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The document concludes that understanding genetic mutations in the PI3K-AKT-mTOR pathway can lead to better diagnosis and treatment for certain genetic skin disorders.

Selecting specific KRTAP26-1 gene variants can improve wool quality in sheep.

Deoxyshikonin helps wounds heal faster in diabetic mice.

Metformin may help treat neuroendocrine tumors.

Men have more tryptophan in their hair than women, and it increases with age and is higher in darker and grey or white hair.

The KRTAP11-1 gene promoter is crucial for specific expression in sheep wool cortex.

Caffeine may help reduce stress-induced hair loss.

A protein found in safflower seeds can stimulate hair growth and speed up wound healing in mice.

More high-quality research is needed to recommend flavonoids and saponins for clinical use.

Norepinephrine helps skin cells grow, which is important for hair growth.

GDNF helps grow hair and heal skin wounds by acting on hair stem cells.

Safflower oil nanoparticles can deliver hFGF10 to hair follicles, reduce inflammation, and potentially speed up hair growth in conditions causing hair loss.

The KRTAP21-1 gene affects wool yield and can help improve wool production.

Saw palmetto extract may help treat brain tumors by blocking a specific growth signal and blood vessel formation.

The KRTAP21-2 gene affects wool length and quality in sheep.

Allium hookeri extract may help promote hair growth and protect cells from damage.

ZO-1 helps hair follicle stem cells renew better by changing their structure.

A substance called miR-1246 may help treat severe hair loss by reducing certain immune cell activities.

Variant G of the KRTAP20-1 gene improves wool curliness in Chinese Tan sheep.

High levels of ST14 and TMEFF1 proteins in ovarian cancer are linked to worse patient outcomes and may be a new treatment target.

The KRTAP36-2 gene in sheep affects wool yield.

Cactus extract from Notocactus ottonis may help promote hair growth.

The treatment effectively promotes hair regrowth in androgenetic alopecia without causing skin irritation.

IGF-1R may play a role in female hair loss and could be a treatment target.

Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.

Hydrogel scaffolds can help wounds heal better and grow hair.

Hair follicles prevent NK cell attacks to avoid hair loss.

TNFα helps grow and maintain liver cells in 3D culture for a long time.

ERG increases SOX9, promoting prostate cancer growth and invasion.

Researchers created a mouse with the same mutation as humans with trichothiodystrophy, showing similar symptoms and confirming the condition is due to defects in DNA repair and gene activity.