August 202234
Topical spironolactone plus minoxidil reduced vellus hair and dermoscopic signs of pattern hair loss. A comparison of oral agents ranked dutasteride most effective, then finasteride, then minoxidil. A review of nonsurgical treatments covered minoxidil, finasteride, laser, and platelet-rich plasma. PRP monotherapy protocols worked better with more sessions and chemical activation. Topical cetirizine beat placebo but was less effective than minoxidil. Microneedling alone or with topicals was reported effective for pattern hair loss. ALRV5XR in clinical trials increased terminal hair density in women and men. Hair transplantation improved quality-of-life utility scores. In mice, conditioned-media microneedles regrew hair faster than minoxidil.
- Dermoscopic evaluation of the efficacy of combination of topical spironolactone 5% and minoxidil 5% solutions in the treatment of androgenetic alopecia: A cross sectional‐comparative study In 120 AGA patients, topical 5% spironolactone plus 5% minoxidil reduced vellus hair and dermoscopic signs; authors say combining both may boost efficacy safely.
- Comparison of oral minoxidil, finasteride, and dutasteride for treating androgenetic alopecia A review ranks probable oral efficacy for AGA as dutasteride 0.5 mg > finasteride 5 mg > minoxidil 5 mg > finasteride 1 mg > minoxidil 0.25 mg, with differing side-effect profiles.
- Noninvasive Hair Rejuvenation A review covers the three FDA-approved nonsurgical androgenetic alopecia treatments (minoxidil, finasteride, low-level laser) and notes platelet-rich plasma shows promise.
- Platelet-Rich Plasma Monotherapies for Androgenetic Alopecia: A Network Meta-Analysis and Meta-Regression Study A network meta-analysis of 25 trials finds PRP works better with more sessions at shorter intervals, chemical activation, and double centrifugation.
- The pros and cons of follicular unit extraction (FUE) versus elliptical donor harvesting (FUT) A review outlines pros and cons of FUE versus strip harvesting to guide hair transplant technique choice.
- An overview of JAK/STAT pathways and JAK inhibition in alopecia areata A review explains JAK/STAT signaling in alopecia areata and how JAK inhibitors, including FDA-approved baricitinib, promote regrowth.
- The efficacy and safety of JAK inhibitors for alopecia areata: A systematic review and meta-analysis of prospective studies A meta-analysis of 14 studies found oral JAK inhibitors effective and well tolerated in alopecia areata, but 54% relapsed after stopping, so continued treatment may be needed.
- Health Utility Measures Among Patients with Androgenetic Alopecia After Hair Transplant A cohort study of 31 patients finds hair transplantation improves quality-of-life utility scores, exceeding minimal clinically important difference in 45% of patients.
- Conditioned media-integrated microneedles for hair regeneration through perifollicular angiogenesis In AGA mice, dissolvable microneedles delivering stem-cell conditioned media boosted perifollicular blood vessels and regrew hair faster than minoxidil.
- Shared Decision-Making, Therapeutic Choice, and Decisional Regret in Patients With Alopecia Areata In a 1074-patient alopecia areata survey, shared decision-making reduced decisional regret; JAK inhibitors had the lowest regret, anthralin and minoxidil the highest.
- Topical cetirizine for treating androgenetic alopecia: A systematic review A systematic review of three trials finds 1% topical cetirizine beats placebo for AGA but appears less effective than minoxidil for hair density.
- Hair Loss and Telogen Effluvium Related to COVID-19: The Potential Implication of Adipose-Derived Mesenchymal Stem Cells and Platelet-Rich Plasma as Regenerative Strategies A review finds COVID-19 raises incidence of pattern hair loss and telogen effluvium, with only one small PRP study published so far.
- Glycyrrhizin micellar nanocarriers for topical delivery of baicalin to the hair follicles: A targeted approach tailored for alopecia treatment Glycyrrhizin micelles delivered baicalin through hair follicles, boosted dermal papilla cell growth and activated Wnt/β-catenin, acting synergistically against alopecia in lab models.
- Staphylococcus epidermidis Cicaria, a Novel Strain Derived from the Human Microbiome, and Its Efficacy as a Treatment for Hair Loss Ex vivo, adenosine and biotin from a scalp bacterium lengthened human hair follicles and prolonged the growth phase.
- A Comprehensive Review of Microneedling as a Potential Treatment Option for Androgenetic Alopecia A review of 29 studies finds microneedling appears safe and effective for androgenetic alopecia, alone or with topicals, but larger trials are needed.
- Sex differences in clinical trials of ALRV5XR treatment of androgenetic alopecia and telogen effluvium In two 24-week placebo-controlled trials, ALRV5XR increased terminal hair density (30.1 hairs/cm2 in women, 21.0 in men) with no adverse events reported.
- Ablative 2940 nm Er: YAG fractional laser for male androgenetic alopecia A study tests an ablative 2940 nm Er:YAG fractional laser for male androgenetic alopecia.
- Intradermal Botulinum Toxin A Injection for Scalp Sebum Secretion Regulation: A Multicenter, Randomized, Double-Blinded, Placebo-Controlled, Prospective Study in Chinese Subjects In a 49-patient randomized trial, one intradermal botulinum toxin A session cut scalp sebum for about three months versus saline.
- Hair Growth Regulation by Fibroblast Growth Factor 12 (FGF12) In mice, FGF12 promotes hair growth by driving telogen-to-anagen transition; knockdown delayed regrowth and overexpression accelerated it.
- DNA Methylation Mediates lncRNA2919 Regulation of Hair Follicle Regeneration In rabbits, lncRNA2919 negatively regulates hair follicle regeneration, with DNA methylation suppressing its expression during the hair cycle.
- Identification of Hair Growth Promoting Components in the Kernels of Prunus mira Koehne and Their Mechanism of Action In mice, vitamin E, beta-sitosterol and linoleic acid from Prunus mira kernels promoted hair growth, likely via Wnt/β-catenin.
- JAM-A facilitates hair follicle regeneration in alopecia areata through functioning as ceRNA to protect VCAN expression in dermal papilla cells Lab work shows JAM-A 3' UTR acts as a competing endogenous RNA protecting VCAN to support dermal papilla cell function in alopecia areata.
- Depth control in follicular unit excision: A new classification from a detailed analysis of 30 patients undergoing FUE technique for hair restoration Analysis of 30 FUE patients proposes a three-grade depth-control classification for atraumatic graft extraction across donor zones.
- Common Causes of Hair Loss A JAMA article reviews common causes of hair loss.
- Intermediate Hair Follicles from Patients with Female Pattern Hair Loss Are Associated with Nutrient Insufficiency and a Quiescent Metabolic Phenotype Lab analysis of female pattern hair loss follicles shows miniaturized hairs have nutrient insufficiency and quiescent metabolism but can still absorb nutrients.
- Systemic minoxidil for hair disorders in pediatric patients: a safety and tolerability review In 63 children aged 0-12, low-dose oral and sublingual minoxidil for hair disorders were generally well tolerated, with mild hypertrichosis most common.
- The Emergent Power of Human Cellular vs Mouse Models in Translational Hair Research A review argues mouse hair follicle differences limit translation and advocates human cell bioengineered models for hair research.
- Pericardial, pleural effusion and anasarca: A rare complication of low-dose oral minoxidil for hair loss A case report describes pericardial and pleural effusion with anasarca as a rare complication of low-dose oral minoxidil used for hair loss.
- Natural results of scalp micropigmentation: A review A review outlines scalp micropigmentation techniques and tips for achieving natural-looking camouflage of scars and alopecia.
- UV and visible light exposure to hair leads to widespread changes in the hair lipidome Lab lipidomics showed UV and visible light exposure broadly depleted lipids in hair, consistent with oxidation damage.
- The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial In 64 women with PCOS, 10 weeks of magnesium improved quality of life but had no significant effect on alopecia, acne, or bleeding.
- Finasteride-loaded nano-lipidic carriers for follicular drug delivery: preformulation screening and Box-Behnken experimental design for optimization of variables In a lab study, finasteride-loaded nanostructured lipid carriers were optimized for topical follicular delivery, showing 84% entrapment and sustained 24-hour release.
- Marginal Traction Alopecia: Hair Care Practices, Severity Score and Trichoscopic Features in Lagos, Nigeria.
- Effective treatment of alopecia universalis with oral upadacitinib