research Beyond Expectations: The Role of Keratin Intermediate Filament Proteins in Epidermal Integrity
Keratin proteins are crucial for healthy skin, but mutations can cause skin disorders with no effective treatments yet.
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research Replicative Stress, Stem Cells, and Aging
Maintaining DNA health in stem cells is key to preventing aging and tissue breakdown.
research Ectopic Expression of the Nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia
The nude gene causes skin cell overgrowth and improper development, leading to hair and urinary issues.
research Frontal Fibrosing Alopecia: Reflections and Hypotheses on Etiology and Pathogenesis
FFA's causes may include environmental triggers and genetic factors.
research Aberrant Activation of the Hedgehog Signaling Pathway in Malignant Hematological Neoplasms
Abnormal Hedgehog signaling in blood cancers may help tumors grow and resist chemotherapy, suggesting potential for targeted treatments.
research Non-Edg Family LPA Receptors: The Cutting Edge of LPA Research
New LPA receptors (LPA4, LPA5, LPA6) have diverse roles in the body.
research Physiological and Pharmacological Features of the Non-Saponin Components in Korean Red Ginseng
Korean Red Ginseng has beneficial components that help with stress, immunity, fatigue, memory, blood flow, and disease protection.
research Age-Induced Hair Greying: The Multiple Effects of Oxidative Stress
Hair greying is caused by oxidative stress damaging hair follicles and melanocytes.
research Dissecting the Microenvironment Around Biosynthetic Scaffolds in Murine Skin Wound Healing
Different scaffold patterns improve wound healing and immune response in mouse skin, with aligned patterns being particularly effective.
research The Modulatable Stem Cell Niche: Tissue Interactions During Hair and Feather Follicle Regeneration
The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.
research Primary Cicatricial Alopecia
The document concludes that early recognition and treatment of primary cicatricial alopecia is crucial to prevent permanent hair loss.
research Alisertib Is Active as Single Agent in Recurrent Atypical Teratoid Rhabdoid Tumors in Four Children
Alisertib was found to be an effective and tolerable treatment for children with recurrent brain tumors.
research Interventions for Nail Psoriasis
Some systemic treatments work for nail psoriasis but can have serious side effects.
research Noggin Overexpression Inhibits Eyelid Opening by Altering Epidermal Apoptosis and Differentiation
Noggin overexpression delays eyelid opening by affecting cell death and skin cell development.
research The Paradox of p53: What, How, and Why?
The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.
research Immune Deficiency-Related Enteropathy-Lymphocytopenia-Alopecia Syndrome Results from Tetratricopeptide Repeat Domain 7A Deficiency
A deficiency in the TTC7A gene causes immune problems, gut issues, and hair loss.
research The Population Dynamics of Cancer: A Darwinian Perspective
Cancer development is like natural selection, involving mutated cells and environmental factors.
research Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened
The topical inhibitor CUR61414 was not effective in treating basal cell carcinoma in human trials.
research Compartmentalized Organization: A Common and Required Feature of Stem Cell Niches?
Compartmentalized organization might be crucial for stem cells to effectively respond to growth or injury.
research Androgen Action in the Ovary
Androgens are important for normal ovarian function and estrogen production, but may not be the main cause of follicle death.
research Recent Advances in the Molecular Mechanisms Determining Tissue Sensitivity to Glucocorticoids: Novel Mutations, Circadian Rhythm, and Ligand-Induced Repression of the Human Glucocorticoid Receptor
New findings explain how genetic changes, body clocks, and certain molecules affect tissue response to stress hormones.
research Hormone Replacement Therapy for Women with Premature Ovarian Insufficiency: A Comprehensive Review
The review recommends hormone replacement therapy for women with premature ovarian insufficiency to manage symptoms and protect health, with specific approaches for different groups.
research Transcriptional Profiling in Alopecia Areata Defines Immune and Cell Cycle Control Related Genes Within Disease-Specific Signatures
The study found that immune responses disrupt hair growth cycles, causing hair loss in alopecia areata.
research The Role of Lymphocytes in the Development and Treatment of Alopecia Areata
Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.
research Keratin 79 Identifies a Novel Population of Migratory Epithelial Cells That Initiates Hair Canal Morphogenesis and Regeneration
Keratin 79 marks a new group of cells that are key for creating and repairing the hair follicle's structure.
research Ovarian Hypertension: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome is linked to higher risk of hypertension and heart disease.
research Apoptosis and Cutaneous Biology
Apoptosis is crucial for healthy skin and treating skin diseases.
research Influence of TRPV3 Mutation on Hair Growth Cycle in Mice
The TRPV3 gene mutation affects hair growth by keeping mice in the growth phase longer, which could help treat hair loss.
research Wnt Signaling and Aging-Related Heart Disorders
Wnt signaling may be linked to heart diseases in aging and could be a target for future treatments.
research Sex Hormone-Binding Globulin as an Early Biomarker and Therapeutic Target in Polycystic Ovary Syndrome
SHBG may be a useful early indicator and treatment target for PCOS.