June 202553
A network meta-analysis of 33 studies found dutasteride 0.5 mg daily ranked most effective for male pattern hair loss. Growth factor concentrate versus PRP was reported to give faster hair count gains, while PRP gave more sustained improvement. In a placebo-controlled trial, rosemary oil blends for pattern hair loss improved growth rate, thickness, and density compared with coconut oil. A retrospective database study found dutasteride versus finasteride carried similar risk of sexual dysfunction. In breast cancer patients, scalp cooling during chemotherapy retained visible hair in 53%, with follicle measurements predicting success. An uncontrolled study found botanical shampoo and tonic reduced hair loss area in men with pattern hair loss. A review of female hair loss explored saw palmetto and pumpkin seed oil as non-pharmaceutical options.
- Comparative Efficacy of Minoxidil and 5‐Alpha Reductase Inhibitors Monotherapy for Male Pattern Hair Loss: Network Meta‐Analysis Study of Current Empirical Evidence A network meta-analysis of 33 studies ranked dutasteride 0.5 mg daily most effective; topical minoxidil 5% and finasteride 1 mg led approved options.
- Clinical and Trichoscopic Analysis of PRP Versus GFC Used for Male and Female Pattern Hair Loss In 42 pattern hair loss patients, GFC gave faster hair count gains while PRP gave more sustained improvement at six months.
- Rosmagain™ as a Natural Therapeutic for Hair Regrowth and Scalp Health: A Double-Blind, Randomized, Three-Armed, Placebo-Controlled Clinical Trial In a 90-patient RCT, rosemary-lavender and rosemary-castor oils significantly improved hair growth rate, thickness, and density by up to 68% compared to coconut oil.
- Similar Risk of Sexual Dysfunction in Androgenetic Alopecia Patients Treated With Dutasteride vs. Finasteride: A Retrospective Cohort Database Study a retrospective database study found similar risk of sexual dysfunction in AGA patients treated with dutasteride versus finasteride.
- Alopecia in Children with Cancer: A Review from Pathophysiology to Management A review finds that no standard interventions exist for pediatric chemotherapy-induced alopecia, though scalp cooling is under investigation and minoxidil may improve regrowth.
- Controlled Release of Minoxidil through Hydrogel Cross-Linking to Treat Androgenetic Alopecia Injectable hydrogel and microneedle patches released minoxidil over six weeks and induced hair growth in mice.
- Assessment of long-term alopecia after adjuvant taxane therapy for early breast cancer: a cross-sectional survey In a survey of 88 breast cancer survivors, adjuvant docetaxel caused significantly more chronic alopecia and dissatisfaction than paclitaxel.
- Long‐Term Real‐World Outcomes of Baricitinib in Severe Alopecia Areata: A 104‐Week Retrospective Analysis From a Single Institute In 51 severe AA patients, 56% reached near-complete regrowth on baricitinib by 104 weeks; female sex and shorter disease predicted response.
- Pathophysiology, conventional treatments, and evidence-based herbal remedies of hair loss with a systematic review of controlled clinical trials A systematic review of 16 RCTs found rosemary, saw palmetto, ginseng and other herbal remedies show promising but low-certainty hair growth effects.
- Targeting olfactory receptor OR2AT4: An innovative aptamer-based treatment for hair growth promotion A lab study identified a DNA aptamer targeting olfactory receptor OR2AT4 that prolonged the anagen phase and enhanced hair shaft elongation in human hair follicles.
- Therapeutic potential of isoproterenol in androgenetic alopecia: activation of hair follicle stem cells via the PI3K/AKT/β-Catenin signaling pathway Isoproterenol reactivated dormant follicle stem cells and promoted growth in cultured AGA follicles via the PI3K/AKT/beta-catenin pathway.
- Pathophysiological mechanisms of hair follicle regeneration and potential therapeutic strategies A review maps Wnt, Shh, BMP and Notch signaling in follicle regeneration and preclinical drugs targeting them for AGA.
- Hair growth stimulated by allogenic adipose-derived stem cells supplemented with ATP in a mouse model of dihydrotestosterone-induced androgenetic alopecia In DHT-induced AGA mice, adipose stem cell injections supplemented with ATP improved hair regrowth, with dose effects differing by sex.
- Botanical Extract–Infused Shampoo and Hair Tonic for Hair Loss in Androgenetic Alopecia: A TREND‐Compliant, Prospective Single‐Arm Preexperimental Study In a 35-man uncontrolled study, a botanical shampoo and tonic reduced hair loss area and improved scalp symptoms over six months.
- Hair Loss in Teenagers: A Review for Primary Care Pediatricians A review for primary care pediatricians outlines the common causes of adolescent hair loss, diagnostic approaches, and management strategies.
- Optimizing Scalp Cooling: (Ultra)Structural Follicular Characteristic and Restorative Advances In a study of 81 breast cancer patients, 53% retained visible hair during scalp cooling, with bulb diameter, shaft diameter, and anagen rate strongly predicting success.
- Addressing the Root Causes of Female Hair Loss and Non-Pharmaceutical Interventions. A review notes that female hair loss is often driven by hormonal imbalances, inflammation, and nutrient deficiencies, and explores natural interventions like saw palmetto and pumpkin seed oil.
- Examining the Relationship Between Alopecia Areata and Mental Health: An Investigation of the Global Burden of Disease Study 2021 An analysis of global data found significant positive correlations between alopecia areata and anxiety and depression, particularly in younger females.
- Nanotechnology-based topical treatments for androgenic alopecia A review of nanotechnology-based topical treatments for androgenetic alopecia.
- Alopecia in Female Athletes Using Androgenic and Anabolic Steroids: Pathophysiology and Management A review covers how anabolic steroid use accelerates female pattern hair loss in athletes and outlines management strategies.
- Case Report: Omalizumab-associated hair loss: a case of eyebrow alopecia areata, literature review and FAERS database analysis A case report and FAERS database analysis suggest omalizumab may induce alopecia, particularly in females aged 18-60, though a direct causal link is challenging to establish.
- Cross‐Sectional Analysis of Subclinical Findings Using High‐Frequency Ultrasound in Frontal Fibrosing Alopecia In 15 women with frontal fibrosing alopecia, high-frequency ultrasound quantified dermal thinning and follicle loss and detected subclinical inflammation in 27%.
- Lnc056 Enhances Hair Follicle Stem Cells Proliferation by Binding Transcription Factor HNRNPUL1 to Up-Regulate TRIP6 Expression. In goat follicle stem cells, lncRNA lnc056 promoted cell proliferation via the HNRNPUL1/TRIP6 axis.
- Lessons from TNF-α Inhibitor–Induced Alopecia Areata: Does TNF-α Operate as a Hair Follicle Immune Privilege Guardian under Inflammatory Conditions? A commentary proposes TNF-alpha may guard hair follicle immune privilege, explaining why TNF inhibitors sometimes trigger alopecia areata.
- Alopecia areata following semaglutide treatment for weight loss: A case report A case report describes alopecia areata developing in a patient taking semaglutide for weight loss.
- Single-cell analysis of temporal immune cell dynamics in alopecia areata reveals a causal role for clonally expanded CD8+ T cells in disease In a mouse model of alopecia areata, single expanded CD8+ T-cell clones were shown sufficient to trigger disease.
- Characterizing Tofacitinib Response in Pediatric Alopecia Areata: A Retrospective Review A retrospective review characterizes how children with alopecia areata respond to tofacitinib.
- Shen-Ying-Yang-Zhen formula promotes angiogenesis around hair follicles, alleviates oxidative stress, and inhibits hair follicle apoptosis through the VEGF/Akt/Caspase-9 signaling axis In a mouse model, Shen-Ying-Yang-Zhen formula increased hair follicle density and skin thickness by 2.8-fold by promoting angiogenesis and reducing oxidative stress.
- Wnt10b Regulation of Hair Follicle Development, Regeneration, and Skin Diseases A review explores the role of Wnt10b signaling in hair follicle development, regeneration, and its association with skin diseases.
- Use of low-dose oral minoxidil for hair growth in transgender and gender non-binary adult patients: a retrospective cohort study a retrospective cohort examined low-dose oral minoxidil for hair growth in transgender and gender non-binary adults.
- Retinoic-Acid-Related Orphan Receptor Alpha Is Involved in the Regulation of the Cytoskeleton of Hair Follicle Stem Cells In cultured follicle stem cells, RORalpha activation altered cytoskeleton genes and inhibited cell migration and adhesion.
- Predominance of CD27-PD-1- Effector Memory T Cells Re-Expressing CD45RA Characterizes Treatment-Resistant Severe Alopecia Areata A specific effector memory T-cell subtype characterizes treatment-resistant severe alopecia areata.
- Impact of nutraceutical supplements on hair growth in non-scarring alopecia: a systematic review and meta-analysis A systematic review and meta-analysis of nutraceutical supplements for hair growth in non-scarring alopecia.
- Localized corticosteroid delivery in alopecia areata using microneedle patch technology In 14 alopecia areata patients, a corticosteroid microneedle patch produced regrowth comparable to injections with low pain scores.
- Tumor necrosis factor α inhibitor-induced alopecia in pediatric patients: a cohort of 20 patients and review of the literature In 20 children, TNF-alpha inhibitor-induced alopecia reversed within six months of stopping the drug; continued use prevented regrowth.
- Oral minoxidil treatment of alopecia areata A report on oral minoxidil as a treatment for alopecia areata.
- VDAC2 Mediates the Apoptosis of Cashmere Goat Hair Follicle Stem Cells Through the P53 Signaling Pathway In cashmere goats, VDAC2 mediates apoptosis of hair follicle stem cells through the P53 signaling pathway, suggesting a regulatory role in hair growth.
- From Spheroid to Sprouting: Microenvironmental Modulation Boosts Hair Follicle Organoid Morphogenesis in 3D Culture In 3D culture, RSPO1 boosted hair follicle organoid sprouting by activating Wnt and related signaling pathways.
- Spiny mice (Acomys) regenerate wounded whisker pad skin with whisker follicles, muscles, and targeted innervation Spiny mice regenerated wounded whisker-pad skin including follicles, muscle, and nerves, though only about 20% of whiskers regrew.
- The Multi-Faceted Role of Gut Microbiota in Alopecia Areata A review analyzes the role of gut microbiota in alopecia areata, suggesting dysbiosis may contribute to disease onset and progression.
- Correlation between increased total serum IgE levels and clinical features in alopecia areata patients In 436 alopecia areata patients, serum IgE was elevated in 31%, especially males, children, and severe cases.
- Bad Hair Days: A Clinical and Trichoscopic Evaluation of Scalp Lesions In a study of 200 patients, trichoscopy was found to be a valuable tool for diagnosing scalp lesions, distinguishing between scarring and non-scarring alopecia.
- Perspectives of Chinese Adult Patients with Alopecia Areata on Janus Kinase Inhibitors Therapy: A Qualitative Analysis Based on Social Media Platforms Analysis of 300 Chinese social media posts found AA patients focused on JAK inhibitor efficacy, relapse after stopping, and side effects.
- Clinical Efficacy of Composite Autologous Chylated Fat and Concentrated Growth Factors for Treating Postinjection Alopecia After Facial Fillers: A Single‐Center Retrospective Study In a 9-patient case series, autologous chylated fat and concentrated growth factors significantly improved hair density and diameter in post-filler alopecia.
- Efficacy and Safety of Autologous Follicular Unit Excision in Pediatric Secondary Cicatricial Alopecia: A Retrospective Case Series In a retrospective case series of 11 pediatric patients, FUE hair transplantation was a safe and effective method for treating stable cicatricial alopecia, with a 72.7% satisfaction rate.
- The Current State of Patient Adherence to Lab Monitoring Guidelines for Janus Kinase Inhibitors in Patients with Alopecia Areata. A chart review of 57 alopecia areata patients on JAK inhibitors found they were not adhering to recommended three-monthly lab monitoring.
- Role of UVA-driven cellular senescence via mTOR activation in dihydrotestosterone-induced hair loss in androgenetic alopecia mouse model
- Prostaglandin F2α stimulates the growth of human intermediate hair follicles in ex vivo organ culture with potential clinical relevance
- Restoration of Hair Luster via Novel Biomarker COL7A1 by Minoxidil, Caffeine, and Biotin
- Development of Ethosomes for the Topical Treatment of Androgenic Alopecia: Ethanol Effect on Dutasteride Targeting to the Hair Follicles
- Demodex folliculorum
- Enhancing hair regrowth using rapamycin-primed mesenchymal stem cell-derived exosomes
- Remarkable findings in male pattern baldness: sugar molecule 2dDR offers hope for hair regrowth