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    PBX Homeobox 1 Enhances Hair Follicle Mesenchymal Stem Cell Proliferation and Reprogramming Through Activation of the AKT/Glycogen Synthase Kinase Signaling Pathway and Suppression of Apoptosis

    August 2019 in “ Stem Cell Research & Therapy ”
    Yixu Jiang, Feilin Liu, Fei Zou … Jinyu Liu
    Studysummary This study found that PBX1 enhances the proliferation and reprogramming of hair follicle mesenchymal stem cells by activating the AKT/GSK3β signaling pathway, promoting NANOG expression, and inhibiting apoptosis.
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    Research cited in this study 6

    1. Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated With Upregulation of Cyclin D1 and Downregulation of p16 Stem Cells and Development · 2016
    2. From Hair to Heart: Nestin-Expressing Hair-Follicle-Associated Pluripotent Stem Cells Differentiate to Beating Cardiac Muscle Cells Cell Cycle · 2015
    3. Transdifferentiation of Human Hair Follicle Mesenchymal Stem Cells into Red Blood Cells by OCT4 Stem cells international · 2015
    4. Engineered Hair Follicle Mesenchymal Stem Cells Overexpressing Controlled-Release Insulin Reverse Hyperglycemia in Mice with Type 1 Diabetes Cell transplantation · 2014
    5. Induced Pluripotent Stem Cells From Human Hair Follicle Mesenchymal Stem Cells Stem Cell Reviews and Reports · 2012
    6. Multipotent Nestin-Positive, Keratin-Negative Hair-Follicle Bulge Stem Cells Can Form Neurons Proceedings of the National Academy of Sciences · 2005