Research Progress on the Application of Stem Cells in Hair Regeneration

December 2024 in “ Highlights in Science Engineering and Technology ”

Xiaohuan Mu

hair follicle stem cells HFSCs stem cells hair regeneration JAK inhibitors physical stimulation techniques

TLDR Stem cells show promise for hair regrowth, but challenges remain.

Hair follicle stem cells (HFSCs) hold significant promise for hair regeneration due to their self-renewal and differentiation capabilities, making them a potential new therapy for hair loss. They are easy to isolate and culture, which is advantageous for clinical applications. The document discusses various methods to stimulate hair growth, such as JAK inhibitors and physical stimulation techniques, which activate HFSCs and promote hair growth. Despite their potential, challenges like effective expansion, survival rates, and functional recovery in vivo, as well as ethical and regulatory issues, need to be addressed. Further research is necessary to understand HFSC mechanisms and improve their application in hair regeneration therapies.

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Research cited in this study

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research The Rise of Induced Pluripotent Stem Cell Approach to Hair Restoration

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Using special stem cells, we can create new hair follicles, potentially making hair restoration easier and more affordable.

research Stimulation of Hair Growth by Small Molecules That Activate Autophagy

88 citations, June 2019 in “Cell reports”

Certain small molecules can promote hair growth by activating a cellular cleanup process called autophagy.

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research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

136 citations, May 2019 in “Cells”

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

research JAK Inhibitors for Treatment of Alopecia Areata

63 citations, July 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

JAK inhibitors can effectively reverse hair loss in people with alopecia areata.

research External Light Activates Hair Follicle Stem Cells Through Eyes Via an ipRGC–SCN–Sympathetic Neural Pathway

61 citations, June 2018 in “Proceedings of the National Academy of Sciences of the United States of America”

Light can turn on hair growth cells through a nerve path starting in the eyes.

A Pilot Split-Scalp Study of Combined Fractional Radiofrequency Microneedling and 5% Topical Minoxidil in Treating Male Pattern Hair Loss

research A Pilot Split-Scalp Study of Combined Fractional Radiofrequency Microneedling and 5% Topical Minoxidil in Treating Male Pattern Hair Loss

25 citations, June 2018 in “Clinical and Experimental Dermatology”

Combined microneedling and minoxidil improves hair growth more than minoxidil alone.

research The Basic Mechanism of Hair Growth Stimulation by Adipose-Derived Stem Cells and Their Secretory Factors

52 citations, September 2017 in “Current Stem Cell Research & Therapy”

Adipose-derived stem cells can help treat hair loss.

research Lactate Dehydrogenase Activity Drives Hair Follicle Stem Cell Activation

202 citations, August 2017 in “Nature cell biology”

Lactate production is important for activating hair growth stem cells.

research Aging in Hair Follicle Stem Cells and Niche Microenvironment

38 citations, June 2017 in “The Journal of Dermatology”

Aging in hair follicle stem cells leads to hair graying, thinning, and loss.

research Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis

242 citations, February 2016 in “Science”

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.

Hair Growth Promoting Effect of Dermal Papilla-Like Tissues from Canine Adipose-Derived Mesenchymal Stem Cells Through Vascular Endothelial Growth Factor

research Hair Growth Promoting Effect of Dermal Papilla-Like Tissues from Canine Adipose-Derived Mesenchymal Stem Cells Through Vascular Endothelial Growth Factor

8 citations, January 2016 in “Journal of Veterinary Medical Science”

Lab-made tissues from dog fat stem cells can help grow hair by releasing a growth factor.

research Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth

159 citations, October 2015 in “Science Advances”

Blocking JAK-STAT signaling can lead to hair growth.

research Inhibiting Janus Kinases to Treat Alopecia Areata

52 citations, September 2014 in “Nature medicine”

JAK inhibitors might help treat alopecia areata.

research Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition

701 citations, August 2014 in “Nature medicine”

Alopecia areata can be reversed by JAK inhibitors, promoting hair regrowth.

research Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1, and Sfrp4

75 citations, March 2014 in “Journal of Investigative Dermatology”

Aging mice have slower hair regeneration due to changes in signal balance, but the environment, not stem cell loss, controls this, suggesting treatments could focus on environmental factors.

research Stress-Induced Production of Chemokines by Hair Follicles Regulates the Trafficking of Dendritic Cells in Skin

286 citations, June 2012 in “Nature Immunology”

Hair follicles help attract immune cells to the skin during stress.

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research Tissue Engineering and Regeneration of the Human Hair Follicle in Androgenetic Alopecia: Literature Review

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