Distinct Tooth Regeneration Systems Deploy a Conserved Battery of Genes

    September 2020 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Tyler A. Square, Shivani Sundaram, Emma J. Mackey, Craig T. Miller
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    TLDR Different fish use the same genes to regrow teeth.
    The study compared tooth regeneration in zebrafish and threespine stickleback, two ray-finned fishes with different dental morphologies. Despite these differences, both species exhibited similar genetic programs during tooth regeneration, including the upregulation of Wnt signaling and Lef1 expression, and the expression of nine specific genes (Bmpr1a, Bmp6, CD34, Gli1, Igfbp5a, Lgr4, Lgr6, Nfatc1, and Pitx2). This suggested a conserved "successional dental epithelium" (SDE) across vertebrates. The findings also implied that similar genetic mechanisms might be used in other epithelial appendages, such as hair follicles in mice.
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