6 citations
,
August 2007 in “Journal of Surgical Research” In this study, constitutive expression of Del1 in mice did not affect wound healing but was associated with increased hair growth following anagen induction.
5 citations
,
January 2024 in “The International Journal of Developmental Biology” This article reviews the diversity of lymphatic endothelial cells, related gene targeting tools, and protocols in mouse models but presents no new experimental findings.
5 citations
,
July 1999 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” The researchers reported that applying proteolytic enzymes to mice skin negatively affected hair follicles, leading to degeneration and potential impairment of stem cells from the bulge area.
2 citations
,
June 2006 in “Experimental dermatology” This article discusses the development of skin patterns during embryogenesis and postnatal life, linking them to genetic, environmental, and mathematical factors, but presents no new empirical findings.
This study discovered that in *Drosophila*, knockdown of specific storage proteins in adipocytes decreased germline stem cell maintenance, implicating a role for these proteins in adult tissue regulation.
This study found that elastin-like recombinamer (ELR) wound dressings promote tissue regeneration and stability without rejection in ex vivo and in vivo models, indicating potential for hard-to-heal wound treatment.
June 2023 in “Historical records of Australian science/Historical Records of Australian Science” This biographical abstract highlights George Rogers' pioneering contributions to the understanding of keratin molecular structure and keratinisation biochemistry, including the application of electron microscopy to hair ultrastructure and the discovery of enzymes and gene transcription processes relevant to keratin proteins.
November 2022 in “Gigascience” This study identified a 582-bp deletion upstream of LHX2 in cashmere goats, likely linked to hair follicle development and cashmere production, providing insights into genetic factors in cashmere trait selection.
September 2021 in “Research Square (Research Square)” This study reports that despite rescuing neurulation and skin barrier defects, Grhl3 gene overexpression in mice leads to hearing impairment, hair loss, and other developmental abnormalities, highlighting low tolerance for Grhl3 dysregulation.
June 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study discovered that the gene Tfap2b identifies a melanocyte stem cell population in zebrafish, essential for regenerating melanocytes with multi-fate potential into adult pigment cells.
September 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that zebrafish and stickleback fish use similar genetic programs for tooth regeneration, despite differences in their dental structures.
June 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that the HoxC gene cluster is crucial for the development of hair and nails in mice, with key regulation by two mammalian-specific enhancers.
October 2018 in “Current Opinion in Genetics & Development” The document emphasizes the importance of ongoing research and ethical considerations in genome editing and cellular reprogramming.
April 2003 in “Experimental Dermatology” This workshop review from the Australian Hair and Wool Research Society discusses findings in cutaneous biology and endocrinology but presents no new research results.
271 citations
,
March 1999 in “Developmental biology” This study reveals that overexpression of Wnt3 in transgenic mouse skin leads to a short-hair phenotype and cyclical balding due to structural defects in hair shafts, highlighting a role for WNT signaling in hair growth regulation.
January 2011 in “Zhongguo nongye Kexue” This study successfully established a transgenic sheep fibroblast cell line expressing the spider dragline silk protein gene, laying groundwork for developing transgenic sheep with this capability in hair follicles.
58 citations
,
July 2005 in “Molecular and Cellular Biology” This study showed that a 2-kilobase upstream region of the mouse keratin 17 gene enables targeted GFP expression in major epithelial appendages of transgenic mice, indicating sonic hedgehog's involvement in its regulation.
July 2002 in “Science Signaling” This study found that in a transgenic mouse model, a modified form of β-catenin inhibited normal hair follicle development and promoted epidermal cyst formation, revealing distinct effects on Wnt signaling.
18 citations
,
June 2011 in “Cell stem cell” Two studies in Cell Stem Cell reported that human and mouse somatic cells can be reprogrammed into induced pluripotent stem cells using microRNAs, eliminating the need for ectopic protein expression.
1533 citations
,
October 2008 in “Endocrine reviews” This research highlights that engineered mice lacking the vitamin D receptor show multiple health issues similar to human vitamin D deficiency, underscoring the widespread impacts of the vitamin D endocrine system.
1398 citations
,
May 2008 in “Histochemistry and Cell Biology” This review summarizes the cell type distribution and functional significance of human keratins, emphasizing their roles in tumor diagnosis and potential clinical applications, and reports no new clinical findings.
855 citations
,
June 2009 in “The Journal of Clinical Endocrinology & Metabolism” The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.
688 citations
,
June 2007 in “Cell Stem Cell” This study found that deleting the ATR gene in adult mice led to rapid onset of age-related traits such as hair graying and osteoporosis through reduced regenerative capacity.
555 citations
,
July 2001 in “Genes & Development” This study found that Tcf3 and Lef1 differently regulate cell differentiation in multipotent skin stem cells, with Tcf3 promoting follicle-like features and Lef1, when modified, promoting sebocyte differentiation.
475 citations
,
January 2016 in “International Review of Psychiatry” This review discusses genderqueer and non-binary identities and explores how mental health professionals can support these marginalized communities, but it reports no new findings.
417 citations
,
September 2005 in “PLoS biology” This study developed molecular signatures for dermal papilla cells and their niche, uncovering novel signaling regulators and genes linked to hair disorders, which may inform future hair development research.
384 citations
,
June 2005 in “Genes & development” This study found that stabilized beta-catenin is crucial for activating stem cell transition from quiescence to proliferation in hair follicles by influencing gene expression within the stem cell niche.
295 citations
,
September 2006 in “Cell Cycle” This review discusses the role of the TOR pathway in aging and suggests that rapamycin could potentially target age-related diseases, but reports no new clinical results.
260 citations
,
December 2012 in “Cold Spring Harbor Perspectives in Biology” This review discusses the significant role of Wnt signaling in skin development, homeostasis, and disease, highlighting recent advances in understanding its diverse functions, but reports no new experimental results.
254 citations
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January 2012 in “Nature Reviews Molecular Cell Biology” This review discusses the role of stem cell progeny as integral components of stem cell niches, offering feedback that may influence different stem cell systems' microenvironments, but it presents no new research findings.