11 citations
,
June 2012 in “Archives of Dermatological Research” This study demonstrated that high doses of L-cystine and vitamin B6 effectively prevent doxorubicin-induced hair loss in mice.
41 citations
,
March 2007 in “Journal of dermatological science” This study found that oral administration of l-cystine with vitamin B6 effectively prevents environmental cigarette smoke-induced alopecia in mice by reducing hair bulb cell apoptosis.
26 citations
,
February 2003 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that cutaneous pyridoxal 5'-phosphate hydrolase activity may be carried out by an enzyme different from the classical tissue-nonspecific alkaline phosphatase in human and mouse skin.
7 citations
,
July 2021 in “Molecules/Molecules online/Molecules annual” This study demonstrated that an LC/MS-MS method could effectively detect and quantify the vitamin B3 vitamer nicotinamide in human hair, suggesting its potential use for long-term deficiency examination.
December 2025 in “Journal of Ovarian Research” This study found that multiple vitamins, including B6, increased the number of growing follicles in newborn mouse ovaries in vitro. VB6 promoted primordial follicle activation via the PI3K/Akt signaling pathway in both cultured mouse and human ovarian tissues.
7 citations
,
January 2001 in “PubMed” This study found that vitamin B6 injections over several weeks improved hair condition and reduced hair loss in some women with diffuse alopecia, while calcium pantothenate had no clear positive effect.
This study found that in mice, the combination of azelaic acid and vitamin B6 enhanced hair regrowth, follicle elongation, and thickness more than individual treatments.
June 2023 in “Italian journal of dermatology and venereology” In this study, researchers evaluated an oral supplement containing arginine, l-cystine, zinc, and vitamin B6, finding it effective as an adjuvant treatment for telogen effluvium, as indicated by improved hair quantity and diameter after three months in 18 patients.
4 citations
,
March 2006 in “Journal of renal nutrition” This study found that hemodialysis patients taking water-soluble vitamins had a 16% lower mortality risk compared to those not taking any, but the specific supplementation needed remains unclear.
10 citations
,
July 2022 in “Journal of the Turkish-German Gynecological Association” In this study, micronutrient intake was associated with androgen levels in women with PCOS, with the association more pronounced in NA PCOS compared to HA PCOS groups.
7 citations
,
July 2021 in “PubMed” This review assesses the role of vitamins A, B, C, and D in treating dermatologic conditions and highlights promising applications, although further research is required to confirm their efficacy.
2 citations
,
November 1995 in “American Journal of Obstetrics and Gynecology” This article reviews the need for multicenter clinical trials to establish reference data for ultrasound screening protocols for Down syndrome and reports no new findings.
1 citations
,
September 2022 in “Journal of dermatological science” This study found that a combination of vitamins in hair care products promoted hair shaft elongation in a mouse model by activating the PlGF/VEGFR-1 signaling pathway.
1 citations
,
January 1980 in “Side effects of drugs annual” This chapter reviews various adverse effects associated with vitamins, including hypercalcemia from high doses of vitamin A, hair loss from retinoid treatment, and complications with vitamin B6 in Parkinson's therapy, but reports no new clinical findings.
August 2025 in “International Journal for Vitamin and Nutrition Research” This review highlights the important role of the vitamin B complex in enhancing tissue repair, reducing inflammation, and improving surgical outcomes in plastic and reconstructive procedures by supporting cellular processes such as mitochondrial efficiency, neurotransmitter biosynthesis, and wound healing pathways.
September 2006 in “Baghdad Science Journal” This study suggests a link between hair loss experienced during pregnancy and lactation and inadequate daily intake of certain nutrients.
4 citations
,
March 2020 in “JAAD Case Reports” This case report describes a 47-year-old male with rare total melanonychia linked to vitamin B12 deficiency, whose nail discoloration and constitutional symptoms improved following vitamin B12 supplementation.
January 1987 in “Toxicological sciences” In this study, SMR-2 and SMR-6, retinoid analogs, were found to be approximately 100 times more toxic than retinoic acid in male mice, primarily affecting skin, immune, and reproductive systems.
52 citations
,
October 2016 in “Clinics in Dermatology” This review discusses various drugs that can cause drug-induced acne, noting specific clinical and histopathologic features, but reports no new clinical findings.
17 citations
,
October 2015 in “Medicine and Pharmacy Reports” This article reviews current research on animal models for hair regrowth treatments and reports no new findings; it highlights the need for studies comparing therapy efficiency and long-term safety.
14 citations
,
January 2020 in “Dermatology Online Journal” This article reviews the link between certain dietary supplements, such as vitamins B6/B12, iodine, whey, and muscle-building products, and acne, emphasizing the need for dermatologists to discuss supplement use with patients; it reports no new results.
7 citations
,
October 2020 in “Dermatology practical & conceptual” This review discusses the potential risks associated with skin, hair, and nail supplements, highlighting concerns about safety, efficacy, and lack of regulation but reports no new clinical results.
50 citations
,
November 2010 in “Otolaryngologic Clinics of North America” This review discusses the oral manifestations associated with hematologic conditions and nutritional deficiencies, without presenting new research results; it emphasizes the impact of blood disorders and vitamin deficiencies on oral health.
126 citations
,
January 2009 in “International Journal of Trichology” This review discusses the potential role of oxidative stress in hair graying and age-related alopecia, emphasizing the need for new strategies to counteract these effects, but reports no new results.
20 citations
,
November 1943 in “Experimental Biology and Medicine” This study found that inositol supplementation in rats improved growth and prevented hair loss, and combining it with folic acid and B6 resulted in even better growth rates.
14 citations
,
April 2000 in “Animal Science/Animal science” This article explores how various nutrients and metabolic processes impact wool and hair follicle function in animals but reports no new experimental findings.
10 citations
,
October 2021 in “Animal nutrition” This study found that dietary pyridoxine increased hair follicle density in Rex rabbits by activating PI3K/Akt, Wnt, and Notch signaling pathways, which may promote hair growth and delay telogen onset.
7 citations
,
January 2017 in “Journal of cosmetology & trichology” This article discusses how nutritional and environmental factors, along with antioxidant supplementation, may improve hair growth by mitigating the effects of androgens and reports no new clinical results.
3 citations
,
February 2017 in “The American journal of medicine” This case report highlights that repletion of various micronutrients, including thiamine, significantly improved heart failure symptoms and cardiac function in a malnourished patient with vitamin deficiencies.
1 citations
,
July 2012 in “EFSA journal” This report concludes that no cause and effect relationship has been established between consuming KF2BL20 and maintaining normal hair in healthy adults.