene expression in fibroblasts and epithelial cells.

research Comparative Study on Seasonal Hair Follicle Cycling by Analysis of the Transcriptomes from Cashmere and Milk Goats

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research Generation of Cashmere Goats Carrying an EDAR Gene Mutant Using CRISPR-Cas9-Mediated Genome Editing

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research High-Throughput Sequencing of Hair Follicle Development-Related MicroRNAs in Cashmere Goat at Various Fetal Periods

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