MTORC1 Activity Negatively Regulates Human Hair Follicle Growth and Pigmentation

    May 2023 in “ EMBO reports ”
    Takahiro Suzuki, Jérémy Chéret, Fernanda Dinelli Scala … Ralf Paus
    Studysummary In this study with organ-cultured human scalp hair follicles, high mTORC1 activity correlated with gray/white hair and reduced pigmentation, while inhibiting mTORC1 with rapamycin increased hair growth and pigmentation, suggesting mTORC1 inhibition could be a strategy for treating hair depigmentation and loss.
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    Research cited in this study 29

    1. MTORC1 Activity Negatively Regulates Human Hair Follicle Growth and Pigmentation EMBO reports · 2023
    2. Revisiting the Role of Melatonin in Human Melanocyte Physiology: A Skin Context Perspective Journal of pineal research · 2022
    3. Resident Human Dermal Gamma Delta T-Cells Operate as Stress Sentinels: Lessons from the Hair Follicle Journal of Autoimmunity · 2021
    4. Udp-GlcNAc-1-Phosphotransferase Is A Clinically Important Regulator Of Human And Mouse Hair Pigmentation Journal of Investigative Dermatology · 2021
    5. Hair Follicle Chemosensation: TRPM5 Signaling Is Required for Anagen Maintenance Journal of Investigative Dermatology · 2021
    6. Dermal Adipose Tissue Secretes HGF to Promote Human Hair Growth and Pigmentation Journal of Investigative Dermatology · 2021
    7. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
    8. Frontiers in Alopecia Areata Pathobiology Research ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology · 2019
    9. CDK4/6 Inhibition Mitigates Stem Cell Damage in a Novel Model for Taxane-Induced Alopecia EMBO Molecular Medicine · 2019
    10. Olfactory Receptor OR2AT4 Regulates Human Hair Growth Nature Communications · 2018
    11. Identifying Novel Strategies for Treating Human Hair Loss Disorders: Cyclosporine A Suppresses the Wnt Inhibitor, SFRP1, in the Dermal Papilla of Human Scalp Hair Follicles PLOS Biology · 2018
    12. Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases Trends in Molecular Medicine · 2018
    13. Human Hair Follicle Organ Culture: Theory, Application, and Perspectives Experimental Dermatology · 2015
    14. The Peripheral Clock Regulates Human Pigmentation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2014
    15. Neuroendocrinology of the Hair Follicle: Principles and Clinical Perspectives Trends in Molecular Medicine · 2014
    16. An Overview of Alopecias Cold Spring Harbor Perspectives in Medicine · 2014
    17. Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche The Journal of Pathology · 2013
    18. Topobiology of Human Pigmentation: P-Cadherin Selectively Stimulates Hair Follicle Melanogenesis ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2013
    19. Melanocyte Stem Cells: A Melanocyte Reservoir in Hair Follicles for Hair and Skin Pigmentation Pigment Cell & Melanoma Research · 2011
    20. A Neuroendocrinological Perspective on Human Hair Follicle Pigmentation Pigment Cell & Melanoma Research · 2010
    21. The Cell Biology of Human Hair Follicle Pigmentation Pigment cell & melanoma research · 2010
    22. Methods in Hair Research: How to Objectively Distinguish Between Anagen and Catagen in Human Hair Follicle Organ Culture Experimental Dermatology · 2009
    23. The Silver Locus Product (Silv/gp100/Pmel17) as a New Tool for the Analysis of Melanosome Transfer in Human Melanocyte–Keratinocyte Co-Culture Experimental dermatology · 2008
    24. Towards A Free Radical Theory Of Graying: Melanocyte Apoptosis In The Aging Human Hair Follicle As An Indicator Of Oxidative Stress Induced Tissue Damage ˜The œFASEB journal · 2006
    25. Detection of Functionally Active Melanocortin Receptors and Evidence for an Immunoregulatory Activity of Alpha-Melanocyte-Stimulating Hormone in Human Dermal Papilla Cells Endocrinology · 2005
    26. Human Hair Follicles Display a Functional Equivalent of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Synthesize Cortisol The FASEB Journal · 2005
    27. Hair Follicle Pigmentation: Mechanisms and Factors Influencing Melanin Production ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2005
    28. Bone Morphogenetic Protein Signaling Controls Hair Pigmentation Through Cross-Talk With the Melanocortin Receptor-1 Pathway Proceedings of the National Academy of Sciences · 2004
    29. The Biology of Hair Follicles The New England Journal of Medicine · 1999