November 202237
Nutritional supplements for hair loss showed potential benefit across 30 studies. Photobiomodulation with pulsed electromagnetic fields increased hair density versus sham in a randomized trial. Electric microneedling added to standard therapy produced response in all patients, with 19% marked improvement. Topical quercetin stimulated resting follicles in mice by activating HIF-1α-driven angiogenesis. An androgen-receptor siRNA promoted hair growth in mice and improved human follicle measures ex vivo. Cell therapies including dermal papilla cells were found effective for regeneration. Genetic models from UK Biobank predicted severe male pattern baldness with AUCs near 0.73. Minoxidil nanocarriers improved follicle delivery in reviewed formulations, though clinical data are lacking. Baricitinib in severe alopecia areata showed low serious-infection rates and no deaths.
- Evaluation of the Safety and Effectiveness of Nutritional Supplements for Treating Hair Loss A systematic review of 30 studies found potential benefit from supplements like Viviscal, Nutrafol, and pumpkin seed oil, with rare, mild adverse effects.
- The efficacy and safety of the combination of photobiomodulation therapy and pulsed electromagnetic field therapy on androgenetic alopecia In an 80-patient randomized trial, combined photobiomodulation and pulsed electromagnetic field therapy increased hair density versus sham over 24 weeks.
- Observation on the Efficacy of a Combined Treatment for Moderate and Severe Androgenetic Alopecia Incorporating Electric Microneedles In 83 patients, adding weekly electric microneedling to finasteride or spironolactone plus minoxidil produced response in all patients, with 19% marked improvement.
- Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration Topical quercetin stimulated resting hair follicles to grow in mice by activating HIF-1α-driven angiogenesis around follicles.
- Keratin-mediated hair growth and its underlying biological mechanism In mice, intradermal keratin injections promoted hair growth by driving dermal papilla cell condensation and hair germ formation.
- Integrated safety analysis of baricitinib in adults with severe alopecia areata from two randomized clinical trials Pooled trial data on 1303 patients with severe alopecia areata found baricitinib's safety profile consistent with known effects, with low rates of serious infections, one cardiovascular event, and no deaths.
- Efficacy of Asymmetric siRNA Targeting Androgen Receptors for the Treatment of Androgenetic Alopecia An androgen-receptor-targeting siRNA promoted hair growth in DHT-treated mice and improved human hair follicle measures ex vivo.
- Effective and economical cell therapy for hair regeneration A review found adipose-derived stem cells, dermal sheath cup cells and dermal papilla cells promising for hair regeneration, with off-the-shelf dermal papilla therapy highlighted.
- Genetic prediction of male pattern baldness based on large independent datasets Genetic models built from 187,435 UK Biobank subjects predicted male pattern baldness with AUCs around 0.73 for severe hair loss.
- A lipid–polymer hybrid nanoparticle (LPN)-loaded dissolving microneedle patch for promoting hair regrowth by transdermal miR-218 delivery In mice, a dissolving microneedle patch delivering miR-218 via nanoparticles promoted hair regrowth better than topical application.
- Enhancement of hair growth through stimulation of hair follicle stem cells by prostaglandin E2 collagen matrix In a mouse hair-loss model, a PGE2-collagen matrix injection boosted growing follicles and activated hair follicle stem cells.
- Scalable and high-throughput production of an injectable platelet-rich plasma (PRP)/cell-laden microcarrier/hydrogel composite system for hair follicle tissue engineering Injectable PRP-loaded hydrogel microcarriers seeded with dermal papilla cells generated about 35 hair follicles per site in mice.
- Alopecia Areata: Case report and review of pathophysiology and treatment with Jak inhibitors A review with case report describes how JAK inhibitors like tofacitinib can effectively treat alopecia areata, with several agents in phase 2–3 trials.
- Exploiting Recent Trends in the Treatment of Androgenic Alopecia through Topical Nanocarriers of Minoxidil A review of minoxidil nanocarrier formulations shows they improve follicle delivery and reduce irritation, but clinical data are lacking.
- Wnt/β-catenin signaling activator restores hair regeneration suppressed by diabetes mellitus In diabetic mice, the Wnt/β-catenin activator KY19382 restored delayed hair regrowth and follicle neogenesis suppressed by diabetes.
- Efficacy of Jessener solution versus intralesional steroid in treatment of alopecia areata In 40 patients, Jessner solution matched intralesional steroids for patchy alopecia areata response, both beating saline, over three sessions.
- Bio-Pulsed Stimulation Effectively Improves the Production of Avian Mesenchymal Stem Cell-Derived Extracellular Vesicles That Enhance the Bioactivity of Skin Fibroblasts and Hair Follicle Cells In lab cell cultures, bio-pulsed avian stem cell exosomes enhanced proliferation and gene activity in skin and dermal papilla cells.
- Anxiety, depression, and quality of life in children and adults with alopecia areata: A systematic review and meta-analysis A meta-analysis found people with alopecia areata have more anxiety and depression symptoms and moderately impaired quality of life.
- A narrative review on subcutaneous injection components used for alopecia A review identified eight substances used via subcutaneous injection for alopecia in 19 articles, noting evidence gaps.
- Cells, growth factors and biomaterials used in tissue engineering for hair follicles regeneration A review of cells, growth factors, and biomaterials used in tissue engineering for hair follicle regeneration.
- Lactobacillus paracasei HY7015 and Lycopus lucidus Turcz. Extract Promotes Human Dermal Papilla Cell Cytoprotective Effect and Hair Regrowth Rate in C57BL/6 Mice In mice, oral Lactobacillus HY7015 and Lycopus extract promoted hair regrowth and raised VEGF and IGF-1 growth factors.
- Platelet-rich plasma in alopecia areata and primary cicatricial alopecias: A systematic review A systematic review of 32 studies found PRP promising for alopecia areata and scarring alopecias, but evidence quality was too low to recommend it.
- The efficacy of LED microneedle patch on hair growth in mice In mice, a green-light LED microneedle patch sped the shift to the hair growth phase and increased follicle numbers.
- Assessment of the anti‐hair loss potential of <i>Camellia japonica</i> fruit shell extract in vitro In cell cultures, Camellia japonica fruit shell extract boosted dermal papilla cell growth and suppressed 5α-reductase activity and DHT effects.
- Beyond the Hot Comb: Updates in Epidemiology, Pathogenesis, and Treatment of Central Centrifugal Cicatricial Alopecia from 2011 to 2021 A review updates CCCA management: steroids and tetracyclines remain mainstays, with transplantation for refractory cases and emerging PRP options.
- Aging of hair follicle stem cells and their niches A review of how aging of hair follicle stem cells and their niches drives age-related hair loss and possible ways to reverse it.
- Effects of Natural Polyphenols on Skin and Hair Health: A Review A review of natural polyphenols describes antioxidant and anti-inflammatory mechanisms with potential benefits for skin diseases and hair loss in vitro and in vivo.
- The Molecular Mechanism of Natural Products Activating Wnt/β-Catenin Signaling Pathway for Improving Hair Loss A review of natural products that activate Wnt/β-catenin signaling for hair growth, discussing mechanisms and cosmeceutical potential.
- A community-oriented survey on the association between androgenetic alopecia and metabolic syndrome in Chinese people A Chinese survey of 3,703 people found no direct association between androgenetic alopecia and metabolic syndrome, though systolic blood pressure was higher.
- [Translated article] Trichoscopy in Alopecia Areata A review of trichoscopy in alopecia areata lists yellow dots, black dots and exclamation-mark hairs as key findings; yellow dots signal chronic disease and poor response.
- Biomaterials for Treatment of Baldness A review of nanoparticle and biomaterial drug-delivery approaches for treating androgenetic alopecia.
- Microenvironmental reprogramming of human dermal papilla cells for hair follicle tissue engineering A biomimetic 3-D co-culture system restored hair-inductive properties in human dermal papilla cell aggregates via Wnt activation and BMP inhibition.
- Bioengineering of Hair Follicle-like Structure for Validation of Hair Growth Promoting Compounds An immortalized-cell hair-follicle-like structure responded to minoxidil, tofacitinib, and ascorbic acid, offering a screening model for hair-growth compounds.
- Prevalence, comorbidities, and treatment patterns of Japanese patients with alopecia areata: A descriptive study using Japan medical data center claims database A Japanese claims study of 61,899 alopecia areata patients found rising prevalence and allergic diseases as the most common comorbidities.
- Investigation of hub genes and immune infiltration in androgenetic alopecia using bioinformatics analysis Bioinformatics analysis identified four hub genes (COL1A2, PCOLCE, ITGAX, LOX) linked to immune infiltration in androgenetic alopecia.
- Translation into Spanish Language (México), Transcultural Adaptation, and Validation of the Quality of Life Questionnaire in Female Pattern Hair Loss (WAA-QoL-Sp) A Spanish-language version of the female pattern hair loss quality-of-life questionnaire was validated in 453 women.
- Hair aging and hair disorders in elderly patients A review of hair aging and common hair disorders in patients over 65, aimed at helping clinicians manage them.