June 2026 in “International Journal of Drug Delivery Technology” This study developed EGCG-loaded nanohydrogels using ethyl cellulose and polyvinyl alcohol to enhance the stability and delivery of the hydrophilic drug in aloe vera gel, optimizing encapsulation efficiency and drug release properties.
19 citations
,
April 2017 in “Synapse” This study suggests that the neurosteroid allopregnanolone contributes to stress resistance in mice, and the ALLO mimetic drug alfaxalone may offer anxiolytic benefits without muscle-relaxant effects.
August 2023 in “Apple Academic Press eBooks” This review highlights that various parts of Eclipta prostrata contain compounds with potential antioxidant, anti-inflammatory, hepatoprotective, and hair growth-promoting effects, among other activities.
16 citations
,
November 2018 in “The journal of pain/Journal of pain” This study found that in a rat model, 14,15-EET may alleviate central poststroke pain by enhancing thalamic inhibition through neurosteroid signaling, potentially outperforming gabapentin in early-stage treatment.
January 2021 in “Figshare” This study found that Coenzyme Q10 delivered through transethosomes improved clinical outcomes for androgenic alopecia patients compared to CoQ10 solution.
June 2024 in “Korean Journal of Pharmacognosy” This study found that taxifolin glycosides isolated from Rhododendron mucronulatum showed promise for developing treatments for male pattern hair loss by inhibiting DHT production and enhancing hair growth-promoting factors.
December 2022 in “Research Square (Research Square)” This study found that an extract from the herbal medicine Ophioglossum vulgatum Linn. showed potential hair growth promotion and increased ATP and catalase activity in cell assays, suggesting its use in treating alopecia.
July 2016 in “Cancer Research” This study developed a topical botanical lotion for managing chemotherapy-induced hair loss in cancer patients, reporting that it improved hair recovery times by 5-16 weeks, reduced inflammation, and enhanced scalp collagen levels with no observed side effects.
36 citations
,
November 2005 in “Journal of The American Academy of Dermatology” This article discusses the potential of latanoprost for treating alopecia areata, but notes that well-controlled studies are still needed to confirm its effectiveness.
In a laboratory setting, this study reported that the n-butanol fraction of Urtica laetevirens Maxim. water extracts significantly inhibited 5α-reductase activity.
January 2025 in “International Journal of Advanced Research in Science Communication and Technology” This review summarizes the pharmacological and therapeutic uses of Calotropis gigantea latex, noting its traditional applications in treating skin diseases, wounds, and asthma, as well as its potential in addressing cancer, diabetes, and cardiovascular diseases due to its rich bioactive compound content.
March 2026 in “Tropical Journal of Natural Product Research” In this study, the bark extract of Albizia saponaria was analyzed for its metabolites and potential anti-alopecia effects, identifying several compounds with predicted affinities for proteins involved in hair loss pathways.
9 citations
,
January 2009 in “International Journal of PharmTech Research” This study found that a herbal oil formulation containing Eclipta alba, Hibiscus rosa sinensis, and Nardostachys jatamansi showed better hair growth effects in wister albino rats compared to 2% minoxidil.
5 citations
,
March 2023 in “PubMed” This review discusses the potential of advanced therapy medicinal products for treating vitiligo, highlighting promising results but noting affordability remains a challenge; no new clinical results were reported.
5 citations
,
November 2017 in “Asian journal of pharmaceutical and clinical research” This study found that water fractions of Angiopteris evecta stimulated hair growth in male rabbits, suggesting potential alopecia treatment benefits pending further research in humans.
9 citations
,
June 2014 in “Nutrition and Cancer” This study found that hydro-alcoholic Eclipta alba extract may have anticancer and multidrug resistance-reversal effects in animal models, suggesting potential as an adjunctive agent in tumor chemotherapy.
10 citations
,
November 2023 in “European Journal of Lipid Science and Technology” This study found that the ethanolic extract of walnut fruit diaphragm significantly improved lipid profiles, reduced oxidative stress, and had anti-inflammatory effects in hyperlipidemic rats.
November 2022 in “International Journal of Applied Pharmaceutics” This study found that phytosterols extracted from moringa seed oil may act as potential anti-alopecia agents by inhibiting the 5α-reductase enzyme, with ergostadienol showing particularly high affinity and stability in in silico simulations.
April 2024 in “Journal of ethnopharmacology” This study demonstrated that ellagic acid promoted hair regrowth in a DHT-induced androgenic alopecia mouse model by inhibiting ferroptosis through the activation of the Wnt/β-catenin signaling pathway, suggesting its potential as a treatment for androgenic alopecia.
March 2023 in “Journal of Applied Biomedicine” This study suggests that oleanolic acid may promote hair growth in mice with testosterone-induced androgenetic alopecia by activating the Wnt/β-catenin pathway and influencing various molecular levels.
13 citations
,
October 2017 in “Bioorganic & Medicinal Chemistry” This study found that compound 3, a tetrahydropyridoindole carboxymethylated at position 5, significantly inhibited sorbitol accumulation in both rat eye lenses and tissues affected by diabetes, indicating its potential as a lead compound for ALR2 inhibition.
4 citations
,
January 2010 in “International journal of trichology” Bexarotene gel shows promise as a new treatment for alopecia areata.
January 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study reports the discovery of LX-38, a new high-affinity non-steroidal antagonist that could provide the therapeutic benefits of current BPH and AGA treatments without the hormonal side effects, utilizing a distinct "Orthogonal T-Stacking" scaffold for binding.
141 citations
,
February 2005 in “Journal of the American Academy of Dermatology” In this study, oral prednisolone pulse therapy led to significant hair regrowth in some patients with extensive alopecia areata, whereas no improvement was seen in the placebo group.
49 citations
,
January 2017 in “Oxidative Medicine and Cellular Longevity” In this study, the alcoholic extract of Eclipta alba demonstrated significant anticancer activity in vitro by inducing apoptosis in breast cancer cell lines and showed strong antioxidant properties.
This study found that 1′S-1′-acetoxychavicol acetate from Alpinia galanga inhibits Nox isozymes and suppresses testosterone-induced hair loss in a mouse model of androgenetic alopecia.
January 2025 in “Figshare” This meta-analysis concluded that compound glycyrrhizin combined with conventional treatments improved hair regrowth in patients with alopecia areata, though it was associated with mild adverse events like edema.
January 2026 in “Dermatologic Therapy” This study found that Pinus massoniana needles extract may promote hair regrowth in a mouse model of androgenetic alopecia, potentially by reducing oxidative stress and affecting immune, metabolic, and apoptosis-related pathways.
August 2019 in “Journal of the American Academy of Dermatology” Ginseng and Albizia extracts help prevent hair thinning with age.
July 2026 in “Free Radical Biology and Medicine”