November 202550
PRP against topical minoxidil was found to match minoxidil on hair density and regrowth, with higher patient satisfaction, in a meta-analysis of randomized trials. A saw palmetto fatty acid extract was reported to improve hair counts versus placebo in adults with self-perceived thinning hair. Deuruxolitinib in severe alopecia areata achieved scalp regrowth in roughly a third of patients versus almost none on placebo. A pharmacovigilance analysis of drug-induced alopecia flagged 64 drugs, mostly oncology agents, and found many lack alopecia on their labels. Plant-derived nanoparticles in mice suppressed androgen receptor signaling and outperformed minoxidil. Rhamnose in mice and cultured follicles promoted hair growth by boosting glycolysis. Tamoxifen after scalp cooling was linked to sharply higher odds of persistent chemotherapy-induced alopecia.
- Comparative Efficacy and Safety of Platelet Rich Plasma (PRP) versus Topical Minoxidil for Androgenetic Alopecia: A Systematic Review and Meta-analysis A meta-analysis of nine RCTs found PRP matched minoxidil on hair density and regrowth for androgenetic alopecia, with higher patient satisfaction.
- The Safety and Efficacy of a Proprietary Bioactive Fatty Acids Extract From Saw Palmetto ( <i>Serenoa repens</i> ) for Promoting Hair Growth and Reducing Hair Loss in Adults With Self‐Perceived Thinning Hair: 90‐Day Results In a randomized trial, a proprietary saw palmetto fatty acid extract significantly improved hair counts versus placebo over 90 days in adults with self-perceived thinning hair.
- Efficacy and safety of deuruxolitinib, an oral selective Janus kinase 1/2 inhibitor, in adults with alopecia areata: Results from the THRIVE-AA2 Phase 3, randomized, double-blind, controlled trial In a 517-patient phase 3 trial, deuruxolitinib achieved SALT20 in 33–38% of severe alopecia areata patients versus 0.8% on placebo.
- Real-world pharmacovigilance insights into drug-induced risk of alopecia Analysis of 181,838 FDA adverse-event reports flagged 64 drugs with alopecia signals—oncology drugs strongest—and found 23% of high-signal drugs lack alopecia on their labels.
- Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity In mice, acute stress drove sympathetic nerves to kill hair follicle progenitor cells, triggering autoreactive T cells that can later attack follicles.
- Effectiveness and safety of Baricitinib in alopecia areata: a prospective cohort study In a 48-patient real-world cohort, baricitinib was effective for severe alopecia areata, with lower baseline SALT, shorter disease duration and higher ESR predicting response.
- Multi-omics identifies L-rhamnose as a metabolic regulator that enhances glycolysis to promote hair follicle growth In mice and cultured human follicles, the sugar rhamnose promoted hair growth by boosting glycolysis via direct binding to hexokinase 2.
- Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK / STAT1 signaling pathway In mice, cyclophosphamide suppressed follicle Shh via JAK/STAT1 signaling, and JAK inhibitors rescued the chemotherapy-induced hair loss.
- Morphometric prediction of mesenchymal stromal cell-like immunosuppressive capacity of human hair follicle dermal sheath cup cells: an implication for regenerative medicine in hair loss diseases Human hair follicle dermal sheath cup cells suppressed T-cell proliferation in vitro, and a shape-based assay predicted this immunosuppressive capacity.
- Cross-kingdom delivery and putative gene modulation of androgen pathways by plant-derived exosome-like nanoparticles from polygoni multiflori radix promotes hair growth via miRNA cargo Plant-derived nanoparticles from Polygonum multiflorum suppressed androgen receptor signaling and outperformed minoxidil in testosterone-treated mice.
- Association of Janus kinase inhibitors with reduced depression in alopecia areata In a matched database cohort of 1,838 pairs, JAK inhibitor treatment for alopecia areata was associated with 58% lower depression risk.
- Longitudinal clinical course, treatment outcomes, and relapse patterns in alopecia areata: a prospective cohort study In a 400-patient prospective cohort, 62.5% of alopecia areata patients achieved SALT50 by week 24 and 31.8% relapsed by week 52.
- British Association of Dermatologists living guideline for managing people with alopecia areata 2025 The British Association of Dermatologists' 2025 guideline issued 56 recommendations for managing alopecia areata.
- Clinical and genetic predictors of persistent chemotherapy-induced alopecia despite scalp cooling in breast cancer Tamoxifen monotherapy raised odds of persistent chemotherapy-induced alopecia despite scalp cooling nearly 12-fold in a post hoc trial analysis.
- Real-World Effectiveness of JAK Inhibitors for Alopecia Totalis and Alopecia Universalis: A Single-Center Experience In 45 real-world alopecia totalis/universalis patients, 48–50% on ritlecitinib or tofacitinib reached SALT≤20 by week 24, baricitinib 16.7%.
- Updated Integrated Safety Analysis of Ritlecitinib Up to ~5 Years in Patients With Alopecia Areata From the ALLEGRO Clinical Trial Program Pooled trial data showed ritlecitinib was generally well tolerated up to about 5 years in alopecia areata; serious AEs 6.8%, with low rates of herpes zoster, malignancies and cardiovascular events.
- Alopecia areata A primer reviews alopecia areata, noting FDA approvals of JAK inhibitors in 2022–2023 transformed treatment for severe disease.
- Battling a receding tide: Treatment for androgenic alopecia A review outlines assessment and treatment options for a man with pattern hair loss presenting to general practice.
- The hidden burden of visibility: Social appearance anxiety in patients with alopecia areata – A comparative cross-sectional study A cross-sectional study found alopecia areata patients had triple the social appearance anxiety of controls, driven by visibility of lesions.
- Pyroptosis in Alopecia Areata: Synthesizing Emerging Hypotheses and Charting a Path to New Therapies A review links inflammasome-driven pyroptosis to alopecia areata and highlights potential targeted therapies, mostly preclinical.
- Increased Prevalence of Insulin Resistance and Metabolic Syndrome in Men With Early‐Onset Androgenetic Alopecia: A Case–Control Study A case-control study found men with early-onset androgenetic alopecia had higher rates of insulin resistance (18% vs 4%) and metabolic syndrome than controls.
- Development of the AAcQLI : A New Instrument for Assessing Quality of Life in Children With Alopecia Areata A study developed the AAcQLI, a 20-child-validated tool for measuring quality of life in children with alopecia areata.
- Upadacitinib for the treatment of refractory alopecia areata in pediatric patients: A retrospective study A retrospective study examined upadacitinib for refractory alopecia areata in pediatric patients.
- Evaluation of Anthropometric Measurements, Arterial Stiffness and ECG Parameters in Alopecia Areata Patients In a case-control study, alopecia areata patients had lower heart rates but no differences in arterial stiffness versus controls.
- Ophthalmologic Comorbidities in Alopecia Areata A review summarizes links between alopecia areata and ocular abnormalities and practical considerations for dermatology practice.
- Justicia procumbens promotes hair growth and ameliorates age-related deterioration of hair health In mice, Justicia procumbens extract promoted hair regrowth via beta-catenin signaling and reduced age-related follicle and vascular damage; human efficacy unproven.
- Association between SQSTM1 dysregulation and risk in alopecia areata: a Mendelian randomization study A Mendelian randomization study implicated SQSTM1 dysregulation in alopecia areata risk, confirmed in affected hair follicles.
- The Evolving Global Burden of Alopecia Areata in Young Adults: High-Income Nations Bear the Greatest Impact Global alopecia areata burden in young adults declined from 1990 to 2021 but remains concentrated in high-income nations.
- Mapping cell dynamics in human ex vivo hair follicles suggests pulling mechanism of hair growth 3D live imaging of cultured human hair follicles suggests outer root sheath cells generate a pulling force that helps extrude the hair fiber.
- Influence of Surface Functional Groups on the Hair Growth-Promoting Activities of Nanochitins: An In Vitro Analysis Four nanochitin types promoted hair growth in mice and boosted VEGF/FGF-7 secretion in cell culture, with effects varying by surface chemistry.
- Pathogenic variants affecting peptidyl arginine deiminase 3 and its major substrates underlie central centrifugal cicatricial alopecia Exome sequencing of 75 CCCA patients found pathogenic variants in PADI3 and its substrate genes S100A3 and TCHH, disrupting hair shaft integrity.
- Immortalized human hair follicle-derived mesenchymal-like stromal cells for the long-term production of scalable Immunomodulatory and regenerative secretome Immortalized human hair follicle stromal cells produced scalable immunomodulatory and regenerative secretome in the lab.
- When JAK inhibitors are off the table: durable remission of severe alopecia areata with dexamethasone oral mini-pulse and a focused review A case report plus review found dexamethasone oral mini-pulse achieved durable remission in severe alopecia areata when JAK inhibitors are unsuitable.
- Lacticaseibacillus Paracasei CCFM1350 Demonstrates Potentials in Hair Growth and Treating Alopecia in Mice The probiotic Lacticaseibacillus paracasei CCFM1350 increased hair growth 3.5-fold via Wnt/β-catenin signaling in mice.
- Psychometric validation of the Spanish alopecia areata–life impact questionnaire A study validated the Spanish AA-life impact questionnaire with good reliability and severity cut-off scores.
- Associations Between Iron Metabolism and Obstructive Sleep Apnea Severity in Female and Male Individuals With Self‐Reported Androgenetic Alopecia: A Propensity‐Score Matching Analysis From the EPISONO Database A matched analysis found serum iron and ferritin correlated with obstructive sleep apnea severity in people with self-reported androgenetic alopecia.
- Immune Cell-Targeting Biologics for Alopecia Areata: A New Paradigm in Precision Medicine A review of immune cell-targeting biologics for alopecia areata found mostly anecdotal responses, with controlled trials largely negative.
- Cold Atmospheric Plasma‐Activated In Situ Hydrogel Induces Hair Regeneration Via Immune Microenvironment Remodeling A plasma-activated IL-2 hydrogel expanded regulatory T cells and promoted hair regeneration in depilated mice.
- Alopecia areata: from immunopathogenesis to emerging therapeutic approaches A review covers immune mechanisms and emerging therapies for alopecia areata, including JAK inhibitors and novel antibody approaches.
- FGF22 Secreted by Hair Papilla Cells Regulates Hair Follicle Stem Cell Proliferation and Differentiation In a cell co-culture system, FGF22 from dermal papilla cells boosted hair follicle stem cell proliferation via Wnt, Shh, and Notch signaling.
- A Systematic Review of Follicular Unit Graft Survival Rates After Hair Transplantation in Primary Cicatricial Alopecia A systematic review of follicular unit graft survival rates after hair transplantation in primary cicatricial alopecia.
- Stingless bee propolis promotes hair follicle regeneration and melanocyte function in chemotherapy-induced alopecia mouse model In mice with chemotherapy-induced alopecia, topical stingless bee propolis increased folliculogenesis and melanogenesis versus controls.
- Sequential immunotherapy for alopecia areata: phase-driven immune rebalancing A review proposes sequential immunotherapy—intensive immunosuppression then maintenance—to address alopecia areata recurrence and resistant cases.
- Hair Repigmentation Outcomes in Patients With Graying Hair Treated With Exosome Therapy: A Cross‐Sectional Observational Study In a 10-patient observational study, rose stem cell exosome therapy produced hair repigmentation lasting about 4.7 months on average.
- Causal Relationship Between Sleep Characteristics and Alopecia Areata and Other Non-Scarring Alopecia: A Two-Sample Bidirectional Mendelian Randomization Analysis A Mendelian randomization study found insomnia may raise alopecia areata risk, but associations did not survive multiple testing correction.
- Cell‐free transcriptomic profiles and mechanism insights in female androgenetic alopecia A study profiled cell-free transcriptomes to probe mechanisms in female androgenetic alopecia.
- Rejuvenating senescent hair follicles: a novel conjugated linoleic acid based nanovesicle approach to treat androgenic alopecia
- Botanical drug preparations for alleviating hair loss in menopausal women: a global ethnopharmacological mini-review
- Preliminary Study on Platelet-Rich Plasma Enhancing Autophagy Level and Promoting Hair Growth in Androgenetic Alopecia Model Mice
- Integrated transcriptomic and proteomic analysis reveals molecular mechanisms of melatonin-regulated hair follicle growth in cashmere goats and comparative insights across goat breeds