Functional Analysis of the PIP5K1A Gene in Liaoning Cashmere Goats: An Investigation Based on Bioinformatics, Tissue Localization, and Biological Functions

The study explores the PIP5K1A gene in Liaoning Cashmere goats, highlighting its role in skin fibroblast proliferation and cashmere growth. PIP5K1A is a soluble, unstable protein expressed in the outer root sheath of hair follicles. Melatonin enhances PIP5K1A expression, promoting cell proliferation, while interference with PIP5K1A reverses this effect. Overexpression of PIP5K1A downregulates miRNAs chi-miR-34c-5p and chi-miR-novel-86, indicating a regulatory role in cashmere growth. The research provides insights into improving cashmere yield and quality through genetic and molecular approaches, suggesting a feedback loop between PIP5K1A and miR-34c-5p in hair growth mechanisms.