Beneficial Effects of Deoxyshikonin on Delayed Wound Healing in Diabetic Mice

    November 2018 in “ International Journal of Molecular Sciences ”
    Jun Yeon Park, Myoung‐Sook Shin, Gwi Seo Hwang, Noriko Yamabe, Jeong‐Eun Yoo, Ki Sung Kang, Jin‐Chul Kim, Jeong Gun Lee, Jungyeob Ham, Hye Lim Lee
    TLDR Deoxyshikonin helps wounds heal faster in diabetic mice.
    The study investigated the effects of deoxyshikonin, a compound from Lithospermi Radix (LR), on wound healing in diabetic mice. Deoxyshikonin was found to enhance tube formation in human umbilical vein endothelial cells (HUVECs) under high glucose conditions, likely through increased VEGFR2 expression and phosphorylation of Akt and p38. Topical application of deoxyshikonin on open skin wounds in streptozotocin (STZ)-induced diabetic mice promoted wound repair. These findings suggested that deoxyshikonin, an active ingredient of LR, could aid in wound healing for diabetic patients.
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