Walnut Fruit Diaphragm Ethanol Extract Ameliorates Damage Due to Triton WR-1339-Induced Hyperlipidemia in Rats

    November 2023 in “ European Journal of Lipid Science and Technology ”
    Esra Palabıyık, Ayşe Nurseli Sulumer, Handan Uğuz, Bahri Avcı, Seda Aşkın, Hakan Aşkın
    TLDR Walnut extract may help lower cholesterol and inflammation.
    The study investigates the effects of walnut fruit diaphragm ethanol extract (E-WFD) on hyperlipidemia induced by Triton WR-1339 in Wistar rats. The experiment involved 5 groups, including a healthy control and various treatment groups, each with 6 rats. E-WFD demonstrated lipid-lowering effects by reducing total cholesterol (TC) and triglycerides (TG) while increasing HDL-C levels. It also exhibited antioxidant potential by altering oxidative stress markers (MDA, SOD, CAT) and improved histopathological conditions in tissues. Furthermore, E-WFD significantly inhibited the expression of inflammatory biomarker genes (Tnf-α, Il-6, Il-1β, Mmp-2, Mmp-9, Lxr-α, Srebp-1c). These findings suggest that E-WFD could be a valuable alternative in treating hyperlipidemia, with potential applications in pharmacology, food, and cosmetics.
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