April 202612
A Delphi consensus on hair aging defined senescent alopecia as diffuse thinning distinct from pattern loss, and minoxidil was reported the only drug to win consensus support. A review of AGA in transgender patients found oral minoxidil a cornerstone therapy, with 5-alpha-reductase inhibitors relevant mainly for transgender men. A review of exosomes in hair restoration reported enhanced follicle regeneration in preclinical studies, though dosing and protocols remain unestablished. In animals, a suction-cup microneedle nano-drug system was reported to treat androgenetic alopecia. In lab work, p53 activation was reported to guard the hair follicle against chemotherapy-induced alopecia.
- Hair Aging Revisited: An Expert Delphi Consensus on Pathogenesis, Clinical Features, and Future Therapies Delphi consensus on hair aging: senescent alopecia defined as diffuse thinning distinct from AGA, and minoxidil was the only drug to win consensus support.
- Characterization and Management of Androgenetic Alopecia in Transgender and Gender-Diverse Individuals: A Narrative Review Review of AGA in transgender patients: oral minoxidil is a cornerstone therapy; 5-alpha-reductase inhibitors matter mainly for transgender men, benefit uncertain in transgender women.
- Hitting pause on chemotherapy-induced alopecia: transient p53 activation as a guardian of the hair follicle placeholder
- Bio-inspired suction cup microneedle loaded fusion membrane targeting nano-drug delivery system treat androgenetic alopecia placeholder
- Living Probiotic Microneedles Coordinate Antiandrogen and Nitric Oxide Therapy for Androgenetic Alopecia Dissolvable microneedles carrying nitric oxide-producing probiotic and clascoterone improved hair density and reduced inflammation in testosterone-treated mice.
- Persistent Chemotherapy-Induced Alopecia: Updates in Diagnosis and Treatment Persistent Chemotherapy Induced Alopecia: An Updated Approach A review of persistent chemotherapy-induced alopecia covering diagnosis, scalp cooling prevention, and topical or low-dose oral minoxidil for regrowth.
- Exosomes in Hair Restoration Review: exosomes enhance follicle regeneration in preclinical studies with encouraging early clinical data, but dosing and protocols remain unestablished.
- Assessment of vitamin D levels in patients with alopecia areata: a case-control study in a Tertiary Care Hospital in North India Case-control study in North India: vitamin D deficiency was linked to 3.2-fold higher odds of alopecia areata but did not correlate with severity.
- Targeted transferosomal delivery of cetirizine: A new approach to alopecia management Cetirizine-loaded transferosomes enhanced hair growth and raised IGF-1 and VEGF levels in mice.
- FLIM Reveals Red Light-Induced Changes in Murine Hair Follicles In mice, 650 nm red light increased follicle numbers and ATP, and FLIM imaging tracked the metabolic changes behind low-level laser therapy.
- Ageratum houstonianum Extract and Agerarin Promote Hair Growth via MAPK/AP-1 Axis-Dependent Upregulation of SCUBE3 in Human Dermal Papilla Cells Ageratum houstonianum extract and agerarin promoted hair shaft elongation in human follicle cultures by upregulating SCUBE3 via the MAPK/AP-1 pathway.
- Age-related downregulation of dihydrotestosterone-inactivating enzymes in human scalp sebaceous glands Lab study: DHT-inactivating AKR1C enzymes concentrate in sebaceous glands and decline with age; sulforaphane upregulates them in cultured cells.