research Essential Role of STAT3 Signaling in Hair Follicle Homeostasis
STAT3 signaling is important for healthy skin and hair follicles, and its disruption can lead to skin conditions like atopic dermatitis.
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research In Silico Analysis of the Age-Dependent Evolution of the Transcriptome of Mouse Skin Stem Cells
The research found that the gene activity in mouse skin stem cells changes significantly as they age.
research Anti-Proliferative Effect of Terpenes on Human Prostate Cancer Cells: Natural Sources and Their Potential Role as Chemopreventive Agents
Certain natural compounds called terpenes may help prevent prostate cancer.
research Metabolic Regulation of Stem Cells in Aging
Eating less can improve stem cell function and increase lifespan.
research Aging and Anti-Aging in Hair and Hair Loss
Hair ages and thins due to factors like inflammation and stress, and treatments like antioxidants and hormones might improve hair health.
research Shushing Down the Epigenetic Landscape Towards Stem Cell Differentiation
The document concludes that pig iPSCs show promise for transplant therapies and the field is advancing in controlling cell behavior for biology and medicine.
research Molecular Heterogeneity of Quiescent Melanocyte Stem Cells Revealed by Single-Cell RNA-Sequencing
Different types of inactive melanocyte stem cells exist with unique characteristics and potential to develop into other cells.
research Signaling Pathways in Hair Aging
Hair aging is caused by stress, hormones, inflammation, and DNA damage affecting hair growth and color.
research The Rho GTPase Exchange Factor Vav2 Promotes Extensive Age-Dependent Rewiring of the Hair Follicle Stem Cell Transcriptome
Vav2 changes how hair follicle stem cells' genes work as they age, which might improve regeneration but also raise cancer risk.
research Data from Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened
The treatment was ineffective in humans.
research 266 Myristoylphorbol Acetate (MPA) Enhances Metastasis Via Up-Regulation of Eph A2 Transcription Activity
MPA increases cancer spread by boosting Eph A2 activity.
research BMI1 Is Required for Melanocyte Stem Cell Maintenance and Hair Pigmentation
BMI1 is essential for preventing hair greying and maintaining hair color.
research Cyclin-Dependent Kinase 4 Expression Alters the Number of Keratinocyte Stem Cells in the Mouse Hair Follicle
Changing CDK4 levels affects the number of stem cells in mouse hair follicles.
research The Rational Role Of Polyamines In Epidermal Differentiation
The study by Rahim et al. (2021) investigated the role of polyamines in epidermal differentiation, focusing on the polyamine regulator AMD1. It was discovered that keratinocyte differentiation required a shift in polyamine ratios, particularly an increase in spermine levels facilitated by AMD1, which was essential for proper differentiation. This shift occurred through elevated translation of AMD1 mRNA rather than increased mRNA expression. The research suggested that manipulating polyamine availability could be advantageous in treating hyperproliferative skin disorders such as psoriasis and skin cancer. The study highlighted that the specific ratios between different polyamine species, rather than their accumulation, were vital for maintaining epidermal homeostasis and managing diseases.
research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis
Hair follicle stem cells can form both hair follicles and skin.
research An Estrogen Receptor Pathway Regulates the Telogen-Anagen Hair Follicle Transition and Influences Epidermal Cell Proliferation
Estrogen affects hair growth and skin cell multiplication.
research Micro-RNA-31 Controls Hair Cycle-Associated Changes in Gene Expression Programs of the Skin and Hair Follicle
miR-31 regulates hair growth by controlling gene expression in hair follicles.
research Epidermal Stem Cells in Wound Healing and Their Clinical Applications
Epidermal stem cells help heal severe skin wounds and have potential for medical treatments.
research LGR5 Is a Marker of Poor Prognosis in Glioblastoma and Is Required for Survival of Brain Cancer Stem-Like Cells
High LGR5 levels in glioblastoma indicate poor prognosis and are essential for cancer stem cell survival.
research The Molecular Revolution in Cutaneous Biology: Noncoding RNAs as New Molecular Players in Dermatology and Cutaneous Biology
Non-coding RNAs are crucial for skin development and health.
research Red Ginseng (Panax Ginseng Meyer) Oil: A Comprehensive Review of Extraction Technologies, Chemical Composition, Health Benefits, Molecular Mechanisms, and Safety
Red ginseng oil is believed to have various health benefits and is safe, but more research is needed to fully understand how it works.
research MAIT Cells in COVID-19: Heroes, Villains, or Both?
MAIT cells may help fight COVID-19 but also contribute to severe inflammation.
research The Potential Impact of Melanosomal pH and Metabolism on Melanoma
Melanin may help melanoma cells grow by aiding their metabolism.
research Research Techniques Made Simple: Zebrafish Models for Human Dermatologic Disease
Zebrafish are useful for studying and developing treatments for human skin diseases.
research Controlling Hair Loss by Regulating Apoptosis in Hair Follicles: A Comprehensive Overview
Regulating cell death in hair follicles can help prevent hair loss and promote hair growth.
research Network Pharmacology Reveals Curcuma Aeruginosa Roxb. Regulates MAPK and HIF-1 Pathways to Treat Androgenetic Alopecia
Curcuma aeruginosa Roxb. may help treat hair loss by affecting specific biological pathways.
research Molecular Mechanisms of Y Chromosome Loss and UTY Gene Activity
Loss of the Y chromosome and UTY gene activity increases cancer risk in men.
research Melanoma: Genetic Abnormalities, Tumor Progression, Clonal Evolution, And Tumor-Initiating Cells
Melanoma's complexity requires personalized treatments due to key genetic mutations and tumor-initiating cells.
research Common Pathologic Pathways: A Single Prescription Dream?
The conclusion suggests that treatments targeting root causes of chronic diseases may be developed by focusing on gene expression and lifestyle factors.
research Short-Term Biomarkers of Cigarette Smoke Condensate Tumor Promoting Potential in Mouse Skin
The study investigated the effects of cigarette smoke condensates (CSCs) on mouse skin, focusing on hyperplasia and inflammation as short-term biomarkers of tumor promotion. Using a truncated initiation-promotion protocol, the research assessed epidermal thickness, proliferative index, and ornithine decarboxylase (ODC) expression after CSC application. Results showed that CSCs increased these markers, with partial reversibility in interfollicular areas but sustained elevation in perifollicular regions. The study highlighted perifollicular ODC expression as a promising indicator for evaluating CSCs due to its rapid induction, low threshold, and potential to reflect irreversible changes, aligning with the notion that ODC expression is crucial for tumor promotion and that tumors primarily originate in the perifollicular epidermis.