Sex Hormones and Related Compounds, Including Hormonal Contraceptives
January 2015
in “
Side effects of drugs annual
”
sex hormones hormonal contraceptives hormone replacement therapy diethylstilbestrol tissue selective estrogen complexes metabolism body composition cancer risks obesity breast cancer myocardial hypertrophy polycystic ovary syndrome PCOS etonogestrel implants anabolic androgenic steroids antiandrogens 5alpha-reductase inhibitors DES TSECs AAS
TLDR The document concludes that sex hormones and related compounds have various effects on health, with both potential benefits and risks.
The document from 2015 examines the adverse effects and potential benefits of sex hormones and related compounds, including hormonal contraceptives and hormone replacement therapy. It discusses the long-term consequences of diethylstilbestrol (DES) exposure, the varying effects of hormone replacement therapy on health outcomes, and the introduction of tissue selective estrogen complexes (TSECs) for menopausal therapy. The document also explores the impact of hormonal contraceptives on metabolism, body composition, and cancer risks, citing studies with varying numbers of participants, such as a study with 32 women on contraceptive regimens, the Nurses' Health Study with 121,701 participants, and a case-control study with 985 cases and 882 controls. Additionally, it reviews the effects of sex hormones on conditions like obesity, breast cancer, myocardial hypertrophy, and polycystic ovary syndrome (PCOS), mentioning studies on mice and human subjects, including a study on premenopausal women with breast cancer and a case report on etonogestrel implants for cystic fibrosis. The document also addresses the risks associated with anabolic androgenic steroids (AAS), antiandrogens, and 5alpha-reductase inhibitors, highlighting the need for awareness of these potential adverse effects.
