research The Effect of 5-Reductase Inhibitors on Erectile Function
5-alpha-reductase inhibitors may cause a low incidence of erectile dysfunction that decreases over time.
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research Finasteride Is the Main Inhibitor of 5α-Reductase Activity in Microdissected Dermal Papillae of Human Hair Follicles
Finasteride potentially treats hair loss by reducing DHT production.
research Higher Levels of Steroidogenic Acute Regulatory Protein and Type I 3β-Hydroxysteroid Dehydrogenase in the Scalp of Men with Androgenetic Alopecia
Men with baldness have higher levels of specific proteins, suggesting local hormone production may play a role in hair loss.
research Discovery of a Novel Hybrid from Finasteride and Epristeride as 5α-Reductase Inhibitor
New hybrid compound found to effectively prevent hair loss.
research Enhanced Skin Permeation of 5α-Reductase Inhibitors Entrapped into Surface-Modified Liquid Crystalline Nanoparticles
Special nanoparticles increased skin absorption of hair loss treatments with fewer side effects.
research 5α-Reductase Inhibitors and Male Reproduction
5α-Reductase inhibitors can negatively affect male sexual function and, in some cases, significantly reduce sperm count, but these effects may be reversible.
research A New Look at the 5-Alpha-Reductase Inhibitor Finasteride
Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.
research Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men With Suppressed Testosterone Production
Testosterone's muscle-building effects do not require its conversion to DHT.
research The Human Type I Keratin Gene Family: Characterization of New Hair Follicle Specific Members and Evaluation of the Chromosome 17q21.2 Gene Domain
The study identified and characterized new keratin genes linked to hair follicles and epithelial tissues.
research Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride
Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.
research Curcuma Aeruginosa, A Novel Botanically Derived 5α-Reductase Inhibitor In The Treatment Of Male-Pattern Baldness: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study
Curcuma aeruginosa extract combined with minoxidil effectively treats male-pattern baldness.
research The Impact of 5α-Reductase Inhibitor Use for Male Pattern Hair Loss on Men's Health
Hair loss drugs may cause sexual issues and infertility in men.
research Selective Induction of Apoptosis in the Hamster Flank Sebaceous Gland Organ by a Topical Liposome 5-Alpha-Reductase Inhibitor: A Treatment Strategy for Acne
A topical treatment safely and effectively reduced acne by causing targeted cell death in sebaceous glands without side effects.
research Effects of 5-Alpha Reductase Inhibitors on Lung Function: A Reason for Discontinuation During COVID-19 Pandemic?
5-alpha reductase inhibitors might worsen lung recovery in COVID-19 patients, suggesting a pause in their use.
research Do 5α-Reductase Inhibitors Raise Circulating Serum Testosterone Levels? A Comprehensive Review and Meta-Analysis Explaining Paradoxical Results
5α-Reductase inhibitors do not consistently increase testosterone levels in the blood.
research Three-Dimensional Proteome-Wide Scale Screening for the 5-Alpha Reductase Inhibitor Finasteride: Identification of a Novel Off-Target
Finasteride may affect PNMT, causing side effects.
research Comparative Efficacy and Safety of JAK Inhibitors in the Treatment of Moderate-to-Severe Alopecia Areata: A Systematic Review and Network Meta-Analysis
Brepocitinib 30mg is most effective for moderate-to-severe alopecia areata, but ritlecitinib 50mg may offer a better balance of safety and effectiveness.
research 5-Alpha Reductase Inhibitors: New Evidence on Benefits and Harms Beyond Benign Prostatic Hyperplasia
5-alpha reductase inhibitors may have additional effects on cancer, mental health, heart health, and hormone levels beyond treating prostate enlargement.
research Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients
Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.
research In Vitro and In Vivo Skin Distribution of 5α-Reductase Inhibitors Loaded Into Liquid Crystalline Nanoparticles
Chitosan-coated nanoparticles improve skin delivery of hair loss treatments with fewer side effects.
research Type I Keratin 17 Protein Is Phosphorylated on Serine 44 by p90 Ribosomal Protein S6 Kinase 1 in a Growth- and Stress-Dependent Fashion
Keratin 17 is modified by RSK1 in response to growth and stress, affecting skin growth and stress response.
research The 5α-Reductase Inhibitor Dutasteride but Not Finasteride Protects Dopamine Neurons in the MPTP Mouse Model of Parkinson’s Disease
Dutasteride protects dopamine neurons in Parkinson's mice, but Finasteride doesn't.
research Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth
Substance from human umbilical cord blood cells promotes hair growth.
research Inhibitory Effects of Apple Polyphenols on Differentiation of 3T3-L1 Cells into Adipocytes
Apple polyphenols, especially from unripe apples, can help prevent cells from turning into fat cells.
research A New Label-Free Screen for Steroid 5α-Reductase Inhibitors Using LC-MS
Researchers developed a new method to find substances in herbs that can block a specific enzyme linked to hair loss.
research Finasteride, a 5α-Reductase Inhibitor, Potentiates Antinociceptive Effects of Morphine, Prevents the Development of Morphine Tolerance and Attenuates Abstinence Behavior in the Rat
Finasteride boosts morphine's pain relief, stops tolerance, and reduces withdrawal in rats.
research Novel ALK5 Inhibitor TP0427736 Reduces TGF-β Induced Growth Inhibition in Human Outer Root Sheath Cells and Elongates Anagen Phase in Mouse Hair Follicles
TP0427736 may help treat hair loss by blocking a specific protein and promoting hair growth.
research Hair Follicle Characteristics as Early Marker of Type 2 Diabetes
Hair characteristics might be early signs of Type 2 Diabetes and could help with early prevention.
research Anti-Androgenic Curcumin Analogues as Steroid 5-Alpha Reductase Inhibitors
Some curcumin-like compounds can effectively and safely block the enzyme linked to hair loss and other conditions related to male hormones.
research Phenolic Composition, Enzyme Inhibitory, and Antioxidant Activity of Bituminaria Bituminosa
The water extract of Bituminaria bituminosa, high in phenolic compounds, shows strong antioxidant and enzyme inhibitory potential.