January 202573
A review concluded dutasteride for pattern hair loss outperformed finasteride with similar safety, though it reduced sperm count and motility, so men with pregnant partners should avoid it. A meta-analysis found adding low-level laser to minoxidil did not significantly improve hair count or diameter over minoxidil alone. A trial found topical dutasteride with fractional CO2 laser improved androgenetic alopecia more than laser alone. A randomized trial reported sublingual minoxidil increased hair fibre diameter at higher doses, suggesting reversal of follicle miniaturization. A prospective study found oral minoxidil raised serum VEGF, improved hair count and diameter, and reduced shedding. A meta-analysis reported botulinum toxin injections significantly increased hair count, with good safety in mostly small studies. A Mendelian randomization study linked genetically predicted pattern baldness to lower prostate cancer risk but higher benign prostatic hyperplasia risk. A long-term study found ritlecitinib in alopecia areata maintained regrowth, with mostly mild adverse events but rare infections and cardiovascular events.
- Efficacy and safety of dutasteride in the treatment of alopecia: a comprehensive review A review concludes dutasteride outperforms finasteride for pattern hair loss with similar safety, but it can reduce sperm count and motility, and men whose partners are pregnant should avoid it.
- Exploring the hair loss risk in glucagon‐like peptide‐1 agonists: Emerging concerns and clinical implications A commentary highlights a potential link between GLP-1 agonists semaglutide and tirzepatide and alopecia risk, stressing that further investigation and patient awareness are needed.
- Glucagon-like peptide-1 receptor agonist medications and hair loss: A retrospective cohort study a retrospective cohort study examines whether GLP-1 receptor agonist medications are associated with hair loss.
- Comparative efficacy of minoxidil alone versus minoxidil combined with low-level laser therapy in the treatment of androgenic alopecia: a systematic review and meta-analysis A meta-analysis of four trials found adding low-level laser therapy to minoxidil did not significantly improve hair count or diameter over minoxidil alone.
- Comparative study between fractional CO2 laser alone versus fractional CO2 laser combined with topical dutasteride in treatment of male androgenic alopecia In a 30-man trial, adding topical dutasteride to fractional CO2 laser sessions improved androgenetic alopecia more than laser alone.
- Sublingual Minoxidil Increases Fibre Diameter in Male Androgenetic Alopecia. - A proxy for Reversal of Hair Follicle Miniaturization. In a randomized trial, sublingual minoxidil at 1.35 and 4.05 mg, but not 0.45 mg, significantly increased hair fibre diameter, suggesting reversal of follicle miniaturization.
- Effects of oral minoxidil on serum VEGF and hair regrowth in androgenetic alopecia In a 50-person prospective study, 1 mg daily oral minoxidil raised serum VEGF and improved hair count and diameter while reducing shedding.
- Treatment of Androgenetic Alopecia with Low Dose Oral Minoxidil Monotherapy Compared to Combination Therapy with Dutasteride or Finasteride low-dose oral minoxidil alone was compared with combination therapy using dutasteride or finasteride for androgenetic alopecia.
- Bletilla striata polysaccharide-based dissolving microneedle patch integrated with nanoparticles for promoting hair regrowth A tofacitinib-loaded dissolving microneedle patch increased hair follicle numbers in vivo with less drug than daily topical tofacitinib, reducing dosing frequency.
- Co-delivery of minoxidil and finasteride via ionic liquid and cyclodextrin-assisted in situ thermosensitive hydrogel for synergistic treatment of androgenic alopecia In mice, a thermosensitive hydrogel co-delivering minoxidil and finasteride improved follicle targeting and hair regrowth versus standard formulations.
- Chemotherapy-Induced Alopecia in Ovarian Cancer: Incidence, Mechanisms, and Impact Across Treatment Regimens A scoping review found platinum compounds, taxanes, and topoisomerase inhibitors most strongly cause chemotherapy-induced alopecia in ovarian cancer, with combination regimens posing highest risk.
- Gas-propelled anti-hair follicle aging microneedle patch for the treatment of androgenetic alopecia In mice, a gas-propelled microneedle patch delivering antioxidant nanoparticles rejuvenated senescent follicle cells and improved hair coverage.
- Long‐term safety and efficacy of ritlecitinib in adults and adolescents with alopecia areata and at least 25% scalp hair loss: Results from the ALLEGRO‐LT phase 3, open‐label study In a phase 3 long-term study, ritlecitinib maintained hair regrowth over 24 months in alopecia areata; 86% had adverse events, mostly mild, with rare infections and cardiovascular events.
- Effects and Safety of Botulinum Toxin Injection in Treatment of Androgenetic Alopecia: A Meta-analysis and Systematic Review A meta-analysis of eight studies found botulinum toxin injections significantly increased hair count in androgenetic alopecia, with good reported safety in mostly small studies.
- Effect of amniotic fluid on hair follicle growth In a rat hair-loss model, irradiated human amniotic fluid increased hair follicle density and anagen transition while shifting macrophages to an anti-inflammatory state.
- Using patient preference to inform ritlecitinib dose selection for alopecia areata treatment A discrete-choice survey of 201 alopecia areata patients found most would accept modest added infection, cancer, and clot risks for ritlecitinib 50 mg over 30 mg to gain more hair regrowth.
- Low‐dose oral minoxidil in alopecia: evaluating blood pressure changes in patients with abnormal blood pressure—a retrospective study a retrospective study evaluated blood pressure changes in patients with abnormal blood pressure taking low-dose oral minoxidil.
- Fractional CO<sub>2</sub> Laser and Minoxidil in the Treatment of Alopecia Areata, A Comparative Study In a 150-patient study, fractional CO2 laser plus minoxidil 5% beat minoxidil alone for alopecia areata regrowth, with minimal transient side effects.
- Insights of prostate diseases risk among patients with male pattern baldness: a mendelian randomized study A Mendelian randomization study found genetically predicted male pattern baldness slightly lowers prostate cancer risk but raises benign prostatic hyperplasia risk, suggesting prostate screening value.
- Baricitinib for the treatment of severe alopecia areata: results from a 52-week multicenter retrospective real-world study In a real-world study of 96 patients with severe alopecia areata, 61.5% achieved significant scalp regrowth after 52 weeks of baricitinib, with no significant safety issues.
- A Randomized, Double‐Blind, Placebo‐Controlled Study to Evaluate the Safety and Efficacy of a Nutraceutical Supplement With Standardized Botanicals in Males With Thinning Hair A randomized placebo-controlled trial tested a botanical nutraceutical targeting hormonal, stress, and metabolic factors in men with thinning hair, extending prior results in women.
- Treatment of alopecia areata with JAK inhibitors: a review of the literature A review finds JAK inhibitors such as baricitinib and deuruxolitinib produce significant regrowth in alopecia areata, though long-term safety data remain limited.
- Clinical Efficacy and Safety of Baricitinib in Patients With Alopecia Areata in Korea In a real-world Korean study of 117 alopecia areata patients, baricitinib significantly improved SALT scores by week 36 with mostly mild-to-moderate adverse reactions.
- Dietary measures as an adjunctive therapy in alopecia areata: a scoping review A scoping review identified 14 articles on dietary measures and hair regrowth in alopecia areata.
- High-Frequency Ultrasonography in Hair and Nail Disorders—How It May Be Helpful A review presents how high-frequency ultrasonography can visualize hair follicles and nail units for assessing disease extent and monitoring treatment.
- Comparing the Efficacy of Combined Intralesional Triamcinolone Acetonide With Topical Calcipotriol Versus Intralesional Triamcinolone Acetonide Monotherapy in Scalp and Beard Alopecia Areata: Results From a Randomized Single-Blinded Clinical Trial In a randomized trial, adding topical calcipotriol to intralesional triamcinolone improved scalp alopecia areata regrowth but not beard patches, with less skin atrophy.
- Relapse of Alopecia Areata Responders After Tofacitinib Withdrawal: A Retrospective Study of 59 Patients A retrospective study of 59 alopecia areata patients who responded to tofacitinib examines relapse after treatment withdrawal.
- Emotional burden and current management practices in pediatric alopecia areata: An online survey among physicians an online physician survey examines emotional burden and current management practices in pediatric alopecia areata.
- Trichoscopic Features of Lichen Planopilaris versus Frontal Fibrosing Alopecia: A Systematic Review A systematic review identified distinct trichoscopic features differentiating lichen planopilaris from frontal fibrosing alopecia, aiding diagnosis of these scarring hair loss conditions.
- Predictive factors for treatment responses to baricitinib in severe alopecia areata: A retrospective, multivariate analysis of 70 cases from a single center In 70 severe alopecia areata patients, shorter disease duration, lower baseline SALT score, female sex and prior steroid pulse predicted better baricitinib response.
- Combination of oral minoxidil and bicalutamide for the treatment of female pattern hair loss in adolescents oral minoxidil combined with bicalutamide was used to treat female pattern hair loss in adolescents.
- Exploring the Physicochemical Compatibility of Minoxidil in Combination with Different Active Pharmaceutical Ingredients in Ready-to-use Vehicles for Alopecia Treatment A lab study found minoxidil compounded with various actives in TrichoSol and TrichoFoam vehicles stayed stable for 90–180 days at room temperature.
- An update on nanocarriers for follicular-targeted drug delivery for androgenetic alopecia topical treatment A review finds nanocarriers could target topical drugs to hair follicles, but poor controls and missing follicle measurements prevent firm conclusions.
- Exploring the effect of hsa-miR-19b-3p on IL-1R1 expression and serum levels in alopecia areata Elevated hsa-miR-19b-3p and IL-1R1 levels correlate with alopecia areata severity and show potential as diagnostic markers in a case-control study.
- Innovating alopecia treatment: nanostructured lipid carriers as advanced delivery platforms A review explores nanostructured lipid carriers as delivery platforms for minoxidil, finasteride, and plant compounds to improve alopecia treatment penetration and efficacy.
- Nanoparticle Adjuvants Incorporating Haptens Drive Potent Immune Tolerance to Accelerate Hair Regrowth In a mouse alopecia areata model, nanoparticles co-delivering diphenylcyclopropenone and rapamycin induced immune tolerance and promoted hair regrowth.
- Baricitinib for the Treatment of Moderate-to-Severe Alopecia Areata baricitinib was used to treat moderate-to-severe alopecia areata.
- Population exposure–response analysis of the effect of ritlecitinib on eyebrow assessment and eyelash assessment in patients with alopecia areata Population modeling supported the 50 mg ritlecitinib dose for eyebrow and eyelash regrowth in alopecia areata, with exposure-response relationships differing across efficacy endpoints.
- Psychological Outcomes After Hair Transplant in Women With Androgenetic Alopecia psychological outcomes were assessed in women with androgenetic alopecia after hair transplant.
- Identifying effective immune biomarkers in alopecia areata diagnosis based on machine learning methods Machine learning identified three hub genes as diagnostic markers for alopecia areata with high predictive accuracy in a bioinformatics study.
- The exposome impact on hair health: non-pharmacological management. Part II⋆ A narrative review outlines non-drug strategies to protect hair from exposome factors such as UV, pollution and chemical treatments.
- Pathogenesis of paradoxical alopecia areata during dupilumab therapy: What is known and unknown A review examines paradoxical alopecia areata worsening during dupilumab therapy, finding higher baseline IgE levels predict better response while Th2 skewing may explain adverse effects.
- Elevating Dermatology Beyond Aesthetics: Perinatal-Derived Advancements for Rejuvenation, Alopecia Strategies, Scar Therapies, and Progressive Wound Healing a review of perinatal-derived advancements for rejuvenation, alopecia strategies, scar therapies, and wound healing.
- Healthy individuals genetically at-risk for the development of Pemphigus vulgaris or Alopecia areata share disease-like cytokine dysregulation Healthy individuals genetically at-risk for alopecia areata share disease-like cytokine dysregulation patterns with patients, suggesting inherited immune imbalances.
- Frontal Fibrosing Alopecia Part II: Etiopathogenesis and Management A review of frontal fibrosing alopecia discusses genetic associations, environmental triggers like cosmetics, and treatment strategies including hydroxychloroquine, dutasteride and topical therapies.
- Sphingolipid metabolism orchestrates establishment of the hair follicle stem cell compartment In mouse epidermis, deleting ceramide synthase 4 disrupts hair follicle stem cell niche formation via altered ceramides and hyperactive Wnt signaling.
- Comorbid Bronchial Asthma, Atopic Dermatitis and Hashimoto's Thyroiditis Are Risk Factors for Early‐Onset, Severe and Prolonged Alopecia Areata A cohort study found comorbid asthma, atopic dermatitis and Hashimoto's thyroiditis are risk factors for early-onset, severe and prolonged alopecia areata.
- Skin image analysis for detection and quantitative assessment of dermatitis, vitiligo and alopecia areata lesions: a systematic literature review A systematic review examined computer vision techniques for detecting dermatitis, vitiligo and alopecia areata lesions, finding deep learning approaches promising for automated skin disease assessment.
- Dermal T cell immunity and key regulatory signaling pathways: Implications in immune-mediated alopecia and hair regeneration A review explains how T cells regulate hair follicle regeneration and how their disruption drives scarring and non-scarring immune-mediated alopecia.
- Recombinant Bacillus subtilis-derived alkaline protease: a novel agent for skin depigmentation and hair follicle neogenesis recombinant Bacillus subtilis-derived alkaline protease is proposed as an agent for skin depigmentation and hair follicle neogenesis.
- Decorin-mediated dermal papilla cell-derived exosomes regulate hair follicle growth and development through miR-129-2-3p/SMAD3/TGF-β axis In animal studies, decorin-enhanced dermal papilla cell exosomes promote hair follicle growth through the miR-129-2-3p/SMAD3/TGF-β regulatory axis.
- The role of reactive oxygen species in the pathogenesis of alopecia areata: a systematic review and meta-analysis. A meta-analysis found elevated oxidative stress markers and reduced antioxidant activity in alopecia areata patients, suggesting oxidative stress as a potential therapeutic target.
- Exosome‐derived long non‐coding RNA AC010789.1 modified by FTO and hnRNPA2B1 accelerates growth of hair follicle stem cells against androgen alopecia by activating S100A8/Wnt/β‐catenin signalling In lab work, exosome-derived lncRNA AC010789.1 modified by FTO and hnRNPA2B1 accelerated hair follicle stem cell growth via S100A8/Wnt/β-catenin signaling against androgenetic alopecia.
- Evaluation of Hair Growth Promoting Activity of Standardized Soybean Extract on Testosterone-Induced Alopecia A study of standardized soybean extract in testosterone-induced alopecia notes synthetic drug side effects but reports little on this popular natural alternative's characteristics.
- Alopecia Management Potential of Rosemary-Based Nanoemulgel Loaded with Metformin: Approach Combining Active Essential Oil and Repurposed Drug In rats, a rosemary-oil nanoemulgel loaded with metformin increased hair follicle numbers compared with controls.
- The Role of Mesenchymal Stem Cell-Derived Exosomes in Skin Regeneration, Tissue Repair, and the Regulation of Hair Follicle Growth A review explores the mechanisms by which mesenchymal stem cell exosomes may support skin regeneration and hair growth.
- Mechanistic study of Erianin in alopecia areata In C3H/HeJ alopecia areata mice, erianin suppressed disease and promoted hair regrowth by inhibiting effector T cells.
- Mechanism of PPAR&#x3B1; agonist in alopecia areata In mouse models, PPARα agonists showed protective effects in alopecia areata by inhibiting T effector cell function and exerting immunomodulatory effects.
- Development and evaluation of an integrated image-guided robotic system for hair transplant surgery An image-guided robotic system for hair transplant surgery achieved 89% follicle detection accuracy and 83% harvest success in silicone phantom testing.
- Novel delivery strategy: finasteride-loaded solid lipid nanoparticles for improved androgenetic alopecia therapy In mice, finasteride-loaded solid lipid nanoparticles increased skin retention and hair growth without visible skin reactions.
- Scalp Bacterial Profile and Antibiotics Susceptibility Pattern in Patients With Primary Cicatricial Alopecia A retrospective culture study found primary cicatricial alopecia scalps harbor more Staphylococcus aureus and gram-negative bacteria with elevated antibiotic resistance than controls.
- Asynchronous Teledermatology for Non-Scarring Alopecia: A Retrospective Study. In a retrospective series of 321 non-scarring alopecia telemedicine cases, a definitive remote diagnosis was made in 91.3%, with only 8.7% needing in-person follow-up.
- Intralesional Platelet-Rich Plasma Injection in Patients with Recalcitrant Alopecia Areata In 75 alopecia areata patients, intralesional PRP lowered SALT scores more than steroid injections at 3 and 6 months, though authors still recommend steroids first-line.
- Dimethylsiloxane polymers for the effective transdermal delivery of Minoxidil in hair loss treatment
- Herbal Remedies for Hair Loss: A Review of Efficacy and Safety
- A Clinical Evaluation of the Safety, Efficacy, and Tolerability of the Soulflower Rosemary Redensyl Hair Growth Serum, Tetragain™, in Healthy Female Subjects for the Treatment of Alopecia: Promoting Hair Growth and Reducing Gray Hair
- Caffeine as an Active Molecule in Cosmetic Products for Hair Loss: Its Mechanisms of Action in the Context of Hair Physiology and Pathology
- Compatibility of 17-a-estradiol, Caffeine, Clobetasol Propionate, Finasteride Melatonin, Metronidazole, Spironolactone, Tretinoin, and Triamcinolone in Trichosol, a Natural Vehicle for Hair Solutions.
- Mixture of Mastic Gum and Peppermint Extracts Promotes Hair Growth and Health in Vitro and in C57BL/6 Mice
- Topical Alternatives for Hair Loss: Beyond the Conventional
- Robust Metformin Nanosystem Promotes Hair Growth in Androgenetic Alopecia
- Perceptions and Experiences of Scalp Micropigmentation Among Dermatology Outpatients With Hair Loss: A Survey-Based Study
- Topiramate-induced hair loss in a patient using valproate and levetiracetam