February 20266
In a randomized trial, bicalutamide versus spironolactone in women was found to improve hair density and shaft diameter more than spironolactone, though clinical endpoints did not differ significantly. A review concluded rosemary extract for hair growth improved hair density and thickness in clinical trials and may be a natural alternative to minoxidil. In a placebo-controlled trial, a saw palmetto extract was reported to increase terminal hair count and density in adults with self-perceived thinning. A case-control study found trichoscopic signs in female pattern hair loss distinguished it from chronic telogen effluvium and supported a risk-prediction model. In mice, exosomes carrying EGF and FGF were reported to restore hair density and follicle structure.
- Spironolactone vs. bicalutamide in female pattern hair loss: a randomized clinical trial In a 188-woman randomized trial, bicalutamide 50 mg improved hair density and shaft diameter more than spironolactone 100 mg over 24 weeks, though clinical endpoints did not differ significantly.
- Review on natural remedies for hair growth promotion with a focus on rosemary A review concludes rosemary extract improved hair density and thickness in clinical trials and may be a natural alternative to minoxidil, while urging more long-term research.
- The Safety and Efficacy of a Novel Saw Palmetto ( Serenoa repens ) Extract for Promoting Hair Growth in Adults With Self‐Perceived Thinning Hair: 180‐Day Results In a 6-month placebo-controlled trial of 60 adults, a proprietary saw palmetto extract significantly increased terminal hair count and density with no treatment-related adverse events.
- Trichoscopic Features, Clinical Correlates, and Risk Prediction in Female Pattern Hair Loss: A Retrospective Case-Control Study A case-control study of 302 women identified trichoscopic signs distinguishing female pattern hair loss from chronic telogen effluvium and built a risk-prediction model.
- Engineered Exosomes Co-Delivering EGF and FGF Ameliorate Androgenetic Alopecia in a Mouse Model Exosomes engineered to carry EGF and FGF restored hair density and follicle structure in a mouse model of androgenetic alopecia without toxicity.
- Upadacitinib for the Management of Alopecia Totalis and Subtotalis in Pediatric Patients: A Case Series In eight children aged 9-14 with alopecia totalis, upadacitinib 15 mg daily produced complete or near-complete regrowth in most, with only mild acne reported.