December 202536
Photobiomodulation with 5% minoxidil was reported to cut telogen-phase hairs more than minoxidil alone in nine women with pattern hair loss. A trichoscopy-based hair fall atlas for Chinese men was validated with strong dermatologist agreement. Ritlecitinib in alopecia areata produced at least 50% regrowth in all JAK-inhibitor-naïve patients but only 23% of prior baricitinib users. A Chinese Delphi consensus defined severity-grading items and criteria for starting systemic treatment in alopecia areata. Low-dose topical resveratrol in mice was reported to protect against cyclophosphamide-induced hair loss by activating Shh signaling.
- Photobiomodulation therapy and 5% minoxidil in female pattern hair loss: a case series focusing on hair growth phases over a shorter timeframe In nine women with female pattern hair loss, adding red-light laser sessions to 5% minoxidil cut telogen-phase hairs more than minoxidil alone over 12.5 weeks.
- Establishment and validation of a hair fall atlas for Chinese men based on trichoscopy A 7-grade trichoscopy-based hair loss atlas for Chinese men was validated with strong dermatologist agreement in 400 participants.
- Expert consensus on systemic treatment activation and grading evaluation for alopecia areata A Chinese Delphi consensus defined severity-grading items and criteria for starting systemic treatment in alopecia areata, including intermediate SALT 20–50 cases.
- Ritlecitinib in Alopecia Areata: A 24‐Week Real‐World Experience Contrasting JAK Inhibitor‐Naïve and JAK Inhibitor‐Experienced Patients In 22 Japanese patients, ritlecitinib gave all JAK-inhibitor-naïve alopecia areata patients at least 50% regrowth but only 23% of prior baricitinib users, with no treatment-related adverse events.
- Combined Low Dose Oral Minoxidil and Immunomodulator Efficacy and Safety in Alopecia Areata: A Systematic Review a systematic review of the efficacy and safety of low-dose oral minoxidil combined with an immunomodulator for alopecia areata.
- Targeting sonic hedgehog (shh) signaling pathways by the concentration–dependent topical resveratrol for protection from cyclophosphamide-induced alopecia in a mouse model In mice, low-dose topical resveratrol protected against cyclophosphamide-induced hair loss by activating Shh signaling, outperforming minoxidil 2%.
- Sustaining treatment response in alopecia areata through tofacitinib dose tapering: A single-center retrospective study Retrospective study of 46 patients: tapering tofacitinib after complete regrowth kept alopecia areata controlled in 93.5% at 48 weeks.
- Effectiveness of baricitinib in severe alopecia areata in real life: a retrospective study of 87 patients. Retrospective study of 87 severe alopecia areata patients: 37% reached SALT <=20 after one year of baricitinib with no serious adverse events.
- Insights into the Diagnostics and Therapeutics of Alopecia Areata—An Indian Context A review of alopecia areata care in India finds dermoscopy the most practical diagnostic tool, with yellow dots and vellus hairs most sensitive and black dots most specific.
- Early prediction of alopecia areata using machine learning modeling of neuro stress immune signatures from multi datasets A machine-learning model using three genes predicted alopecia areata onset from gene-expression datasets, highlighting a neuro-stress-immune pathway.
- Optimized Nonshaven Follicular Unit Extraction Technique for Hair Transplantation in Long-Haired Patients describes an optimized nonshaven follicular unit extraction technique for long-haired transplant patients.
- Association of Serum IL-17A and IL-23 Levels With Alopecia Areata: A Cross-Sectional Comparative Study Serum IL-17A and IL-23 were elevated in alopecia areata; IL-17A rose with disease severity.
- Characterization of Epithelial Hair Follicle Stem Cells in Lichen Planopilaris and Folliculitis Decalvans Through Keratin 19 Expression a study characterizing epithelial hair follicle stem cells via keratin 19 in lichen planopilaris and folliculitis decalvans.
- Economic Burden of Alopecia Areata in the Kingdom of Saudi Arabia from a Societal Perspective: A Cost-of-Illness Analysis Cost-of-illness model: alopecia areata costs Saudi Arabia billions annually, driven mainly by productivity losses.
- Hyperbaric Oxygen Therapy for Enhanced Postoperative Recovery in Hair Transplantation In five FUE hair transplant patients, hyperbaric oxygen therapy cleared scabs within five days with 97-99% graft integration.
- H2AK119ub dynamics control hair follicle stem cell quiescence The histone mark H2AK119ub acts as a switch keeping hair follicle stem cells quiescent; its loss causes stem cell exhaustion.
- Preliminary comparison of scalp-sparing effects between 3DCRT and VMAT in pediatric and AYA craniospinal irradiation across photon energies: A phantom-based study In phantom models of pediatric craniospinal irradiation, VMAT spared the scalp better than 3DCRT, with 10 MV photons optimal.
- Patient Perspectives regarding Artificial Intelligence-Driven Trichoscopy for Alopecia Evaluation Survey of 101 alopecia patients: reviewing AI trichoscopy measurements increased treatment motivation for 54.5% and improved patient-doctor agreement.
- Az alopecia areata kezelésében alkalmazott baricitinib hatásosságának és biztonságosságának retrospektív vizsgálata In 30 Hungarian patients with severe alopecia areata, 63% reached near-full scalp coverage by 12 months on baricitinib, with mostly mild side effects.
- Efficacy of Local and Whole‐Body Phototherapy for the Treatment of Various Types of Alopecia Areata Retrospective study of 49 patients: phototherapy helped alopecia areata, especially early-onset cases and patients over 40.
- Ritlecitinib: Efficacy of a Novel Therapy for Severe Alopecia Areata in Patients Aged 12 Years and Older Review of ritlecitinib, a JAK3/TEC inhibitor approved for severe alopecia areata in patients 12 and older.
- Consensus Document on the Clinical Management of Frontal Fibrosing Alopecia: Recommendations From Spanish Working Group on Trichology and Onychology of the AEDV A Spanish expert consensus recommends starting frontal fibrosing alopecia treatment with oral dutasteride plus topical or intralesional agents, adding hydroxychloroquine if inflammation persists.
- Hair Transplant Donor Site Associated Hair Neogenesis: Quantitative Trichoscopy Results trichoscopy quantifies new hair growth at hair transplant donor sites.
- Gly-Pro-Val-Gly-Pro-Ser Low Molecular Weight Fish Collagen Peptide Promotes Hair Regeneration in Human Dermal Papilla Cells and C57BL/6 Mice. A fish collagen peptide boosted hair-growth factors and follicle size and density in human dermal papilla cells and mice.
- Relevance of topical application of minoxidil laden nano-lipid for hair growth enhancement A minoxidil nanoemulsion grew hair faster than conventional forms in mice and stayed stable for 12 months.
- Screening Potential Drugs From Nitric Oxide Donors for Treating Alopecia Based on Network Pharmacology and Experimental Validation Computer screening plus lab tests suggested the nitric oxide donor hesperidin may protect hair follicle cells from apoptosis and senescence.
- The prevalence of hair loss and its association with iron deficiency among adolescents in northern Sudan: a school-based cross-sectional study. Among 312 Sudanese adolescents, 21% had alopecia and iron deficiency was associated with roughly double the odds in a cross-sectional study.
- Therapeutic Approaches for Alopecia Areata in Children Aged 6 to 11 Years Review outlines management options for alopecia areata in children aged 6-11, where no systemic therapy is FDA-approved.
- Topical Cetirizine in Androgenetic Alopecia: A Preliminary Study
- Deciphering the Skin Anti-Aging and Hair Growth Promoting Mechanisms of Opophytum forskahlii Seed Oil via Network Pharmacology
- A case of dupilumab-induced psoriatic alopecia
- Causal effects of glutamine and lipid-related metabolites on alopecia areata: A 2-sample Mendelian randomization study
- Efficacy and Tolerability of Oral Bicalutamide in Forty Postmenopausal Women With Female Pattern Hair Loss: A Retrospective Study
- Patients treated with thinner artificial hair implants: a case series
- Efficacy and safety of topical GT20029 in male patients with androgenetic alopecia: a multicenter, randomized, double-blind, placebo-controlled phase 2 study
- Metabolic and Vascular Inflammation in Alopecia Areata: Linking Uric Acid, Lipid Imbalance and ICAM ‐1 Upregulation