August 202626
A systematic review finds combining monthly PRP with daily minoxidil outperforms either alone for androgenetic alopecia. For female pattern hair loss, spironolactone above 100 mg daily beat bicalutamide in a retrospective comparison. A safety review of hair restoration procedures found minor infection and folliculitis were most frequent, with rare necrosis, though heterogeneous reporting limits firm incidence estimates. Topical bimatoprost reached efficacious scalp concentrations in men with androgenetic alopecia. A review found adipose stem-cell secretome may improve hair density, particularly with microneedling. Among GLP-1 users, semaglutide and tirzepatide were associated with higher odds of nonscarring hair loss, an association rather than proof of cause.
- Nonscarring Alopecia in Adults Treated With GLP ‐1s: A Propensity Score Matched TriNetX Cohort Study In a large propensity-matched cohort, semaglutide and tirzepatide were associated with higher odds of telogen effluvium and other nonscarring hair loss; the authors suggest weight-loss stress may contribute, an association rather than proof of cause.
- Efficacy and Safety of Platelet-Rich Plasma Versus Topical Minoxidil in Androgenetic Alopecia: A Systematic Review Systematic review of four RCTs: combining monthly PRP with daily 5% minoxidil outperformed either alone, with only minor local side effects.
- Safety Considerations in Hair Restoration Procedures: A Comprehensive Review A scoping review of hair transplant complications: minor infection 1.4-2%, folliculitis 1.1-12.1%, rare necrosis and arteriovenous fistulas; definitions and reporting were heterogeneous, limiting firm incidence estimates.
- Spironolactone versus Bicalutamide for Female Pattern Hair Loss: A 24-Month Unicenter Retrospective Comparative Study of Effectiveness and Safety Retrospective 24-month study of 187 women: spironolactone, especially above 100 mg/day, beat bicalutamide for female pattern hair loss with comparable safety and less monitoring.
- Local Pharmacokinetics and Tolerability of Topically‐Applied Bimatoprost to the Scalp of Male Patients With Androgenetic Alopecia In 11 men with androgenetic alopecia, topical bimatoprost 1% reached subcutaneous levels above in-vitro efficacious concentrations and was well tolerated over 14 days.
- Alopecia Areata: Current and Emerging Therapies A review of alopecia areata therapy: approved JAK inhibitors give regrowth that deepens over time, but many patients respond incompletely.
- Hair regeneration in alopecia using adipose-derived mesenchymal stem cells secretome: A systematic review of experimental and clinical evidence A systematic review finds adipose stem-cell secretome may improve hair density, especially with microneedling, but evidence remains preliminary and heterogeneous.
- Upadacitinib for Severe Alopecia Areata in Adults and Adolescents Two phase 3 trials: upadacitinib achieved SALT 20 or less at week 24 in 45-55% of severe alopecia areata patients versus 1.5-3.4% on placebo.
- Ginkgolide B-loaded detachable microneedles attenuate androgenetic alopecia by suppressing endoplasmic reticulum stress via the Nrf2/HO-1 pathway In DHT-induced hair-loss mice, ginkgolide B microneedles eased follicle endoplasmic-reticulum stress via Nrf2/HO-1 and outperformed minoxidil.
- PD-L1 vNAR promotes hair growth by modulating hair shaft elongation through activating the leptin-STAT3 signaling In mice, a shark-derived PD-L1 antibody promoted hair growth via leptin-STAT3 signaling, and sponge-spicule transdermal leptin delivery enhanced the effect.
- Diet‐Induced Obesity Promotes Alopecia Through Oxidative Stress and Androgen Signalling in Female Mice In female mice, high-fat-diet obesity worsened hair loss via oxidative stress and androgen signaling; N-acetylcysteine, finasteride, or spironolactone each ameliorated thinning.
- Alopecia areata: Emerging therapies and up-to-date management strategies A review offers a stepwise alopecia areata management framework built around the three approved JAK inhibitors, with guidance on switching after nonresponse.
- Improved transcutaneous delivery of cetirizine hydrochloride for the treatment of post-chemotherapy alopecia: Poke and emulgel approach In rats, a cetirizine emulgel applied to microneedle-pretreated skin promoted regrowth after cyclophosphamide-induced hair loss.
- Az androgén alopecia korszerű kezelése A Hungarian-language review comparing international androgenetic alopecia guidelines; topical minoxidil and 5-alpha-reductase inhibitors remain cornerstones.
- Can Transplanted Hair Follicles Survive in the Absence of Arrector Pili Muscle Attachments? Small biopsy study: transplanted follicles survived despite absent normal arrector pili muscle attachments.
- Understanding Alopecia Areata: An Integrative Review of Causes, Mechanisms, and Management Strategies A review of alopecia areata causes and treatments, from JAK inhibitors to exosomes, advocating personalized therapy.
- Fabrication and Characterization of 3BDO-Loaded Dissolvable Microneedle Patches for Hair Regrowth in C57BL/6 Mice A protocol for 3BDO-loaded dissolving microneedle patches showed more uniform hair regrowth than injection in mice.
- Hair loss A review for physician associates outlines pattern-based diagnosis and cause-specific treatment of common hair loss.
- Hair vaccine: Myth or future therapeutic reality? Immunopharmacological perspectives on immune-regenerative strategies for hair loss A review concludes no true hair vaccine exists, though vaccine-inspired immune-regenerative strategies show preclinical promise.
- Hair Growth-Supporting and Follicle-Protective Potential of a Botanical-Based Supplement Ingredient: In Vitro, Ex Vivo, and Molecular Docking Studies In-vitro work suggests a polyphenol supplement ingredient may dock on SRD5A2 and protect follicles; clinical studies are lacking.
- Systematic review of efficacy of hair transplantation in patients with classic lichen planopilaris and frontal fibrosing alopecia: revisiting the current evidence Systematic review: hair transplants in lichen planopilaris show good early graft survival but decline after two years.
- EGCG-Biotin-Pal-GHK composition modulates TGF-β and BMP pathways in scalp microenvironment for treating stress-induced alopecia In a stress-induced fibrotic alopecia mouse model, an EGCG-biotin-Pal-GHK combination reduced follicle fibrosis and improved regrowth.
- Potential of Hair Follicle Stem Cell-Derived Exosomes Carrying miR-181a-5p to Promote the Telogen-to-Anagen Stage In mice, follicle stem-cell exosomes enriched with miR-181a-5p accelerated the telogen-to-anagen transition, reaching about 90% hair coverage by day 15.
- Systemic Comorbidities in Central Centrifugal Cicatricial Alopecia: A Systematic Review and Meta-analysis Meta-analysis: central centrifugal cicatricial alopecia is associated with dyslipidemia, uterine fibroids, and anxiety disorders.
- Real‐World Outcomes and Safety of JAK Inhibitors in Paediatric Alopecia Areata: A Retrospective Multicentre Study Real-world multicentre study: most children with alopecia areata improved on JAK inhibitors with mostly mild adverse events, but the observational design precludes causal or between-drug conclusions.
- Baricitinib versus ritlecitinib for severe alopecia areata: A 24‐week real‐world study