July 202552
Hair transplant tourism was reported to pair low prices with permissive regulation, unsupervised technicians and unreported complications. PRP combined with 5% minoxidil was found to improve hair parameters more than either alone. Microtrauma therapies including microneedling and lasers were reported to promote regrowth through wound-healing responses. Topical minoxidil was reported to add about 21 hairs/cm², with oral and topical working similarly. A comprehensive prevention protocol after transplantation was reported to cut postoperative edema from 8.94% to 2.66% with no severe cases. Telogen effluvium in balding men was reported to precede follicle miniaturization. Microneedling radiofrequency with topical exosomes was reported to increase hair density and diameter. A 1565-nm fractional laser was reported to visibly improve scalp hair appearance. Fecal microbiota transplantation in mice was reported to promote hair growth.
- Association Between Androgenetic Alopecia and Glucagon‐Like Peptide‐1 Receptor Treatment in Type 2 Diabetes Mellitus Patients: A Retrospective Cohort Study a retrospective cohort study examines whether GLP-1 receptor agonist treatment is associated with androgenetic alopecia in type 2 diabetes patients.
- The Allures and the Alarms of the Hair Transplant Tourism Industry A review warns hair transplant tourism offers low prices but permissive regulation, unsupervised technicians, bait-and-switch marketing and unreported complications leave patients vulnerable; international standards are urged.
- Effects of platelet-rich plasma application on hair follicle count, telogen/anagen ratio, and miniaturized hair ratio in patients with androgenic alopecia: alone or in combination with other treatments A retrospective comparison found PRP combined with 5% minoxidil improved hair parameters more than either treatment alone in androgenetic alopecia, especially reducing vellus hair.
- The role of microtrauma in hair regrowth and regeneration in non-scarring alopecia. A review finds microneedling, lasers, low-level laser therapy and PRP promote regrowth through wound-healing immune responses, with demonstrated efficacy in androgenetic alopecia and alopecia areata.
- Comprehensive Prevention for Edema after Hair Transplantation: A Multicenter Study of 1167 Patients In 1167 hair-transplant patients, a comprehensive prevention protocol cut postoperative edema from 8.94% to 2.66% with no severe cases, versus triamcinolone tumescent solution.
- Topical minoxidil for androgenetic alopecia: When blood pressure agents make you hairy. A review: topical minoxidil adds about 21 hairs/cm² versus 5–9 with placebo over 16–48 weeks; oral and topical minoxidil work similarly with different side effects.
- You cannot go bald without first, losing your hair: Telogen effluvium is a precursor to, prerequisite for and potentially an incitant to common baldness in men In balding men, shortening of the anagen growth phase (telogen effluvium) precedes follicle miniaturization, suggesting shedding is an early step toward pattern baldness.
- Is Intralesional Methotrexate an Effective Alternative to Intralesional Triamcinolone in Alopecia Areata? Findings From a Randomized Controlled Trial In a 40-patient randomized trial, triamcinolone injections improved patchy alopecia areata (SALT scores down 54%) while intralesional methotrexate patients worsened.
- Fecal microbiota transplantation promotes hair growth through gut microbiome and metabolic regulation Genetic analysis linked low gut Lactobacillus to androgenetic alopecia, and in mice fecal transplant and L. rhamnosus GG promoted hair growth.
- Fucoidan treatment reverses hair loss and inhibits inflammatory responses in a mouse model of androgenetic alopecia In a mouse model of androgenetic alopecia, 2% fucoidan reversed hair loss and increased density via Wnt/β-catenin signaling, VEGF release, and reduced inflammation.
- Microneedling radiofrequency followed by topical exosome application therapy for pattern hair loss: a scoping review and prospective study. In 20 patients, microneedling radiofrequency followed by topical exosomes significantly increased hair density and diameter over nine months, with no adverse events; RCTs are still needed.
- Bifunctional sodium hyaluronate microneedle patches integrating 5α-reductase and ROS regulation for boosted hair regeneration In cells and mice, a hyaluronate microneedle patch combining dutasteride micelles and antioxidant nanoparticles lowered DHT and ROS and accelerated hair growth.
- Treatment outcomes and considerations for topical immunotherapy in patients with alopecia totalis and alopecia universalis In 106 patients with alopecia totalis or universalis, topical immunotherapy gave excellent or good responses in 43%; atopic dermatitis predicted poorer outcomes.
- Efficacy and safety of Cinainu in paediatric alopecia areata: an international, double-blind, randomized, placebo-controlled, phase II/III trial In a 107-child trial, topical botanical Cinainu beat placebo for moderate-to-severe alopecia areata at 24 weeks, with benefits sustained to 48 weeks and good tolerability.
- Sinapic acid and glabridin synergistically mitigate androgenetic alopecia by modulating ferroptosis through stabilization of β-catenin against ubiquitin-dependent degradation. In AGA mice, sinapic acid plus glabridin synergistically promoted hair growth by blocking ferroptosis and stabilizing β-catenin in dermal papilla cells.
- Optimizing Efficacy: Hyaluronic Acid Liposomes Encapsulating Minoxidil for Enhanced Transdermal Delivery and Treatment of Androgenetic Alopecia In mice, a hyaluronic-acid liposome minoxidil formulation improved skin penetration and retention, reduced inflammation, and accelerated hair growth versus standard delivery.
- Improvement in Scalp Hair Appearance Following Treatment With a Non‐Ablative Fractional Laser: A Retrospective Observational Study In a 132-patient retrospective study, blinded reviewers correctly identified post-treatment photos 96.9% of the time after 1565-nm fractional laser for AGA.
- Cancer-Related Alopecia Risk and Treatment Opinion review: scalp cooling first-line to prevent chemotherapy hair loss, topical minoxidil for regrowth; oral minoxidil urged cautiously until oncology safety data are available.
- Hair Transplant: Patient Candidacy, Medical Optimization, and Surgical Considerations A review covers how to select hair transplant candidates, optimize medical therapy beforehand, and manage surgery and postoperative complications.
- The GPR30 agonist G-1 promotes hair growth via Wnt/Hedgehog signaling in mice In mice and human dermal papilla cells, GPR30 agonist G-1 activated Wnt/Hedgehog signaling and promoted hair growth, suggesting a novel estrogen-pathway target.
- Frontiers in the physiology of male pattern androgenetic alopecia: Beyond the androgen horizon A review examines what drives male pattern hair loss beyond androgen signaling and maps open questions and potential future drug targets.
- Real-world assessment of ritlecitinib in patients with severe alopecia areata: a 24-week multicentre retrospective study Real-world ritlecitinib for severe alopecia areata produced higher SALT20 response rates than the pivotal ALLEGRO trial, a three-center Italian review found.
- Platelet-Rich Plasma Treatment for Endocrine-Induced Alopecia and Persistent Chemotherapy-Induced Alopecia in Breast Cancer Survivors: A Randomized, Controlled, Pilot Study In a pilot RCT, PRP raised hair density in breast cancer survivors with endocrine- or chemo-induced alopecia, but no more than untreated scalp; no tumor seeding was observed.
- Safety of Alopecia Treatments in Patients with Breast Cancer and High-Risk Women: A Review A review assessing which alopecia areata, androgenetic alopecia, and scarring alopecia medications are safe for breast cancer patients and high-risk women.
- Serotonin activates dermal papilla cells and promotes hair growth In hair follicle organoids and organ cultures, serotonin and the agonist sumatriptan promoted hair shaft elongation.
- Alopecia Treatments in Breastfeeding: Safety and Clinical Considerations A review mapping which alopecia areata, androgenetic alopecia, and scarring alopecia treatments transfer into breast milk and their potential infant effects.
- Single‐Cell RNA Sequencing Highlights a Contribution of Human Amniotic Mesenchymal Stem Cells‐Derived Exosomes to Androgenetic Alopecia In AGA mice, human amniotic stem-cell exosomes accelerated hair growth by protecting dermal papilla cells from DHT damage via Wnt/β-catenin signaling.
- Therapeutic Burden as Predictor of Response to Baricitinib for Alopecia Areata in Real Life: Prospective Study In 44 patients, fewer prior systemic treatments (low therapeutic burden) predicted significantly better response to baricitinib for alopecia areata over 12 months.
- Prevention of chemotherapy drug-mediated human hair follicle damage: combined use of cooling with antioxidant suppresses oxidative stress and prevents matrix keratinocyte cytotoxicity In human hair follicle cultures, adding antioxidants like N-acetylcysteine to scalp cooling prevented chemotherapy-induced follicle damage even at suboptimal cooling temperatures.
- Modified Huanjingjian Prevents Chemotherapy-Induced Alopecia by Inhibiting Genomic DNA Methylation of the Wnt Signaling Pathway in Mice In mice, a modified Chinese herbal formula prevented cyclophosphamide-induced hair loss by reactivating Wnt signaling through DNA demethylation in follicle stem cells.
- Activity‐based therapeutic algorithm for folliculitis decalvans: A practical tool for effective management proposes an activity-based therapeutic algorithm as a practical tool for managing folliculitis decalvans.
- Statement from the frontal fibrosing alopecia international expert alliance: SOFFIA 2024 A 69-expert Delphi consensus on frontal fibrosing alopecia agreed on only 56% of questions, with strongest agreement on disease monitoring and weakest on physical therapies.
- [Artículo traducido] Comparación entre la aplicación subcutánea vs. subcutánea e intramuscular combinada de toxina botulínica para el tratamiento de la alopecia androgenética: un ensayo clínico aleatorizado A randomized trial found a single botulinum toxin session, subcutaneous or combined, did not improve hair density or quality in men with AGA at six months.
- Alopecia Areata Associated with Dupilumab: National Database Study In a matched database study, dupilumab users with atopic dermatitis had modestly higher alopecia areata risk (OR 1.44); authors urge scalp monitoring but call for confirmatory research.
- Comparative analysis of 3D and 2D cell-culturing methods in hair follicle spheroid morphogenesis and drug responsiveness In lab cultures, 3D hair-follicle spheroids responded as expected to minoxidil, but 2D cultures responded better to DHT.
- Regenerative<sup>®</sup> Hair Transplant: Innovation in Hair Transplantation Regenerative<sup>®</sup> Hair Transplant. A technique combining hair transplant with autologous mesenchymal stem-cell injection; authors claim better density but report only cell characterization, no patient outcomes.
- Single-cell sequencing combined with spatial transcriptomics reveals the characteristics of follicle-targeted inflammation patterns in primary cicatricial alopecia Single-cell and spatial sequencing of lichen planopilaris scalp identifies interferon-γ and macrophage-derived oncostatin M as drivers of follicular scarring and potential drug targets.
- A Brief Review of Scalp Biopsy and its Interpretation A review giving practical recommendations on scalp biopsy site choice, technique, and interpretation for diagnosing alopecias.
- Dermoscopic Analysis of Patients with and without Poor Prognostic Indicators in Alopecia Areata – A Comparative Study In 85 patients, yellow dots, black dots, broken hairs and coudability hairs signalled poor-prognosis alopecia areata, while vellus hairs indicated a favorable outcome.
- “Factors Influencing Patient Satisfaction in Frontal Hairline Correction with Hair Transplantation: A Multicenter Retrospective Study” In 736 hairline-transplant patients, satisfaction varied by sex and was predicted by age, hair direction, selfie interest, and cost-to-income ratio.
- Multiomics Analysis of the Response to Ritlecitinib in Alopecia Areata Subtypes and Correlation With Efficacy A post-hoc trial analysis found ritlecitinib normalized immune gene expression in alopecia areata scalp, and these molecular shifts correlated with subsequent hair regrowth.
- Misdiagnoses of Hair and Scalp Disorders in Adult Patients With Skin of Color examines misdiagnoses of hair and scalp disorders in adult patients with skin of color.
- Regenerative Hair Pigmentation via Skin Organoids: Adaptive Patterning Mediated by Collagen VI and Semaphorin 3C In skin organoids, collagen VI and semaphorin 3C signaling guide melanocytes into their follicle niche to restore hair pigmentation.
- FR- Mesoterapia con bicalutamida: una nueva alternativa para la alopecia androgenética Bicalutamide mesotherapy is presented as a new alternative for androgenetic alopecia.
- Immune‐Mediated Disorders in Patients With Alopecia Areata: Systematic Review and Meta‐Analysis A meta-analysis links alopecia areata to higher odds of vitiligo, lupus, autoimmune thyroiditis, atopic dermatitis and IBD, supporting routine comorbidity screening.
- Integrated single-cell chromatin and transcriptomic analyses of peripheral immune cells in patients with alopecia areata Single-cell mapping of blood immune cells in alopecia areata reveals severity-linked inflammatory and epigenetic changes, identifying candidate pathways for future therapies.
- CD133 defines hair-inductive cells in the dermal papilla In mouse skin-graft assays, CD133-positive dermal papilla cell spheroids grew more hairs than CD133-negative ones.
- Causes and therapeutic limitations of clinical alopecia and the advent of human pluripotent stem cell follicular transplantation A review concluding that current hair-loss treatments and transplants are limited and that iPSC-derived follicles could one day expand graft supply.
- Vinegar-Processed Black Soybean Promotes Hair Growth and Prevents Alopecia via Wnt/β-Catenin Pathway. In mice, vinegar-processed black soybean dose-dependently promoted hair growth and reduced cyclophosphamide-induced alopecia via Wnt/β-catenin signaling.
- The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study
- Adenosine as an Active Ingredient in Topical Preparations Against Hair Loss: A Systematic Review and Meta-Analysis of Published Clinical Trials
- Germination Enhances Phytochemical Profiles of Perilla Seeds and Promotes Hair Growth via 5α-Reductase Inhibition and Growth Factor Pathways