January 202615
Injectable therapies for pattern hair loss were found to possibly improve density, with dutasteride prominent, though evidence was judged too heterogeneous for routine use. Dietary supplements for pattern hair loss were found to improve density versus placebo in a network meta-analysis, including Nutrafol, pumpkin seed oil and tocotrienols. Bacillus fermentation products enhanced minoxidil skin penetration and regrowth in mice. An adenosine cocrystal delivery system promoted follicle growth in preclinical tests. Autologous γδ regulatory T cells restored follicle immune privilege and regrowth in human alopecia areata skin models.
- Injectable Therapy for Androgenetic Alopecia: A Systematic Review A systematic review found injectable therapies for pattern hair loss—especially dutasteride—may improve density, but evidence is too heterogeneous for routine recommendation.
- Effects of dietary supplements on androgenetic alopecia: a systematic review and network meta-analysis A network meta-analysis of 19 RCTs found Nutrafol, pumpkin seed oil, tocotrienols and other supplements improved hair density versus placebo, with good tolerability.
- Toward cell-based therapy of alopecia areata: Autologous human Vδ2+ Foxp3+ γδTreg cells restore hair-follicle immune privilege and promote hair regrowth in human alopecia areata models ex vivo and in vivo In human alopecia areata skin models, injected autologous Vδ2+ γδ regulatory T cells restored follicle immune privilege, prevented onset, and promoted regrowth.
- Multi-targeted synergy of Bacillus sp. TC5 fermentation products for transdermal drug delivery and hair regeneration Bacillus sp. TC5 fermentation products enhanced skin penetration of minoxidil and promoted hair regrowth in mice via Wnt10b/β-catenin and VEGF/IGF-1 pathways.
- Deuruxolitinib for Alopecia Areata. A review covers deuruxolitinib, the third oral JAK inhibitor FDA-approved (July 2024) for severe alopecia areata, including efficacy and safety data.
- Supramolecular adenosine-based skin delivery system for hair regulation and restoration A supramolecular adenosine cocrystal delivery system promoted hair follicle growth in preclinical tests, with reported clinical safety and anti-hair-loss efficacy.
- Yangxuebushen Decoction prevents cyclophosphamide-induced hair loss by inhibiting hair follicle apoptosis In mice with cyclophosphamide-induced hair loss, a Chinese herbal decoction reduced follicle apoptosis and inflammation, raising anagen follicles from 15% to 30%.
- Topical Metformin Compared with Clobetasol Propionate for Alopecia Areata: Clinical Outcomes from a Comparative Study. In a 34-patient trial for patchy alopecia areata, topical metformin 30% regrew hair comparably to clobetasol, though clobetasol reduced SALT scores more.
- Comparative in vivo assessment of hair-growth efficacy using nanostructured lipid carriers individually loaded with lavender oil or tea seed oil In rats, nanostructured lipid carriers carrying lavender or tea seed oil increased hair length about 120–132% over placebo after 30 days.
- Exosomal miRNA-218–5p derived from low-passage dermal papilla cells modulates hair follicle growth and development Lab study: exosomal miR-218-5p from low-passage dermal papilla cells stimulated hair follicle stem cell proliferation and promoted growth in cultured follicles.
- Risk Factors for Pediatric Alopecia Areata: Clinical and Biochemical Findings from a Case – Control Study In 200 pediatric alopecia areata cases, low vitamin B12 and ferritin were independent risk factors; vitiligo, asthma, ADHD were more frequent.
- Factors Associated with the Severity of Female Pattern Hair Loss: A Retrospective Study In 289 women with pattern hair loss, only longer disease duration—not vitamin, mineral, or hormone levels—independently predicted greater severity after adjustment.
- THE EFFECTS OF ROSMARINUS OFFICINALIS ON VEGF AND IL-1Α GENE EXPRESSIONS IN HACAT CELLS: UNRAVELING ITS MECHANISM OF ACTION IN WOUND HEALING AND HAIR LOSS. In cultured human keratinocytes, rosemary extract significantly upregulated VEGF but did not significantly change IL-1α expression.
- Convergent Regenerative Strategies in PM&R for Musculoskeletal and Hair Restoration: Integration of PRP, Exosomes, and Physical Modalities A review links PRP, exosomes and laser therapy across musculoskeletal and hair regeneration via shared pathways like Wnt/β-catenin, noting standardization gaps.
- An Exploratory Preclinical In Vivo Pilot Study Evaluating the Hair Growth–Promoting Effects of Rosmarinus officinalis and Ricinus communis Combination In a 15-mouse pilot, a rosemary–castor oil combination trended similarly to 2% minoxidil for hair growth; tiny sample precludes firm conclusions.