March 202232
VigiBase data on finasteride in young men found a disproportionate signal of sexual dysfunction reports. Low-dose oral minoxidil was reported to improve hair in 52% of patients and stabilize it in 43%, outperforming untreated controls. Topical finasteride was found comparable to oral, with side effects mostly local scalp irritation. Oral nutraceuticals were concluded to promote modest growth as adjuncts to standard treatments. Mesotherapy for pattern hair loss was judged modestly effective, though evidence remains limited. Smoking in androgenetic alopecia was found significantly associated, while quitting benefit was unproven. Oral baricitinib for severe alopecia areata produced significantly more scalp regrowth than placebo. Dexamethasone mini-pulses in alopecia areata achieved SALT-50 response in 51.8%, though higher doses meant more side effects.
- Disproportional signal of sexual dysfunction reports associated with finasteride use in young men with androgenetic alopecia: A pharmacovigilance analysis of VigiBase a VigiBase pharmacovigilance analysis found a disproportionate signal of sexual dysfunction reports with finasteride use in young men with androgenetic alopecia.
- Dutasteride intralesional microinjections in combination with oral minoxidil vs. oral minoxidil monotherapy in men with androgenetic alopecia: a retrospective analysis of 105 patients a retrospective analysis of 105 men compares dutasteride intralesional microinjections plus oral minoxidil against oral minoxidil alone for androgenetic alopecia.
- Oral minoxidil use in androgenetic alopecia and telogen effluvium In a 105-patient case-matched retrospective study, low-dose oral minoxidil for at least a year improved hair in 52% and stabilized it in 43%, significantly better than untreated controls.
- Topical finasteride for male and female pattern hair loss: Is it a safe and effective alternative? A review finds topical finasteride works comparably to oral, lowers scalp and plasma DHT, and its side effects are mostly local scalp irritation rather than systemic.
- Nutraceuticals for Androgenetic Alopecia. A review concludes oral nutraceuticals promote modest hair growth in men and women with androgenetic alopecia and may serve as adjuncts to standard treatments.
- Two Phase 3 Trials of Baricitinib for Alopecia Areata In two phase 3 trials, oral baricitinib gave severe alopecia areata patients significantly more scalp regrowth than placebo at 36 weeks.
- Alopecia Areata and Dexamethasone Mini-Pulse Therapy, A Prospective Cohort: Real World Evidence and Factors Related to Successful Response In a prospective alopecia areata cohort, dexamethasone mini-pulses achieved SALT-50 response in 51.8% by 9 months; early onset and hypothyroidism predicted nonresponse, and higher doses meant more side effects.
- Treatment of Androgenetic Alopecia Using PRP to Target Dysregulated Mechanisms and Pathways A review analyzes 17 recent clinical trials of PRP for androgenetic alopecia, including comparisons and combinations with minoxidil and finasteride.
- Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition From Telogen to Anagen Phase In mice, colostrum-derived exosomes regrew dorsal hair comparably to minoxidil by activating Wnt/β-catenin signaling, without skin irritation.
- Current application of mesotherapy in pattern hair loss: A systematic review A systematic review of 12 studies found mesotherapy modestly effective for pattern hair loss with no significant side effects, but evidence is limited.
- Platelet Rich Plasma and Its Use in Hair Regrowth: A Review A review covers PRP's mechanisms, clinical efficacy and adverse events in hair regrowth without stating a conclusion.
- Role of smoking in androgenetic alopecia: A systematic review A systematic review found smoking is significantly associated with androgenetic alopecia, though evidence that quitting improves hair loss is lacking.
- The Relationship Between Patient-Reported Severity of Hair Loss and Health-Related Quality of Life and Treatment Patterns Among Patients with Alopecia Areata A 1327-person survey found alopecia areata burden varies non-linearly with severity, and those with complete scalp loss were least likely to be in treatment.
- TERT/BMI1-transgenic human dermal papilla cells enhance murine hair follicle formation in vivo Human dermal papilla cells engineered to overexpress TERT and BMI1 avoided senescence and induced hair follicle formation in a mouse chamber assay.
- 5-Bromo-3,4-dihydroxybenzaldehyde Promotes Hair Growth through Activation of Wnt/β-Catenin and Autophagy Pathways and Inhibition of TGF-β Pathways in Dermal Papilla Cells BDB promoted hair growth in rat follicles and dermal papilla cells via Wnt/β-catenin and autophagy activation and TGF-β inhibition.
- Anti-Hair Loss Effect of Adenosine Is Exerted by cAMP Mediated Wnt/β-Catenin Pathway Stimulation via Modulation of Gsk3β Activity in Cultured Human Dermal Papilla Cells In cultured human dermal papilla cells, adenosine promoted hair-growth signaling by stimulating the Wnt/β-catenin pathway via cAMP and GSK3β modulation.
- Relationship between hair shedding and systemic inflammation in COVID-19 pneumonia In 104 post-COVID-19 patients, telogen effluvium was far more common in women and linked to disease severity and inflammation rather than androgen status.
- Assessing the role of stressful life events in the induction and recurrence of alopecia areata: A case-control study A case-control study assesses whether stressful life events trigger or recur alopecia areata.
- Efficacy of a mixed preparation containing piperine, capsaicin and curcumin in the treatment of alopecia areata A piperine-capsaicin-curcumin topical matched but did not beat 5% minoxidil for alopecia areata in a 60-patient trial.
- The effects of centipedegrass extract on hair growth via promotion of anagen inductive activity Centipedegrass extract promoted anagen entry and hair growth in mice via β-catenin signaling.
- Association of androgenetic alopecia with a more severe form of COVID-19 infection In 208 hospitalized men, severe androgenetic alopecia (Gabrin sign) and hypertension were associated with worse COVID-19 outcomes.
- Generation and characterization of hair-bearing skin organoids from human pluripotent stem cells A protocol generates hair-bearing skin organoids with follicles and glands from human pluripotent stem cells over ~130 days.
- Fuzhuan Brick Tea Boosts Melanogenesis and Prevents Hair Graying through Reduction of Oxidative Stress via NRF2-HO-1 Signaling In cells and mice, a Fuzhuan brick tea fraction reduced oxidative stress, boosted melanogenesis and prevented hair greying.
- The effect of latanoprost 0.005% solution in the management of scalp alopecia areata, a randomized double‐blind placebo‐controlled trial In a 30-patient randomized trial, topical latanoprost 0.005% added to clobetasol increased hair density and regrowth in scalp alopecia areata versus placebo.
- 3D bioprinting of a gelatin-alginate hydrogel for tissue-engineered hair follicle regeneration A 3D-bioprinted gelatin-alginate scaffold regenerated oriented hair follicles when transplanted into wounds in nude mice.
- Is idiopathic hirsutism idiopathic? A review finds elevated 5α-reductase activity markers likely explain idiopathic hirsutism in women.
- The role of SARS‐CoV‐2 infection and its vaccines in various types of hair loss A review finds COVID-19 infection and vaccines can trigger telogen effluvium and alopecia areata, usually self-resolving with reassurance.
- Advancing Regenerative Cellular Therapies in Non-Scarring Alopecia A review of regenerative cellular therapies for non-scarring alopecia finds mesenchymal stem cell treatments can regrow hair but lack standardized preparation and dosing.
- Hair Growth-Promoting Activities of Glycosaminoglycans Extracted from the Tunics of Ascidian (Halocynthia roretzi) x
- Predictors of Vitamin D Insufficiency in Children and Adolescents With Alopecia Areata In children with alopecia areata, darker skin type, non-summer season and non-White race predicted vitamin D insufficiency.
- Exosomal miRNA-181a-5p from the cells of the hair follicle dermal papilla promotes the hair follicle growth and development via the Wnt/β-catenin signaling pathway Exosomal miR-181a-5p from dermal papilla cells promoted hair follicle growth via Wnt/β-catenin signaling in vitro.
- Root hair quantification is an accessible approach to phenotyping important functional traits