April 202547
In a randomized trial, creatine supplementation in young men did not raise DHT or worsen hair density, arguing against the hair-loss claim, though follow-up was short. Adding topical finasteride to minoxidil showed no benefit over minoxidil alone. Microneedle-delivered PRP matched intradermal injection for efficacy while causing less pain. Microneedling with topical cetirizine improved hair density versus saline microneedling. QR678 Neo peptide solution during FUE improved regrowth and density over conventional transplant. Rhus semialata gall extract improved hair density versus placebo in a trial. Microneedling users adhered better than medication users. For alopecia areata, azathioprine in severe cases gave about 93% regrowth, though uncontrolled and retrospective, while CO2 laser plus bimatoprost doubled response rates versus laser alone.
- Does creatine cause hair loss? A 12-week randomized controlled trial In a 12-week randomized trial of 45 young men, creatine did not raise DHT or worsen hair density or follicle measures, providing evidence against the hair-loss claim, though follow-up was short.
- Comparison of Topical Finasteride and Oral Finasteride in the Treatment of Androgenic Alopecia. A Systemic Review and Meta-Analysis a systematic review and meta-analysis comparing topical and oral finasteride for androgenetic alopecia.
- Randomized controlled trial on the efficacy and safety of the combination therapy of topical 0.1% finasteride − 5% Minoxidil in male androgenetic alopecia In a 40-man trial, adding topical finasteride 0.1% to minoxidil 5% did not improve results over minoxidil alone at 12 weeks, with similar side effects.
- Platelet-rich plasma for androgenetic alopecia: intradermal injection or microneedle delivery? In a 20-patient split-scalp trial, microneedle-delivered PRP matched intradermal injection for AGA efficacy while causing significantly less pain.
- The efficacy of topical cetirizine using microneedling in androgenetic alopecia male patients In an 80-man trial, microneedling with 1% topical cetirizine improved hair density versus saline microneedling over 8 weeks, without notable side effects.
- Efficacy and Safety of Long‐Term Azathioprine Therapy for Severe Alopecia Areata: A 10‐Year Cohort Study In a 63-patient 10-year cohort, azathioprine gave about 93% mean hair regrowth in severe alopecia areata and was judged safe, though it is an uncontrolled retrospective series.
- Novel Electrotrichogenic Device Promotes Hair Growth in Men With Androgenetic Alopecia: A Pilot Study In a 21-man uncontrolled pilot, daily use of the niostem electrical stimulation device increased hair density 19.3% over 6 months with no reported adverse events.
- Comprehensive Review on Hair Loss and Restorative Techniques: Advances in Diagnostic, Artistry, and Surgical Innovation A review surveys hair loss diagnostics, low-dose oral minoxidil, JAK inhibitors, PRP, lasers, and robotic transplant techniques.
- Enhancing hair regrowth in Alopecia areata: the power duo of CO2 fractional laser and Bimatoprost In a 60-patient alopecia areata trial, CO2 fractional laser plus bimatoprost 0.03% doubled response rates versus laser alone (80% vs 40%).
- Genetic and Environmental Factors Affecting Hair Density in East Asian Populations A 5,735-person East Asian study found three genetic loci shaping hair density, with one variant showing allele-specific effects on finasteride response in UK Biobank data.
- Efficacy of Oral Tofacitinib in Alopecia Areata, Alopecia Totalis, and Alopecia Universalis In a 50-patient interventional study, oral tofacitinib produced about 89% mean hair regrowth in alopecia areata, totalis, and universalis over 24 weeks.
- Evaluation of Efficacy of Water-Soluble Fraction of Rhus semialata Gall Extract and Penta-O-Galloyl-β-D-Glucose on Mitigation of Hair Loss: An In Vitro and Randomized Double-Blind Placebo-Controlled Clinical Study In lab cells and a placebo-controlled trial, Rhus semialata gall extract improved hair density and appearance scores versus placebo.
- Safety of Baricitinib in Adults with Severe Alopecia Areata from Two Phase III Trials Over a Median of 2.3 Years and Up to 4 Years of Treatment Pooled phase 3 data on baricitinib for severe alopecia areata show low serious-adverse-event rates and no new safety signals over up to 4 years, though longer-term data remain limited.
- Real-world Effectiveness and Safety of Janus Kinase Inhibitors in Alopecia Areata: A Retrospective Cohort Study of 72 Patients In a 72-patient real-world alopecia areata cohort, 61% achieved substantial regrowth on JAK inhibitors, with two serious adverse events in patients with pre-existing conditions.
- Effects of scalp lotion containing alpha lipoic acid derivatives for chemotherapy-induced alopecia in patients with gastrointestinal cancer: A prospective cohort study In 21 gastrointestinal-cancer patients, an alpha-lipoic-acid scalp lotion preserved hair diameter through three chemotherapy courses and prevented worsening alopecia grade; a randomized trial is warranted.
- Analysis on the treatment compliance of patients with androgenetic alopecia and its influencing factors: based on the comparison between microneedle therapy and drug therapy In 156 AGA patients, microneedling users adhered better than medication users; side effects and poor efficacy drove non-adherence in both groups.
- Evaluation of the efficacy of a biomimetic peptide solution for rejuvenation of donor scalp and as storage media for hair follicle grafts during FUE hair transplantation In 112 men undergoing FUE, adding QR678 Neo peptide solution to the transplant protocol improved regrowth, density and shaft diameter over conventional transplant.
- Understanding Eyebrow and Eyelash Involvement in Patients with Alopecia Areata and Responsiveness to Treatment with Baricitinib. Pooled phase 3 data show baricitinib 4 mg regrew eyebrows and eyelashes in alopecia areata far more often than placebo, tracking scalp response.
- Berberine promotes hair growth by targeting Axin2 and activating Wnt/β-catenin pathway In mice and human dermal papilla cells, berberine accelerated hair growth and prolonged anagen by targeting Axin2 and activating the Wnt/β-catenin pathway.
- The Relative Efficacy and Safety of Monotherapies for Alopecia Areata: A Network Meta‐Analysis Study A network meta-analysis ranked deuruxolitinib 12 mg twice daily the most effective monotherapy for alopecia areata, with FDA-approved JAK inhibitors showing dose-dependent efficacy.
- Exosomes from human umbilical cord mesenchymal stem cells promote the growth of human hair dermal papilla cells. In lab-grown human dermal papilla cells, umbilical cord stem cell exosomes boosted proliferation via PI3K/Akt pathway activation.
- Investigating the Relationship Between Androgenetic Alopecia and Hair Shape, Color, and Thickness: A Case‐Control Study In a 100-person case-control study, smoking, lighter hair colour and older age were associated with androgenetic alopecia; hair thickness and shape were not.
- The Future of Alopecia Treatment: Plant Extracts, Nanocarriers, and 3D Bioprinting in Focus A review covers plant extracts, nano drug-delivery systems, and 3D bioprinting as possible future alopecia treatments.
- Systemic Treatments for Lichen Planopilaris and Frontal Fibrosing Alopecia: A Retrospective Study of 315 Patients In 315 patients, methotrexate had the highest response for lichen planopilaris and retinoids for frontal fibrosing alopecia, with side effects limiting some drugs.
- Mir-574-3p and Mir-125a-5p in Adipose Derived Mesenchymal Stem Cell Exosomes Synergistically Target TGF-β1/Smad2 Signaling Pathway for the Treatment of Androgenic Alopecia In cell and mouse models, stem-cell exosome miRNAs miR-574-3p and miR-125a-5p acted together against TGF-β1/Smad2 signaling in androgenetic alopecia.
- JAK Inhibitors in African American Patients With Alopecia Areata: A Case Series a case series examines JAK inhibitors in African American patients with alopecia areata.
- Comparison of Dermatology Life Quality Index Scores in Adults and Adolescents with Alopecia Areata A chart review of 335 alopecia areata patients found adolescents reported significantly greater quality-of-life impact than adults despite similar hair-loss severity.
- Efficacy and safety of compound glycyrrhizin in patients with alopecia areata: a systematic review and meta-analysis A meta-analysis of 23 trials found compound glycyrrhizin added to conventional alopecia areata treatment improved cure and regrowth rates, with slightly more edema than controls.
- Exploring Factors That Influence the Measurement of Patient-Reported Impacts of Alopecia Areata Interviews with 30 alopecia areata patients found they needed 50-100% regrowth sustained for 6-12 months before reporting emotional or activity improvement.
- Alopecia Areata: Pathogenesis, Diagnosis, and Therapies A review summarizes current knowledge on alopecia areata's immune, genetic and environmental causes, diagnosis, and existing and emerging treatments.
- Preparation of hair follicle germs using centrifugal forces for hair regenerative medicine In mice, a centrifugation method prepared hair follicle germs that regenerated follicles more efficiently than conventional cell injections.
- Components of Severity in Alopecia Areata A survey found patient-rated alopecia areata severity was linked to facial hair loss and emotional and financial burden, not just scalp hair loss.
- Patient Validation of Estimation of Health Utility Values in Alopecia Areata UK patients with alopecia areata would trade roughly 5 of 10 life years to avoid severe scalp hair loss, confirming the disease's high burden.
- Management of folliculitis decalvans: The EADV task force on hair diseases position statement An EADV position statement recommends oral antibiotics for active folliculitis decalvans, isotretinoin first-line for mild disease, and lists further options.
- Hyaluronic Acid Microneedles Loaded with Chinese Herbal Extracts as an Intradermal Delivery System for Hair Regeneration Hyaluronic acid microneedles loaded with Platycladus orientalis extract delivered the extract into the dermis and activated Wnt/β-catenin signalling in preclinical tests.
- Identifying the Active Components and Mechanisms of Persicae Semen in Treating Androgenetic Alopecia: Insights from Network Pharmacology and Experimental Evaluations Network pharmacology and animal experiments suggest amygdalin from Persicae Semen promotes hair regrowth via androgen, Wnt and VEGF pathways.
- Minoxidil cyclodextrin inclusion complex-loaded microemulsions and transfersomes for androgen alopecia treatment: a comparative study In mice, a cyclodextrin microemulsion delivered minoxidil deeper into skin and promoted hair growth better than a transfersome formulation.
- Sexual Dysfunction in Alopecia Areata: A Systematic Review A systematic review of eight studies found alopecia areata negatively affects patients' sexual sphere and quality of life, but small samples limit conclusions.
- Pilot exploratory study to determine effect of fractionated CO2 laser to stimulate hair regrowth A pilot study examined whether fractionated CO2 laser can stimulate hair regrowth.
- Comparison of Graft Hair Dropout Rates Between Slit-Forceps Transplantation and Hair Transplanter Transplantation at 1 Month After Follicular Unit Excision A study compared graft hair dropout rates between slit-forceps and hair-transplanter methods one month after follicular unit excision.
- Apurinic/apyrimidinic endonuclease 1 (APE1) prevents alopecia by promoting regeneration of hair follicles Mice lacking the DNA-repair enzyme APE1 progressively lost all hair within 10 months, as bulge stem-cell proliferation failed through reduced β-catenin signaling.
- Modulating immune responses in alopecia: therapeutic insights and potential targets of antisense oligonucleotides A review links SIRT1 and antisense oligonucleotides targeting miR-485-3p to reduced inflammation and hair regrowth in murine alopecia models.
- Enhancing alopecia areata management: Nanocrystal-driven strategy for targeting hair follicles In ex vivo skin models, a clobetasol nanocrystal gel delivered four times more drug into hair follicles than conventional gel, with sustained release and lower systemic exposure.
- Potential Causal Relationship Between Extensive Lipid Profiles and Various Hair Loss Diseases: Evidence From Univariable and Multivariable Mendelian Randomization Analyses Mendelian randomization analyses suggest causal links between blood lipids and hair loss disorders, with HDL-C and triglycerides tied to alopecia areata.
- Hybrid function of light fraction patchouli oil in hair care formulations for effective hair and anti-dandruff treatment
- Safety First: A Comprehensive Review of Nutritional Supplements for Hair Loss in Breast Cancer Patients
- Enhancing hair growth through phytochemicals: mechanisms, supporting evidence, and future directions