Mammalian Target of Rapamycin Complex 1 (mTORC1) May Modulate the Timing of Anagen Entry in Mouse Hair Follicles

    November 2012 in “ Experimental dermatology ”
    Antonia J. Kellenberger, Miyuki Tauchi
    Studysummary This study suggests that mTORC1 may play a role in regulating the timing of hair growth cycle phases, particularly the initiation of the anagen phase.
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    Research cited in this study 10

    1. Akt2 and SGK3 Are Both Determinants of Postnatal Hair Follicle Development The FASEB Journal · 2009
    2. Molecular Pathways Involved in Hair Follicle Tumor Formation: All About Mammalian Target of Rapamycin? Experimental Dermatology · 2009
    3. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    4. Folliculin Encoded by the BHD Gene Interacts with a Binding Protein, FNIP1, and AMPK, and Is Involved in AMPK and mTOR Signaling Proceedings of the National Academy of Sciences · 2006
    5. Two Distinct Signaling Pathways in Hair Cycle Induction: Stat3-Dependent and Independent Pathways Proceedings of the National Academy of Sciences of the United States of America · 2000
    6. WNT Signaling in the Control of Hair Growth and Structure Developmental biology · 1999
    7. Increased Vibrissa Growth in Transgenic Mice Expressing Insulin-Like Growth Factor 1 ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1999
    8. Effects of Immunosuppressive Peptidyl-Prolyl Cis-Trans Isomerase (PPIase) Inhibitors, Cyclosporin A, FK506, Ascomycin, and Rapamycin, on Hair Growth Initiation in Mice: Immunosuppression Is Not Required for New Hair Growth Journal of Dermatological Science · 1995
    9. Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles Differentiation · 1994
    10. Critical Stages of Hair Development and Pigmentation in the Mouse Physiological zoology · 1951

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