Expression of Bioactive Recombinant Human Fibroblast Growth Factor 10 in Carthamus Tinctorius L. Seeds

    September 2015 in “ Protein expression and purification ”
    Jian Huang, Jing Yang, Lili Guan, Shanyong Yi, Lina Du, Haishan Tian, Yongxin Guo, Feng Zhai, Zhou Lü, Haiyan Li, Xiaokun Li, Chao Jiang
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    TLDR Scientists made safflower seeds produce a human growth factor that could help with hair growth and wound healing.
    In the study from October 2017, researchers successfully expressed recombinant human fibroblast growth factor 10 (rhFGF10) in safflower (Carthamus tinctorius L.) seeds using oilbody-oleosin technology. They constructed a plant expression vector and introduced it into safflower plants through Agrobacterium tumefaciens transformation. The transformed plants were then grafted to obtain mature plants. The expression of oleosin-rhFGF10 was confirmed in the safflower seeds and was found to be heritable up to the T3 generation. Additionally, MTT assays indicated that the oil bodies expressing oleosin-FGF10 promoted cellular proliferation in a dose-dependent manner. This research suggests a potential method for producing rhFGF10 to meet its growing demand in pharmacology, particularly for applications in hair growth, tissue repair, and treatment of burn wounds.
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