September 202633
A 10-year randomized trial of PRP found hair density rose 31% at 12 months and stayed above baseline at 5 years with maintenance. In men with inadequate response to standard therapy, higher-dose dutasteride around 0.87 mg daily showed clinical benefit over 14 months. An international Delphi consensus endorsed low-dose oral minoxidil in children aged 4-11 with weight-based dosing and reassessment every 3-6 months. Two reviews address hair loss during obesity treatment and GLP-1 agonist hair loss, mainly telogen effluvium from rapid weight loss, though mechanisms remain incompletely established. A phase 2 trial found deuruxolitinib 8 mg twice daily beat 16 mg once daily for alopecia areata. A clinical review offers guidance on JAK inhibitors in pediatric alopecia areata. Pharmacovigilance analysis found infertility signals for finasteride, dutasteride and minoxidil, strongest for finasteride, though signals indicate reports not causality.
- Low-Dose Oral Minoxidil Use for Pediatric Hair Disorders An international Delphi consensus supports low-dose oral minoxidil for children aged 4-11 with weight-based dosing of 0.25-1.875 mg/day and reassessment every 3-6 months.
- The safety and efficacy of doses higher than 0.5 mg/day of dutasteride in male androgenic alopecia In 17 men with inadequate response to standard dutasteride, escalating to about 0.87 mg/day was assessed for safety and showed clinical benefit over 14 months.
- Hair loss during treatment of obesity: current state of the problem and potential solutions An expert review covering hair loss from weight-loss treatments including GLP-1 agonists, discussing mechanisms and prevention through nutritional support.
- Long-Term Clinical Outcomes of Autologous Nonactivated Platelet-Rich Plasma Delivered Through Mechanical and Controlled Infiltration in Male and Female Androgenetic Alopecia: A 10-Year Prospective Randomized Evaluator-Blinded Study A 234-patient 10-year trial found PRP increased hair density 31% at 12 months, remaining above baseline at 5 years with maintenance treatment.
- Hair and scalp effects of glucagon-like peptide-1 receptor agonists in practice A review of GLP-1 agonist hair loss affecting 3-5% of users, mainly telogen effluvium from rapid weight loss, with protein intake and minoxidil management strategies; mechanisms remain incompletely established.
- Androgenetic alopecia drugs and male infertility: Evidence from pharmacovigilance and testicular transcriptomics Pharmacovigilance analysis found infertility reporting signals for finasteride, dutasteride and minoxidil, strongest for finasteride; signals indicate reports not incidence or causality, and the transcriptomic findings are hypothesis-generating only.
- Prevalence of metabolic syndrome in patients with androgenetic alopecia: an analysis of current evidence Meta-analysis of 28 studies found metabolic syndrome in about 24% of androgenetic alopecia patients, rising with AGA severity, though estimates varied widely.
- Synbiotic HQP08 Supplementation for Hair Loss and Depressive Symptoms: An Open-Label Pilot Study of Clinical Outcomes and Gut Microbiome Changes An open-label pilot of 32 adults found synbiotic HQP08 reduced hair shedding and depressive symptoms over 8 weeks; randomized trials needed.
- Synergistic chitosan nanoparticles loaded with baricitinib for the management of persistent chemotherapy-induced alopecia Baricitinib-loaded chitosan nanoparticles enhanced dermal drug deposition and protected against chemotherapy-induced alopecia in mice.
- Bulge Progenitor Cells: A Promising Frontier in Hair Follicle Regeneration and Clinical Translation A review of bulge progenitor cells for hair regeneration noting early trials showing 20-30% hair density increases in androgenetic alopecia.
- Subpericranial and epidural abscess with skull osteomyelitis as a complication of microneedling for alopecia: A singular case report A 28-year-old self-treating with minoxidil and microneedling developed a skull abscess and osteomyelitis requiring surgery; a cautionary case about home derma-rolling hygiene, though single-patient.
- T-cells may represent a novel biomarker for female pattern hair loss Immunohistochemical study characterizing T-cell infiltrates in female pattern hair loss versus telogen effluvium as a potential biomarker.
- Contact hypersensitivity promotes hair regeneration through SPP1-secreting macrophages Mouse study reveals SPP1-secreting macrophages trigger hair follicle stem cell proliferation via CD44, a new regeneration mechanism.
- Dose optimization of deuruxolitinib in adults with alopecia areata: A phase 2 randomized trial Phase 2 trial of 57 severe alopecia areata patients: deuruxolitinib 8 mg twice daily beat 16 mg once daily, with 46% vs 18% SALT improvement at week 24.
- Pediatric alopecia areata and JAK inhibitors: Bridging the gap between evidence and practice A clinical review providing practical guidance on JAK inhibitor selection, dosing and monitoring for pediatric alopecia areata.
- Extracellular Vesicles for Androgenetic Alopecia: Current Evidence, Mechanisms, and Clinical Prospects A review of extracellular vesicle therapies for androgenetic alopecia, noting convergent Wnt mechanisms but predominantly preclinical evidence.
- JAK Inhibitors for Alopecia Areata: Approved Therapies, Efficacy, and Unanswered Questions A review of approved JAK inhibitors for alopecia areata noting 40-50% efficacy in phase 3 trials, with comparative efficacy limited to indirect cross-trial comparisons.
- Eggshell Membrane (Ovoderm ® -AS) Promotes Hair Growth via Upregulation of Growth Factors and Wnt/β-Catenin-Related Gene Expression in Mice Oral eggshell membrane promoted hair regrowth in mice via growth factor upregulation and Wnt/beta-catenin signaling.
- Central Centrifugal Cicatricial Alopecia in Black Women: Diagnostic Challenges and Molecular Insights A review of central centrifugal cicatricial alopecia highlighting diagnostic challenges and molecular pathways in Black women.
- Hair Growth-Promoting Effect of a Horse Oil–Folium Isatidis Topical Preparation via Modulation of VEGF, TGF-β1, and β-Catenin Signaling in C57BL/6 Alopecia Mice: A Pilot Study A horse oil-Folium Isatidis topical preparation promoted hair growth in mice via VEGF/beta-catenin activation.
- Comorbidities in frontal fibrosing alopecia and lichen planopilaris: A systematic review and meta-analysis A systematic review characterizing comorbidities in frontal fibrosing alopecia versus lichen planopilaris.
- Navigating Treatments in Folliculitis Decalvans: A Comprehensive Systematic Review A systematic review of 300 folliculitis decalvans patients found rifampicin-clindamycin gives initial response with frequent relapse; isotretinoin showed durable remission up to 82%.
- Hair transplantation in scar reconstruction A narrative review of hair transplantation for reconstructing scar alopecia from burns or trauma.
- Mixed-Culture Fermentation of Coffee Pulp Induces Metabolomic Changes and Enhances Multi-Target Bioactivity Relevant to Androgenetic Alopecia Fermented coffee pulp extracts modulated multiple AGA-relevant genes in human dermal papilla cells in the lab.
- High-resolution ultrasound in alopecia: Principles, sonoanatomy, and imaging patterns A review of high-resolution ultrasound findings across scarring and non-scarring alopecias as a diagnostic complement.
- Telogen Effluvium: Six Days of Patient Documented Hair Loss
- Impact of baricitinib on thyroid function and autoimmunity in severe alopecia areata: A pilot study
- Leptin receptor overexpression in the infundibulo‐isthmic region of frontal fibrosing alopecia
- Religious and Cultural Head Coverings and Risk of Traction Alopecia: A Systematic Review
- Perifollicular Repigmentation After Hair Transplant in Stable Discoid Lupus Erythematosus
- Occipital hairline changes in women with frontal fibrosing alopecia receiving low-dose oral minoxidil
- A causal effect of increased GLP1R expression on male-pattern hair loss is suggested by 2-sample Mendelian randomization
- Commentary on: Hair transplantation in scar reconstruction