February 202236
A meta-analysis found platelet-rich plasma therapy significantly increased hair density, with more treatments and younger age improving results. An RCT found topical flutamide plus minoxidil outperformed minoxidil alone for hair density and thickness. A real-world study found low-level laser therapy achieved roughly 80% clinical effectiveness, best with over a year of use. A network meta-analysis ranked dutasteride 0.5 mg highest for hair count, ahead of oral minoxidil and finasteride. A trial found watercress extract lotion increased hair thickness and density. A study found female pattern hair loss in 52% of postmenopausal women. A case-control study linked early-onset female pattern hair loss to androgen features. A trial found intralesional vitamin D3 significantly improved localized alopecia areata versus saline.
- Effectiveness of Platelet-Rich Plasma Therapy in Androgenic Alopecia—A Meta-Analysis A meta-analysis finds PRP significantly increases hair density, with more treatments per month and younger age giving better results.
- Serious Adverse effects From Compounding Errors With Low-Dose Oral Minoxidil for Alopecia Treatment Compounding pharmacy errors with low-dose oral minoxidil for alopecia caused serious adverse effects, highlighting risks of non-standard formulations.
- Comparison between “5% minoxidil plus 2% flutamide” solution vs. “5% minoxidil” solution in the treatment of androgenetic alopecia A 40-patient RCT finds topical 2% flutamide plus 5% minoxidil beats minoxidil alone for hair density and thickness.
- Efficacy assessment for low-level laser therapy in the treatment of androgenetic alopecia: a real-world study on 1383 patients In 1383 real-world users, low-level laser helmets gave ~80% clinical effectiveness, best with over a year of use, in men with scalp symptoms.
- Relative Efficacy of Minoxidil and the 5-α Reductase Inhibitors in Androgenetic Alopecia Treatment of Male Patients A network meta-analysis ranks dutasteride 0.5 mg highest for hair count at 24 weeks, with oral minoxidil 5 mg and finasteride also outperforming topical minoxidil.
- Early onset female pattern hair loss: a case–control study for analyzing clinical features and genetic variants A case-control study links early-onset female pattern hair loss to androgen features and variants near PPARGC1A and other genes.
- Thymic stromal lymphopoietin controls hair growth In mice, wound-induced TSLP promoted hair growth via follicle stem cell TSLPR signaling; blocking it inhibited regrowth.
- Alopecia in patients with COVID-19: A systematic review and meta-analysis A meta-analysis finds telogen effluvium usually newly triggered by COVID-19, while AGA may mark risk of severe disease.
- Prevalence of female pattern hair loss in postmenopausal women: a cross-sectional study A study finds female pattern hair loss in 52% of postmenopausal women, linked to higher body mass index.
- Intralesional vitamin D3 in treatment of alopecia areata: A randomized controlled clinical trial In a 60-patient trial, intralesional vitamin D3 injections significantly improved localized alopecia areata versus saline, with negligible transient side effects.
- Whole exome sequencing in Alopecia Areata identifies rare variants in KRT82 Exome sequencing in 849 patients identified rare damaging KRT82 variants as an alopecia areata risk factor linked to increased CD8 infiltrates.
- Safflower oil body nanoparticles deliver hFGF10 to hair follicles and reduce microinflammation to accelerate hair regeneration in androgenetic alopecia In AGA mice, safflower oil nanoparticles delivering hFGF10 accelerated hair regrowth by reducing follicle microinflammation.
- Effects of watercress extract fraction on R‐spondin 1‐mediated growth of human hair A six-month trial finds 2% watercress extract lotion increased hair thickness and density, via boosting RSPO1 and suppressing DKK1.
- Evaluating the Therapeutic Potential of Ritlecitinib for the Treatment of Alopecia Areata A review finds ritlecitinib, a JAK3/TEC inhibitor, induced significant hair regrowth in alopecia areata trials, with more long-term data needed.
- Effects of a Combination of Arginine Silicate Inositol Complex and a Novel Form of Biotin on Hair and Nail Growth in a Rodent Model In rats, arginine silicate inositol plus magnesium biotinate increased hair density and growth-factor signaling versus control.
- Different levels of EGF, VEGF, IL‐6, MCP‐1, MCP‐3, IP‐10, Eotaxin and MIP‐1α in the adipose‐derived stem cell secretome in androgenetic alopecia A study of six men finds distinct signaling protein levels in stem cell secretome from balding versus non-balding scalp.
- Isolation and identification of hair growth potential fraction from active plant extract of Blumea eriantha DC grown in Western Ghat of India: In silico study Blumea eriantha extract and its constituent dimethyl sulfone showed hair growth promotion in vitro and in vivo, docked against minoxidil targets.
- Serum nuclear factor E‐2‐related factor 2 in female pattern hair loss A case-control study finds lower antioxidant NRF2 and higher oxidative stress in women with female pattern hair loss.
- Nanomaterials in hair care and treatment A review finds nanomaterial delivery systems could improve stability, targeting and safety of hair-care active ingredients.
- Minoxidil-loaded hyaluronic acid dissolving microneedles to alleviate hair loss in an alopecia animal model In mice, hyaluronic acid microneedles with one-tenth the minoxidil dose grew hair better than topical minoxidil.
- Regulation of Cytokines and Dihydrotestosterone Production in Human Hair Follicle Papilla Cells by Supercritical Extraction-Residues Extract of Ulmus davidiana In human dermal papilla cells, an Ulmus davidiana extract reduced dihydrotestosterone production and modulated growth-related cytokines.
- A network pharmacology-based approach to explore mechanism of action of medicinal herbs for alopecia treatment A network pharmacology analysis proposed target genes and pathways by which 20 medicinal herbs might treat alopecia.
- MicroRNA-149-Mediated MAPK1/ERK2 Suppression Attenuates Hair Follicle Stem Cell Differentiation In cells and mice, miR-149 suppressed hair follicle stem cell proliferation and differentiation by targeting MAPK1/ERK2.
- Epidemiology and disease burden of androgenetic alopecia in college freshmen in China: A population-based study A survey of 9227 Chinese college freshmen finds AGA prevalence of 5.3 per 1000, associated with rosacea.
- Comprehensive Analysis of LncRNA AC010789.1 Delays Androgenic Alopecia Progression by Targeting MicroRNA-21 and the Wnt/β-Catenin Signaling Pathway in Hair Follicle Stem Cells A lab study shows lncRNA AC010789.1 overexpression boosts hair follicle stem cells via miR-21 and Wnt/beta-catenin pathways.
- The associated burden of mental health conditions in alopecia areata: a population‐based study in UK primary care* A UK population study finds people with alopecia areata have higher depression, anxiety, unemployment and time off work.
- Effects of exosome from adipose‐derived stem cell on hair loss: A retrospective analysis of 39 patients A retrospective series examined adipose stem cell exosome treatment for hair loss in 39 patients.
- Stimulatory Effects of Extracellular Vesicles Derived from Leuconostoc holzapfelii That Exists in Human Scalp on Hair Growth in Human Follicle Dermal Papilla Cells In cultured human dermal papilla cells, extracellular vesicles from a scalp bacterium promoted proliferation and hair-growth gene expression via Wnt/β-catenin signaling.
- Association between alopecia areata and COVID-19: A systematic review A review finds alopecia areata may follow COVID-19 infection by one to two months, mostly in case reports.
- Comparing the frequency of isotretinoin-induced hair loss at <0.5-mg/kg/d versus ≥0.5-mg/kg/d dosing in acne patients: A systematic review A systematic review found isotretinoin-related hair loss in 3.2% at lower doses versus 5.7% at higher doses, though inferential statistics were not possible and better studies are needed.
- Nanostructured lipid carriers loaded with an association of minoxidil and latanoprost for targeted topical therapy of alopecia A lab study shows lipid nanoparticles target a minoxidil-latanoprost combination into hair follicles and appear well tolerated.
- Integrated Transcriptomics and Metabolomics Analyses of Stress-Induced Murine Hair Follicle Growth Inhibition In stressed mice, metabolomics and transcriptomics revealed metabolic pathway disruptions underlying hair growth inhibition.
- Observations that suggest a contribution of altered dermal papilla mitochondrial function to androgenetic alopecia A lab study finds balding dermal papilla cells show mitochondrial dysfunction and oxidative stress, partly improved by antioxidants.
- Comparative study of the use of fractional CO 2 laser versus the use of liquid nitrogen cryotherapy in the treatment of alopecia areata in a sample of the Egyptian population In 80 alopecia areata patients, fractional CO2 laser outperformed liquid nitrogen cryotherapy, with no serious side effects.
- Exosomes Secreted from Adipose-Derived Stem Cells Are a Potential Treatment Agent for Immune-Mediated Alopecia In mice, adipose stem cell exosomes promoted hair regrowth via Wnt/beta-catenin activation and reduced TNF-alpha signaling.
- Bioactive Small Molecule Enhances Skin Burn Wound Healing and Hair Follicle Regeneration by Activating PI3K/AKT Signaling Pathway: A Preclinical Evaluation in Animal Model In mice with skin burns, shikonin ointment sped wound healing and hair follicle regeneration via PI3K/AKT signaling.