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This study used scRNA-Seq to map the transcriptional changes during zebrafish hair cell regeneration, revealing distinct phases including injury response, transient regeneration gene activation, and reactivation of developmental programs.

This study provided a detailed molecular profile of Cashmere goat hair follicle development using single-cell RNA sequencing, revealing unique cell populations and conserved developmental programs compared to mouse models.

In this study, researchers observed distinct aging signatures in mouse keratinocytes, with increased expression in older mice, and noted relevant pathway changes that were also evident in human skin, suggesting potential insights into intrinsic skin aging.

This study used single-cell RNA sequencing to identify at least nine subpopulations of keratinocytes in human neonatal epidermis, revealing unexpected heterogeneity and complex differentiation trajectories.

This study found that upper wound fibroblasts are crucial for hair follicle regeneration during wound healing and suggests that these cells, along with papillary fibroblasts, migrate within the wound.

This review highlights recent research using single-cell RNA sequencing and machine learning in wound healing, revealing significant insights into fibroblast diversity, immune cell dynamics, and the spatial organization of cells, which may transform therapeutic strategies for chronic wounds, fibrosis, and tissue regeneration.

This study used single-cell RNA sequencing to analyze 26,573 cells from the scapular skin of yaks, identifying 11 major cell types and providing insights into the diversity and morphogenesis of hair follicle cell types through detailed maps of DP cells and dermal fibroblasts.

This study identified CD28, GZMB, and CD1C as key immune regulators in alopecia areata, highlighting CD28 as a potential therapeutic target with a promising safety profile, using a proteome-anchored multi-omics approach to uncover actionable targets for this autoimmune hair-loss disorder.

In this study, human dermal papilla cells exposed to wasabi leaf extract showed changes in cytokine-related gene expression, which the authors suggest could help clarify the biological effects of wasabi.

This study identified key genes and signaling pathways involved in cashmere goat hair follicle growth cycles, influenced by melatonin implantation, suggesting a basis for further research on melatonin's regulatory mechanism.

In this study, CD4+ non-haematopoietic, skin-resident stem cell-like populations were identified in both murine and human epidermis, suggesting they may serve as potential basal cell carcinoma precursors.

This study established a new in vitro culture system that supports the growth and dynamic self-organization of hair follicle stem cells and their progeny, promoting a stable population equilibrium.

This study observed that specific genes in cashmere goat skin exhibit a seasonal rhythm, potentially adapting to environmental light changes, which may affect downstream gene expression and physiological processes.

This study generated a transcriptomic map of human hair follicle compartments, providing a database for identifying compartment-specific gene expression which may aid in developing targeted treatments for hair follicle disorders.

This study identified key genes and miRNAs involved in feather morphogenesis in Zhedong White geese, highlighting a negative correlation between FOXO3 and miR-144-y.

This study shows that in a mouse model of Alopecia Areata, selective JAK1 inhibition facilitated hair regrowth and inflammation resolution while potentially offering a better safety profile compared to pan-JAK inhibition.

In this study, researchers found that the loss of SETDB1 in epidermal keratinocytes led to altered chromatin states, increased ERV expression, and activation of immune responses, while inhibiting these effects with certain antiviral drugs reduced skin inflammation and hair loss in a mouse model.

The research aims to better understand hair follicle regulation and find new treatments for hair loss.

This research reexamined transcriptomic data to study stem and progenitor cell proliferation in psoriasis, finding that the number of committed progenitor cells increased eight-fold in psoriatic skin without altering stem cell numbers, potentially identifying new therapeutic targets.

In this study, researchers used single-cell RNA sequencing to identify seven cell types, including distinct steroidogenic and immune cells, in the tumor microenvironment of a case of ovarian SCT-NOS, providing insights into its cellular heterogeneity and molecular mechanisms related to hyperandrogenism.

In this study, whole-genome sequencing of Lanping black-boned sheep identified ERBB4 and ROR1 genes as potentially important in their distinctive hyperpigmentation, enhancing understanding of their genetic evolution from Lanping normal sheep.

This study reported the first comprehensive transcriptome atlas of the extraorbital lacrimal gland in mice, identifying over 41 cell subclasses and revealing significant cell-cell communication networks, particularly among innate lymphoid cells.

This study identified a stable combination of house-keeping genes, NCBP3 + SDHA + PTPRA, for normalizing gene expression in goat skin tissues using RNA sequencing.

In this study, researchers used transcriptomics and modeling to uncover previously unknown cell populations and marker genes in developing hair follicles, providing insights into early cell fate establishment and offering tools for further research on skin appendages.

This research detailed a single-cell atlas showing dynamic hair follicle stem cell states associated with the hair cycle during aging in mice, highlighting differences in chromatin landscape linked to stem cell differentiation and quiescence, and providing a foundation for future exploration of aging reversal.

In this study, researchers identified thousands of mRNA, lncRNA, circRNA, and miRNA transcripts involved in different hair follicle stages of Rex rabbits and highlighted significant gene expression changes and pathway enrichments, providing insights into the regulatory mechanisms of hair development in these animals.

This study used single-cell and spatial transcriptomic profiling to identify specific molecular markers in human follicular dermal papilla cells, enhancing understanding of their role in hair follicle development.

In this single-cell transcriptomic study, researchers analyzed AA scalp samples and found distinct immune and nonimmune cell activation patterns, with elevated TH1/TH2 and JAK/STAT markers potentially contributing to hair follicle immune privilege disruption and disease severity.

This study identified the placenta at the base of the ovary as the origin of poplar seed hair development and detailed transcriptome dynamics during the growth process.

This study suggests that UMPP activation is a key signaling pathway in differentiating primary and secondary hair follicles in cashmere goats.