Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study identified several compounds from traditional Chinese medicines that may inhibit prostaglandin D2 synthase, potentially providing promising candidates for treating androgenic alopecia with minimal adverse skin reactions.

This study found that Ashwagandha-derived nanovesicles increased cell proliferation, angiogenesis, and growth factor expression in vitro, suggesting they may have potential as a plant-based alternative or complement to current therapies for hair and skin conditions.

This review discusses the bioactive compounds and biological activities of Polygonum multiflorum Thunb. and highlights concerns about its hepatotoxicity, but reports no new clinical results.

This study found that extracts from Terminalia bellirica enhanced dermal papilla cell viability, inhibited androgen-related pathways, and stimulated hair regrowth in a mouse model, suggesting potential for treating androgenetic alopecia through multi-target mechanisms.

This review identifies 1859 plant and fungal species from the Pantanal and highlights patents, mainly from South Korea, focused on extracts with antitumoral, anti-inflammatory, and cosmetic applications, but reports no new clinical results.

This review examines natural bioactive compounds for their potential to alleviate androgenetic alopecia, emphasizing compounds like ginseng and curcumin, but reports no new experimental results.

This study reports promising preliminary trends in the safety and efficacy of a botanical drug candidate for pediatric alopecia areata, but conclusive results are not yet available.

This review highlights the therapeutic potential of medicinal plants, such as Eclipta alba and Ginkgo biloba, for managing alopecia through various molecular mechanisms, but stresses the need for further clinical trials to confirm their safety and efficacy as alternatives to synthetic treatments.

Mitoxantrone with a corticosteroid helps manage symptoms for some advanced prostate cancer patients but doesn't extend life.

This study found that Cyanidin-3-O-glucoside and Vitisin A were able to penetrate mouse skin and improve issues related to hair follicle miniaturization and apoptosis in androgenetic alopecia, suggesting these compounds as potential alternative treatments for hair loss.

In this study, topical applications of Agrimonia pilosa extract and agrimonolide demonstrated notable anti-inflammatory and wound healing benefits in animal models, significantly reducing inflammation and enhancing wound closure compared to controls. However, further research in humans is needed to confirm these preclinical findings.

In this animal study, the methanolic extract of Crataeva nurvala leaves was found to possess sedative and anxiolytic properties, potentially linked to GABAergic activity and certain neuroactive compounds.

This review examines recent advances in androgenetic alopecia treatment, highlighting how multifunctional plant extracts combined with nanotechnology could improve topical therapy efficacy by enhancing local drug bioavailability and targeting, addressing limitations of existing treatments.

This study found that white wax and its extract significantly promoted hair growth in a mouse model of androgenetic alopecia, outperforming finasteride by inhibiting 5α-reductase activity and enhancing cellular proliferation.

This study found that compounds from Ziziphus spina-christi roots exhibited promising antibacterial and antioxidant activities, supporting its traditional medicinal use.

This study found petroleum ether to be more effective than methanol at extracting β-sitosterol from Eclipta alba, with higher concentrations detected using HPTLC and HPLC methods. The extracted materials contained metals within safety limits.

This study found that ALRN-6924, a clinical-stage dual inhibitor, can selectively protect human scalp hair follicles from paclitaxel-induced toxicity and damage by inducing transient cell cycle arrest in healthy cells without affecting cancer cells, potentially reducing chemotherapy-induced alopecia.

In this animal study, agmatine exhibited a protective effect against seizures related to hormone fluctuations, with results suggesting that its anticonvulsant properties may involve interactions with central neurosteroids in female rats experiencing progesterone withdrawal.

This study identified several herbs, including Ganoderma lucidum and Urtica dioica, that showed promising 5α-reductase inhibitory activity suggesting potential use in managing androgenic disorders.

This study found that Wera leaf extract, particularly its n-hexane fraction, significantly stimulated hair growth, suggesting its potential as an antialopecia treatment.

This study found that in Withdrawal Seizure-Prone mice, ethanol withdrawal decreased the sensitivity of GABA A receptors to GABAergic neurosteroids in certain areas of the brain.

This study evaluated the 5α-reductase inhibitory effects of several Ayurvedic herbs and found that Eclipta alba exhibited the highest activity, suggesting its potential for use in treatments for androgenic disorders like alopecia.

In this study, human cell models of hair follicles showed that araliadiol, a plant-derived polyacetylene compound, promotes hair growth through the p38/PPAR-γ signaling pathway, suggesting its potential as a new drug candidate for alopecia treatment.

This study found that bolandiol increased lean body mass and bone mineral density in castrate adult male rats, exhibiting tissue selectivity and acting through multiple receptor pathways with less potency compared to other androgens.

This study found that the alcohol extract of Vernonia anthelmintica may counteract stress-induced hair follicle growth inhibition in mice, potentially offering a new approach for treating stress-related hair loss.

This study found that polyacetylene compounds in Panax ginseng extracts may inhibit neurotrophin receptor binding, suggesting potential therapeutic benefits for alopecia and other hair growth disorders.

This study suggests that the methanol extract of Buxus wallichiana has promising antioxidant properties and may promote hair growth, with varying effectiveness depending on the dosage and application form.

This review explores the potential role of pregnane neurosteroids in modulating alcohol withdrawal symptoms, suggesting a therapeutic target for treating alcohol dependence, but reports no new clinical results.

This review focuses on the significant pharmacological properties and therapeutic potential of phytosterols, terpenoids, flavonoids, and phenolic compounds from the endangered plant Nardostachys Jatamansi, highlighting their diverse applications in disease prevention and treatment.