October 202541
Low-dose oral minoxidil was reported to cause hypertrichosis in 24% and rare pericardial effusion, though long-term data are limited. AI imaging of oral minoxidil users showed significant density gains in non-scarring alopecia. A major androgenetic alopecia review covered proven therapies alongside emerging peptides and follicle bioengineering. A network meta-analysis confirmed dutasteride, minoxidil and finasteride efficacy while ranking topical melatonin and rosemary oil among OTC options. PRP added to transplantation improved density and follicle survival, though evidence remains limited. Amaranthus extract cream raised anagen density 54% versus 17.5% with placebo in a randomized trial. Botanical nutraceuticals increased hair shaft diameter in an uncontrolled study.
- Effects of GLP ‐1 Receptor Agonists on Hair Loss and Regrowth: A Systematic Review a systematic review of GLP-1 receptor agonist effects on hair loss and regrowth.
- Oral Minoxidil for Alopecia Treatment: Risks, Benefits, and Recommendations A review of low-dose oral minoxidil reports hypertrichosis in 24%, transient shedding 16–22% and rare pericardial effusion, with consensus dosing of 1.25 mg/day (women) and 2.5 mg/day (men); long-term data are limited.
- Androgenetic alopecia A major review of androgenetic alopecia covering causes, genetics, proven therapies (transplant, finasteride, minoxidil) and emerging options like peptides, mRNA liposomes and follicle bioengineering.
- Real-World Quantification of Treatment Response to Low-Dose Oral Minoxidil in Non-Scarring Alopecia In a retrospective study of 60 patients with androgenetic alopecia or telogen effluvium, AI imaging showed significant hair density gains over 4–8 months on low-dose oral minoxidil.
- Efficacy of Platelet-Rich Plasma as an Adjunct to Hair Transplantation: A Systematic Review A systematic review of 3 controlled studies (217 patients) found adding PRP to hair transplantation improved density, follicle survival and earlier growth, but protocols varied and evidence is limited.
- Relative Efficacy of Conventional Monotherapies and Select Nonconventional, Over‐the‐Counter Products for Male Androgenetic Alopecia: A Network Meta‐Analysis Study A network meta-analysis of 24 trials confirmed dutasteride, minoxidil and finasteride efficacy for male pattern hair loss and ranked OTC options like topical melatonin and rosemary oil against them.
- A 6-Month, Prospective, Multi-arm Study for the Efficacy of Standardized Nutraceuticals to Improve Hair Fiber Thickness and Strength In a 252-participant uncontrolled six-month study, botanical nutraceuticals significantly increased hair shaft diameter and reduced shedding across population-specific formulas.
- Comparative efficacy of Janus kinase inhibitors in severe alopecia areata: a network meta-analysis based on randomized controlled trials A network meta-analysis of 3,866 severe alopecia areata patients ranked deuruxolitinib 12 mg highest but imprecisely; baricitinib 4 mg showed significant, precise efficacy.
- A proprietary lipidosterolic extract of Serenoa repens promotes hair growth through mechanisms that extend beyond 5‐alpha reductase inhibition: Insights from human hair follicle organ culture In human hair follicle organ culture, a saw palmetto lipidosterolic extract inhibited 5-alpha reductase and prolonged anagen through additional mechanisms, suggesting potential beyond 5-AR inhibition.
- Uncontrolled Clinical Trial of Quality- and Quantity-cultured Peripheral Blood Mononuclear Cell Treatment for Androgenic Alopecia In a 5-man uncontrolled trial, scalp injections of cultured peripheral blood mononuclear cells significantly increased hair count, density, thickness and terminal density at 6 months with no adverse effects.
- Rebamipide Induces Hair Regeneration Through EP4-Driven Lipid Metabolism Remodeling In laboratory studies, the ulcer drug rebamipide activated hair follicle stem cells by binding the EP4 receptor and remodeling dermal fat cell metabolism.
- Defining a Therapeutic Window of Opportunity in Alopecia Areata: Predictors of Early Response to Baricitinib In 44 patients with alopecia areata, early baricitinib response was predicted by lower baseline SALT score, disease duration under 7 years, and elevated ESR.
- Hair Loss in Women A review of hair loss in women.
- Th,-e mechanistic insights into the application of retinoids and possible adjunct therapeutic treatment to androgenic alopecia A review suggests topical retinoids, especially combined with existing treatments, may extend the anagen phase and improve androgenetic alopecia outcomes.
- Androgenetic alopecia a primer on androgenetic alopecia.
- Natural Sweetener Stevioside‐Based Dissolving Microneedles Solubilize Minoxidil for the Treatment of Androgenic Alopecia In mice, a stevioside-based dissolving microneedle patch greatly increased minoxidil solubility and skin absorption, achieving 67.5% hair coverage by day 35.
- Evaluation of the efficacy and treatment-emergent adverse events of deuruxolitinib for moderate to severe alopecia areata: a dose-ranging meta-analysis of 1,372 randomized patients A meta-analysis of 1,372 randomized patients found deuruxolitinib significantly improved regrowth in moderate-to-severe alopecia areata; side effects (raised CPK, headache, acne at higher dose) were generally manageable, but long-term safety monitoring is needed.
- Comparative Efficacy of Topical Chitosan and Minoxidil in Hair Loss: A Controlled Study With Microneedling In a 30-patient trial, microneedling plus 2% chitosan raised hair density 30.5% versus 22.3% with 5% minoxidil, a non-significant difference; both beat no treatment.
- Amaranthus Extract Promotes Healthy Follicles and Anagen Hair Density-A Randomized Placebo-Controlled, Double-Blinded Study. In a 50-man randomized trial, amaranthus extract cream raised terminal hair density 28% and anagen density 54% over 90 days versus 15% and 17.5% with placebo, with no adverse effects.
- Caffeine Supplementation and Hair: A Systematic Review A systematic review of nine studies found topical caffeine consistently promoted hair growth or reduced shedding with minimal side effects, but better trials are needed.
- The Psychiatric Burden in Alopecia Areata: A Propensity-Matched Cohort Study In a matched cohort of 57,389 adults, alopecia areata carried a 4.5-fold higher risk of new psychiatric disorders, especially in women and post-COVID.
- T <sub>H</sub> 1 effector CD4 T cells rely on IFN-γ production to induce alopecia areata In mice, Th1-type CD4 T cells transfer alopecia areata only when they produce IFN-gamma and host CD8 T cells are present.
- Predictive Factors of Response and Real‐World Experience of Baricitinib on Alopecia Areata: A Single Tertiary Center Study on a 72 Patients' Cohort a 72-patient single-center study examines predictive factors and real-world experience of baricitinib in alopecia areata.
- Management of Folliculitis Decalvans: A Systematic Review A systematic review of 728 folliculitis decalvans patients found combination therapy with systemic antibiotics plus other agents gave the longest effect, with growing roles for biologics and laser therapy.
- Is Spontaneous Regrowth in Alopecia Areata Possible: A Systematic Review and Meta-analysis of Placebo-controlled Studies a systematic review and meta-analysis of placebo-controlled studies examines whether spontaneous regrowth occurs in alopecia areata.
- Phytochemicals for Hair Health Targeting Growth Signaling Molecules in Hair Follicular Stem Cells: A New Strategy for Hair Growth A review compiles plant-derived compounds that activate Wnt, Shh and JAK-STAT hair-growth pathways as potential natural hair-loss treatments.
- Synergizing biomaterials and cellular molecular pathways: a new frontier in hair follicle generation A review of follicle biofabrication says organoids, micropatterning and 3D printing are promising but functional cycling follicles remain elusive.
- Follicles Twisted During Follicular Unit Excision Could Survive in the Skin of Nude Mice In nude mice, twisted-bulb FUE grafts survived as well as intact follicles (75% vs 73%), while fractured-shaft grafts survived poorly (33%).
- Randomized Controlled Trial of the Topical Jak Inhibitor Delgocitinib Cream in Patients with Frontal Fibrosing Alopecia In a 30-woman phase 2a trial, topical delgocitinib cream improved the transcriptomic profile of frontal fibrosing alopecia lesions and was well tolerated.
- Rationale and Design of a Novel, Phase 3, External and Synthetic Placebo-Controlled Clinical Trial of Ritlecitinib 50 mg and 100 mg for Alopecia Areata A phase 3 trial will test ritlecitinib 100 mg versus 50 mg in alopecia areata using external and synthetic placebo controls instead of a randomized placebo arm.
- A systematic review of procedural modalities in the treatment of lichen planopilaris, frontal fibrosing alopecia, and discoid lupus erythematosus A systematic review of 38 studies found platelet products and intralesional steroids best for scarring alopecia symptom control, with hair transplant grafts progressively lost by 3–5 years.
- An Interventional, Comparative, Prospective Study to Determine Optimum Concentration of Intralesional Triamcinolone Acetonide in Treatment of Alopecia Areata In 35 alopecia areata patients, intralesional triamcinolone 2.5 mg/mL produced >75% regrowth in 62.8% of patches versus none with 1.25 mg/mL, supporting 2.5 mg/mL as minimal effective concentration.
- [[Translated article]]RF- Mesotherapy with Bicalutamide: A Novel Alternative for Androgenetic Alopecia radiofrequency mesotherapy with bicalutamide as a novel alternative for androgenetic alopecia.
- Improvement in Patient‐Reported Emotional Symptoms and Activity Limitations due to Hair Loss in Patients With Alopecia Areata Treated With Ritlecitinib: Additional Analyses From ALLEGRO ‐2b/3 In ALLEGRO-2b/3, 50-mg ritlecitinib improved emotional symptoms and activity limitations from alopecia areata versus subtherapeutic 10-mg dosing by week 48.
- A multicentre cohort study of the clinicopathological features and treatment outcomes of fibrosing alopecia in a pattern distribution In a 110-patient multicentre cohort of fibrosing alopecia in a pattern distribution, combination anti-inflammatory and minoxidil treatment stabilized or improved hair density in most treated patients.
- Hair growth promoting effects of andrographolide from Andrographis paniculata (Burm.f.) Wall. ex Nees : In vitro, in vivo, and molecular docking studies In cultured follicles and mice, andrographolide from Andrographis paniculata promoted hair shaft elongation and growth via Wnt/β-catenin activation, comparable to minoxidil at tested doses.
- Immune therapies for alopecia areata: evidence and new perspectives A review of alopecia areata immunology and treatments concludes biomarker-driven patient stratification is needed to optimize drug selection and reduce trial-and-error therapy.
- Integrated Meta-Analysis of Scalp Transcriptomics and Serum Proteomics Defines Alopecia Areata Subtypes and Core Disease Pathways A meta-analysis of scalp transcriptomics and serum proteomics defined alopecia areata subtype pathways, identifying immune activation, ferroptosis-related and structural gene changes as potential disease indicators.
- LncRNA RP11-818O24.3 regulates proliferation and differentiation of hair follicle stem cells by targeting FGF2/PI3K/AKT pathway In cultured hair follicle stem cells, lncRNA RP11-818O24.3 promoted proliferation and differentiation while inhibiting apoptosis via the FGF2/PI3K/AKT pathway.
- Advanced medical treatments for hair loss A review of advanced hair loss treatments including stem cells, hair follicle cells, growth factors, extracellular vesicles, gene therapy and tissue engineering.
- Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss