August 202557
Adding low-level laser therapy to topical minoxidil was found to improve hair density and shaft thickness over minoxidil alone, with comparable side effects. Low-dose oral minoxidil showed no association with tachycardia in a large non-scarring alopecia cohort. Hair transplantation in women was reported to require screening for systemic causes, with many women favoring FUT over FUE. GLP-1 weight-loss drugs were linked to growing hair-loss reports, though causality is unconfirmed and most reports lacked dermatological confirmation. A dimethylglycine-caffeine shampoo was found to cut hairs lost on pull testing and raise density and anagen hairs in men. Compounded topical minoxidil gave Black women better adherence, fewer side effects and more improvement than prior OTC minoxidil.
- Comparative efficacy and safety of low-level laser therapy and topical Minoxidil combination vs. topical Minoxidil monotherapy in androgenetic alopecia management: a systematic review and meta-analysis of randomized controlled trials Meta-analysis of seven trials: adding low-level laser therapy to topical minoxidil improved hair density and shaft thickness more than minoxidil alone, with comparable side effects.
- Alopecia as an Emerging Adverse Effect Associated With Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists for Weight Loss: A Scoping Review A scoping review found growing reports of hair loss with GLP-1 weight-loss drugs, including over 1,000 FAERS cases, but causality is unconfirmed and most reports lacked dermatological confirmation.
- No association between low-dose oral minoxidil and tachycardia in a large retrospective cohort study of patients with non-scarring alopecia a large retrospective cohort study found no association between low-dose oral minoxidil and tachycardia in patients with non-scarring alopecia.
- Use of oral minoxidil for androgenetic alopecia in transgender and gender-diverse people. A retrospective study of 27 patients. a retrospective study of oral minoxidil for androgenetic alopecia in 27 transgender and gender-diverse patients.
- Hair Transplantation in Women. A review finds women seeking transplants present later with diffuse thinning, should be screened for systemic causes, and often favor FUT over FUE.
- Fibroblast bioelectric signaling drives hair growth A Cell study finds fibroblast membrane hyperpolarization via the KCNJ2 channel boosts Wnt signaling and rescues hair loss in aging and androgenetic alopecia mouse models.
- A Single Subcutaneous Dose of BMD-1141 Stimulates Hair Regrowth Comparable to Daily, High-Dose Ruxolitinib in a Mouse Model of Alopecia Areata. In mice, a single injection of the PTH-based drug BMD-1141 regrew hair comparably to daily high-dose ruxolitinib by stimulating the hair cycle.
- Strategies for Managing Suboptimal Response to JAK Inhibitors in Alopecia Areata a review of strategies for managing suboptimal response to JAK inhibitors in alopecia areata.
- Evaluating Current and Emergent JAK Inhibitors for Alopecia Areata: A Narrative Review A review summarizes three FDA-approved JAK inhibitors for alopecia areata, with 23–40% of trial patients reaching near-complete scalp coverage at 24–36 weeks.
- A novel cell-free regenerative therapy for hair loss: human fetal cartilage progenitor cell secretome A lab study shows human fetal cartilage progenitor cell secretome revived dermal papilla cells and regenerated hair follicles in mice and testosterone-treated rats.
- Safety of oral JAK inhibitors in treating alopecia areata: a systematic review and network meta-analysis A network meta-analysis of 12 RCTs (3,840 patients) found oral JAK inhibitors generally safe for alopecia areata; baricitinib raised acne, urinary infection and lipid risks, deuruxolitinib and ritlecitinib raised CPK, partly dose-dependent.
- Mechanisms and clinical progress of adipose-derived stem cells and their derivatives in the treatment of hair loss A review concludes adipose-derived stem cells and their derivatives show preclinical and early clinical potential to stimulate hair regeneration.
- Arginine Metabolic Disruption Impairs Hair Regeneration via ROS-Mediated Inactivation of mTOR Signaling in Androgenetic Alopecia. Lab work shows balding follicles are arginine-deficient, driving ROS that blocks mTOR signaling; restoring arginine rescued growth in mouse and humanized AGA models.
- Criteria for Commencing and Continuing Subsidised Janus Kinase Inhibitor Therapy in Australian Alopecia Areata Patients—Results From an Australian Expert Consensus Exercise An Australian expert consensus recommends JAK inhibitors for alopecia areata with over 50% scalp loss and defines failure as under 50% improvement after 12 months.
- Real-World Assessment of Disease Characteristics and Clinical Outcomes in Alopecia Areata in a Global Noninterventional Observational Cohort (ADAAGIO) In a 741-patient European real-world cohort, severe alopecia areata improved on average but only about 11% achieved near-complete regrowth sustained six months.
- A Novel Approach Against Male Pattern Hair Loss With Topical Dimethylglycine Sodium Salt (DMG‐Na) and Caffeine: Efficacy of a 24‐Week, Double‐Blind, Randomized, Placebo‐Controlled Trial In a 154-man placebo-controlled trial, a dimethylglycine plus caffeine shampoo cut hairs lost on pull testing and raised density and anagen hairs over six months with no adverse events.
- Enhanced Clinical Outcomes and Treatment Adherence in Patients Using Compounded Topical Minoxidil to Treat Androgenetic and Traction Alopecia. A retrospective review of 66 Black women found compounded minoxidil with steroid and retinoid gave better adherence, fewer side effects and more improvement than prior OTC minoxidil.
- Androgenetic Alopecia: An Update on Pathogenesis and Pharmacological Treatment A review concludes finasteride and minoxidil remain the only approved AGA drugs while agents targeting inflammation, fibrosis and energy metabolism are in development.
- Effect of topically applied simvastatin plus Luteolin on enhancing the development of hair in male mice. In mice, topical simvastatin and luteolin, alone or combined, increased hair growth, follicle diameter and growth-factor levels similarly to minoxidil.
- Comorbidities in primary cicatricial alopecia: a systematic review and meta-analysis A meta-analysis of 116 studies links scarring alopecias to lupus, hypothyroidism, dyslipidemia, skin cancers and other comorbidities varying by subtype.
- The Use of Imaging Techniques in the Diagnosis of Dermatoses of the Scalp A review surveys non-invasive imaging methods for diagnosing scalp diseases, listing advantages and limitations versus trichoscopy and biopsy.
- Correlation between changes of amino acid spectrum and alopecia in patients with obesity undergoing bariatric surgery: a prospective cohort study In a 67-patient bariatric surgery cohort, higher serum leucine three months post-surgery independently predicted worse postoperative hair loss.
- Multi-Omics Mendelian Randomization Reveals Causal Oxidative Stress Genes in Androgenetic Alopecia. Mendelian randomization analyses identified 33 oxidative-stress gene loci causally linked to AGA and suggested candidate drug targets.
- Nephronectin Mediates the Interaction between Hair Follicle Epithelial Progenitors and Dermal Stem Cells and Is Involved in Hair Cycle Progression the protein nephronectin links hair follicle epithelial progenitors with dermal stem cells and helps drive the hair cycle.
- Association between sleep patterns, circadian rhythms, and hair loss in young adults A cross-sectional study found evening chronotype was an independent risk factor for AGA, with delayed heart-rate rhythm and lower PER3 clock-gene expression in severe cases.
- Risk of autoimmune thyroid diseases in individuals with alopecia areata: A nationwide case‐control study a nationwide case-control study examines the risk of autoimmune thyroid diseases in people with alopecia areata.
- Increased serum leptin levels are potentially related to male frontal fibrosing alopecia increased serum leptin levels are potentially related to male frontal fibrosing alopecia.
- A Comprehensive Review of GWASs of Human Hair Traits A review of genome-wide studies on hair traits finds their genes overlap with hair disease genes, informing follicle biology.
- Recent Advances in the Role of Fibroblast Growth Factors in Hair Follicle Growth A review outlines how fibroblast growth factor signaling drives the hair cycle and could yield new alopecia treatments, though receptor mechanisms remain underexplored.
- Discordant Anisotrichosis: A Novel and Specific Trichoscopic Sign for Fibrosing Alopecia in a Pattern Distribution discordant anisotrichosis is proposed as a novel, specific trichoscopic sign of fibrosing alopecia in a pattern distribution.
- Clinicopathological Features and Pathogenesis of Thymoma Complicated with Alopecia Areata: A Multicenter, Matched Case Analysis In a matched analysis of 428 thymoma patients, the nine with alopecia areata showed more myasthenia gravis and CD4/CD8 inversion, suggesting distinct autoimmunity.
- Clinical Assessment of Alopecia Areata Severity and Validating the Patient Experience: A Vodcast A vodcast reviews tools for assessing alopecia areata severity, urging measures beyond scalp hair loss, including psychosocial impact.
- Comparison of the Efficacy of Topical Methotrexate 1% gel Versus Topical Betamethasone Dipropionate 0.05% Lotion in the Treatment of Localized Scalp Alopecia Areata in a Tertiary Care Institute of Central India: A Randomized Control Trial In a 70-patient trial, topical methotrexate 1% gel matched betamethasone lotion for patchy alopecia areata regrowth but caused significantly more itching and irritation.
- Vitamin D and its Analogs in Treatment of Mild to Moderate Alopecia Areata: Systematic Review and Meta-Analysis. A meta-analysis found topical or intralesional vitamin D3 gave about 54% success in mild-to-moderate alopecia areata with no serious adverse events, though it trailed corticosteroid injections.
- Discontinuation and restart of Janus kinase inhibitors due to pregnancy in alopecia areata: a case series In nine women with alopecia areata, stopping JAK inhibitors for pregnancy led to substantial hair loss, with most regrowing hair after restarting postpartum.
- Quality of life, psychosocial difficulties and bullying in paediatric patients with alopecia areata: a European cross-sectional study In a 417-person European study, adolescents with alopecia areata reported more bullying and emotional difficulties, especially girls and those with longer disease.
- Technological Advances in Anti-hair Loss and Hair Regrowth Cosmeceuticals: Mechanistic Breakthroughs and Industrial Prospects Driven by Multidisciplinary Collaborative Innovation A review of anti-hair-loss cosmeceuticals covers ingredients from minoxidil to peptides and gene therapy, noting efficacy, safety and regulatory hurdles.
- Dual-phase release finasteride-loaded microspheres for androgenetic alopecia treatment: rapid intervention and sustained control of dihydrotestosterone In AGA animal models, finasteride-loaded microspheres released drug rapidly then steadily over 28 days, cutting DHT early and promoting regrowth.
- Machine Learning-Driven Optimization of Therapeutic Substance Composition for High-Hardness, Fast-Dissolving Microneedles for Androgenetic Alopecia Treatment. In mice, machine-learning-designed fast-dissolving PRP microneedles regrew hair via Wnt/β-catenin activation, outperforming minoxidil.
- Therapeutic Potential of Carnosic Acid in Alopecia: A Mechanistic Perspective. A review describes carnosic acid from rosemary and sage as antioxidant, anti-inflammatory and anti-DHT in lab studies, but poor solubility limits clinical use.
- Nanovesicles from Adipose Derived Stem Cells Delay Hair Follicle Degeneration and Stimulate Regeneration: a Novel Therapeutic Strategy for Androgenetic Alopecia In mice, injected adipose stem-cell nanovesicles reversed follicle miniaturization and regrew hair comparably to minoxidil while reducing sebum.
- Association between alopecia areata and cardiovascular disease: a systematic review and meta-analysis A meta-analysis of 238,270 patients links alopecia areata to higher cardiovascular disease risk, strongest in alopecia totalis and universalis.
- Nitric Oxide Donor and Minoxidil Co‐Loaded Microneedles Improving Hair Loss Treatment In mice, microneedles co-delivering minoxidil and a nitric oxide donor via three minutes of skin pressure pushed follicles into growth phase and regenerated hair.
- Advances in the extracellular vesicles treatment of alopecia A review finds extracellular vesicles offer safety and storage advantages over drugs for alopecia, but dosing and large-scale production remain unresolved.
- The emotional impact of alopecia and role of psychological interventions in supporting patients with hair loss A clinic study found high emotional distress across hair disorders unrelated to severity, and formal psychological therapy improved patient wellbeing.
- Meta-Analysis of Gene Expression Reveals the Core Transcriptomic Profile of Lesional Scalp in Alopecia Areata A gene-expression meta-analysis of 132 scalp samples defines a core alopecia areata signature involving cytotoxic T cells, NK cells and JAK-STAT signaling.
- Human umbilical cord mesenchymal stem cell-derived exosomes enhance follicular regeneration in androgenetic alopecia via activation of Wnt/β-catenin pathway In mice, umbilical cord stem-cell exosomes carrying miR-21-5p and let-7b-5p activated Wnt/β-catenin signaling and promoted hair regrowth in an AGA model.
- Scalp acupoint catgut embedding combined with topical 5% minoxidil tincture to improve male androgenetic alopecia: protocol for a randomised controlled trial Protocol for a 70-man randomized trial of scalp acupoint catgut embedding plus 5% minoxidil versus sham embedding plus minoxidil.
- The Trilogy of Skin Regeneration via Metal-Organic Frameworks Nanomedicine: Precision Management of Refractory Wounds, Pathological Scarring, and Hair Follicle Reactivation A review maps how metal-organic framework nanomedicines might treat diabetic wounds, scarring and hair follicle regeneration, flagging unresolved safety and production issues.
- The Use of Light‐Based Therapies in the Treatment of Alopecia
- Hair greying associated with rosemary use: a cross-sectional study in Saudi Arabia
- Response to “Improvement of female pattern hair loss with bicalutamide: A time-dependent process”
- Improvement of female pattern hair loss with bicalutamide: A time-dependent process
- Impact of a Novel Dietary Supplement on Efficacy of Pharmacological Treatments for Androgenic Alopecia: A Real‐Life, Multicenter, Randomized, Assessor‐Blinded Trial on 225 Subjects
- Taming the Rash: A Dermatological Case Report on Effective Treatments for Refractory Folliculitis
- Evaluation of Effectiveness of Bio-Micro Injection in Treating Alopecia Universalis: A Non-Randomized Interventional Study
- Sulforaphane-Rich Broccoli Sprout Extract Promotes Hair Regrowth in an Androgenetic Alopecia Mouse Model via Enhanced Dihydrotestosterone Metabolism