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Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.

Antiandrogens are effective for conditions like prostate cancer and skin issues, but more research is needed to confirm their benefits and minimize side effects.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

A young dog with an enlarged prostate and cysts improved significantly after treatment and surgery.

New treatments for enlarged prostate are being developed to be more effective and have fewer side effects.

Finasteride affects male rat genitalia development, causing abnormalities during specific pregnancy days.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Dutasteride reduces hospitalization and prostate cancer risk compared to finasteride, potentially offsetting its higher cost.

5-alpha-reductase inhibitors help treat urinary symptoms from an enlarged prostate.

Exposure to finasteride in the womb caused lasting reproductive issues in male rats.

Some skin diseases and their treatments can negatively affect male fertility.

Older adults still engage in sexual activities but face challenges like health issues and lack of professional support, highlighting the need for better healthcare provider education and research on sexual fulfillment in old age.

The document does not determine if adults with aphallia are fertile.

Different enzymes are active in different parts of developing mouse organs.

Finasteride lowers DHT levels and raises testosterone in a dose-dependent way.

Created method to measure doxazosin mesylate and finasteride together.

Finasteride may negatively affect male fertility.

Finasteride may help some male chronic pelvic pain patients, but more research needed.

Finasteride exposure in pregnancy causes genital abnormalities in male rats.

Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.

No consistent link between genotype and phenotype in 5-α-Reductase type 2 deficiency.

Hormonal therapy changes skin and hair in transgender patients, who need better researched dermatologic care.

The document concludes that sex hormones and related compounds have various effects on health, with both potential benefits and risks.

Surgeons must understand the full care process for gender confirmation surgery to help transgender individuals effectively.

The document concludes with guidance for doctors on diagnosing and treating hirsutism effectively and safely.

Delayed ejaculation is a complex issue caused by psychological, biological, and lifestyle factors, requiring a holistic treatment approach.

Scientists made safflower seeds produce a human growth factor that could help with hair growth and wound healing.

Red clover extract improved hair, skin, mood, sleep, and tiredness in postmenopausal women.

α-Blockers and 5-ARIs for BPH can cause sexual dysfunction, including erectile and ejaculatory issues.

Environmental factors and exposure to toxins may contribute to male infertility by affecting sperm and hormone function.