July 202235
Microneedling plus 5% minoxidil beat minoxidil with spironolactone or alone for female pattern hair loss; that combination also improved hair appearance in androgenetic alopecia. Injected dutasteride mesotherapy improved hair loss with mild self-limited side effects, mostly pain, in a retrospective series. Serum alarin was elevated in men with androgenetic alopecia and correlated with baldness severity. Pumpkin seed oil niosomes inhibited 5α-reductase in cells and cut shedding in vivo. Platelet-rich plasma showed no significant difference from triamcinolone injections for alopecia areata. Post-COVID hair loss was found to be mainly telogen effluvium resolving within months.
- Efficacy and Safety of 5% Minoxidil Alone, Minoxidil Plus Oral Spironolactone, and Minoxidil Plus Microneedling on Female Pattern Hair Loss: A Prospective, Single-Center, Parallel-Group, Evaluator Blinded, Randomized Trial In a 120-woman randomized trial, adding microneedling to 5% minoxidil beat minoxidil plus spironolactone or minoxidil alone for female pattern hair loss.
- Mesotherapy With Dutasteride for Androgenetic Alopecia: A Retrospective Study in Real Clinical Practice. In 541 patients, injected dutasteride mesotherapy improved hair loss with only mild self-limited side effects, mostly pain; no sexual adverse events reported in this retrospective series.
- Platelet-Rich Plasma in Alopecia Areata—A Steroid-Free Treatment Modality: A Systematic Review and Meta-Analysis of Randomized Clinical Trials A meta-analysis of four RCTs found no significant difference between PRP and triamcinolone injections for alopecia areata; better trials are needed.
- Pumpkin Seed Oil-Loaded Niosomes for Topical Application: 5α-Reductase Inhibitory, Anti-Inflammatory, and In Vivo Anti-Hair Loss Effects Pumpkin seed oil niosomes inhibited 5α-reductase in cells and cut hair shedding by 44% in an 8-week in vivo test.
- Effects of microneedling with 5% minoxidil topical solution combination therapy in treatment of androgenetic alopecia In 18 AGA patients, six weekly microneedling sessions plus 5% minoxidil improved hair appearance, with 83% satisfaction.
- Insights into male androgenetic alopecia using comparative transcriptome profiling: hypoxia-inducible factor-1 and Wnt/β-catenin signalling pathways Transcriptome profiling of balding follicles implicates HIF-1 and Wnt pathway genes as potential therapeutic targets in male AGA.
- Telemedical care of men with androgenetic alopecia demonstrates improved access to care and patient benefit telemedical care of men with androgenetic alopecia improved access to care and patient benefit.
- Application of Cell-Derived Extracellular Vesicles and Engineered Nanovesicles for Hair Growth: From Mechanisms to Therapeutics A review summarizes how cell-derived and engineered nanovesicles may deliver regenerative cargo to stimulate hair growth.
- A Drug‐Free, Hair Follicle Cycling Regulatable, Separable, Antibacterial Microneedle Patch for Hair Regeneration Therapy In mice, a drug-free microneedle patch releasing exosomes and lactate promoted hair regeneration more than topical minoxidil within seven days.
- Characteristics of hair loss after COVID‐19: A systematic scoping review A scoping review finds post-COVID hair loss is mainly telogen effluvium, starting around 2 months, with 95% resolution by ~5 months.
- Promotion of Hair Regrowth by Transdermal Dissolvable Microneedles Loaded with Rapamycin and Epigallocatechin Gallate Nanoparticles In mice, dissolvable microneedles delivering rapamycin plus EGCG nanoparticles promoted visible hair regrowth within 7 days with little inflammation.
- Androgenetic Alopecia and Metabolic Syndrome: Is Alarin a Missing Link? In 50 men with AGA, serum alarin was elevated and correlated with baldness severity; 82% met metabolic syndrome criteria.
- Healthcare Utilization and Costs Among US Adolescents With Alopecia Areata US adolescents with alopecia areata had several-fold higher healthcare visits and costs than matched controls, a claims database analysis found.
- Ficoll density gradient sedimentation isolation of pelage hair follicle mesenchymal stem cells from adult mouse back skin: a novel method for hair follicle mesenchymal stem cells isolation A density-gradient method efficiently isolated mouse follicle stem cells that promoted hair growth via secreted exosomes.
- Oxidative stress and antioxidant markers in patients with alopecia areata: A comparative cross-sectional study Patients with alopecia areata showed higher oxidative stress markers and lower antioxidant enzymes than healthy controls in a cross-sectional study.
- Application of extracellular vesicles from mesenchymal stem cells promotes hair growth by regulating human dermal cells and follicles Stem-cell extracellular vesicles carrying Wnt3a promoted human follicle cell growth and hair shaft elongation in culture.
- Frontal fibrosing alopecia: A review of disease pathogenesis A review of frontal fibrosing alopecia pathogenesis covering immune privilege collapse, genetics and possible triggers.
- Hair Follicle Morphogenesis During Embryogenesis, Neogenesis, and Organogenesis A review of how hair follicles form and are maintained during development, neogenesis and organogenesis.
- Vitamin A in Skin and Hair: An Update A review covers how retinoids regulate hair follicle stem cells, the hair cycle, and skin pigmentation.
- Inflammatory complications after hair transplantation: Report of 10 cases In 10 patients, hair transplantation triggered inflammatory scarring conditions, mostly lichen planopilaris; authors urge preoperative dermoscopy screening.
- Disrupted citric acid metabolism inhibits hair growth In mice, excess citric acid suppressed hair growth via inflammation and apoptosis, reversible by citrate synthase knockdown.
- Cell Population Dynamics in Wound-Induced Hair Follicle Neogenesis Model Flow cytometry maps cell populations over time in the mouse wound-induced hair follicle neogenesis model, guiding future studies.
- Epidemiological Trends in Alopecia Areata at the Global, Regional, and National Levels Global alopecia areata case numbers rose from 1990 to 2019 while age-standardized incidence slightly declined, a Global Burden of Disease analysis found.
- Using qualitative methods to establish the clinically meaningful threshold for treatment success in alopecia areata Interviews with clinicians and patients set 80% scalp hair (SALT ≤20) as a meaningful treatment success threshold in alopecia areata.
- Evaluating the combined efficacy of oral isotretinoin and topical tacrolimus versus oral finasteride and topical tacrolimus in frontal fibrosing alopecia—A randomized controlled trial In a 31-patient trial, isotretinoin plus tacrolimus outperformed finasteride plus tacrolimus for frontal fibrosing alopecia.
- Comparative study between topical methotrexate 1% gel and minoxidil 5% gel in the treatment of localized alopecia areata In a 50-patient trial, topical methotrexate 1% gel performed comparably to minoxidil 5% gel for localized alopecia areata.
- Menopause, skin and common dermatoses. Part 1: hair disorders A review linking menopausal hormone changes to female pattern hair loss and frontal fibrosing alopecia, noting therapy targets remain unclear.
- Unrevealing the Potential of Sansevieria trifasciata Prain Fraction for the Treatment of Androgenetic Alopecia by Inhibiting Androgen Receptors Based on LC-MS/MS Analysis, and In-Silico Studies In silico, four snake plant compounds docked to androgen receptor better than minoxidil; no animal or human testing.
- Evaluation of efficacy of follicular unit extraction versus follicular unit extraction with platelet rich plasma in treatment of cicatricial alopecia In 20 scarring alopecia patients, adding PRP to follicular unit extraction did not improve graft survival over FUE alone.
- Efficacy of intramuscular injections of biotin and dexpanthenol in the treatment of diffuse hair loss: A randomized, double‐blind controlled study comparing two brands In a 50-patient randomized trial, six weekly biotin and dexpanthenol injections of either brand reduced hair fall and increased density in diffuse hair loss.
- Regulation and dysregulation of hair regeneration: aiming for clinical application A review of stem-cell and environmental regulation of hair regeneration and its dysregulation in hair disorders.
- Exploring the Mechanisms and Molecular Targets of Taohong Siwu Decoction for the Treatment of Androgenetic Alopecia Based on Network Analysis and Molecular Docking In silico analysis suggests a traditional Chinese decoction may act on AGA via anti-inflammatory, antioxidant pathways; no human testing.
- Coconut, Castor, and Argan Oil for Hair in Skin of Color Patients: A Systematic Review. A systematic review found coconut oil helps brittle hair and infestation, castor oil only luster, and argan oil has no proven hair benefit.
- Self-assembled complete hair follicle organoids by coculture of neonatal mouse epidermal cells and dermal cells in Matrigel Mouse epidermal and dermal cells self-assembled in Matrigel into hair follicle organoids mimicking native follicle compartments.
- Characteristics of Patients with Hair Loss after Isotretinoin Treatment In a retrospective comparison, isotretinoin users who developed hair loss were older and had higher cumulative doses and longer treatment duration.