November 2020 in “ALEXMED ePosters (Online)” In this study, researchers found that hirsutism in Egyptian women with PCOS was associated with higher testosterone levels, while acne and androgenetic alopecia did not correlate with androgen levels or insulin resistance.
April 2020 in “Journal of the Endocrine Society” This case report details a post-menopausal woman with hirsutism and virilization due to rare Leydig cell tumors in both ovaries, underscoring the challenge of detecting such tumors with standard imaging.
April 2020 in “Journal of the Endocrine Society” This case report emphasizes the importance of early diagnosis of Swyer Syndrome in adolescents with slow pubertal progression and primary amenorrhea due to the high risk of germ cell cancers.
April 2019 in “Journal of the Endocrine Society” This case report described a 62-year-old postmenopausal woman with hirsutism whose symptoms improved after a hysterectomy and bilateral oophorectomy, revealing bilateral ovarian hyperthecosis.
September 2004 in “Fertility and Sterility” Norplant implants lower some androgen levels but don't significantly change sexual function.
May 2017 in “Endocrine Abstracts” This study found that men with early-onset androgenetic alopecia who also met criteria for the male PCOS-equivalent may have impaired gonadal steroidogenesis, suggesting increased risk of future gonadal dysfunction.
8 citations
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January 1986 in “Journal of hepatology” This study suggests that hepatocellular carcinoma in cirrhotic men is associated with altered sex-steroid metabolism, indicated by lower testosterone and 5 alpha-dihydrotestosterone levels compared to cirrhosis alone.
September 2023 in “Journal of The American Academy of Dermatology” This study found that adolescents with androgenetic alopecia showed distinct hormonal profiles between boys and girls, with concurrent metabolic dysfunction present in both sexes, highlighting the need for sex-specific diagnosis and management approaches.
177 citations
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June 1991 in “The Journal of Clinical Endocrinology & Metabolism” This study found that caucasian subjects had higher serum levels of 5 alpha-reduced androgen metabolites compared to Chinese subjects, suggesting racial differences in 5 alpha-reductase activity and a potential mechanism for increased body hair in caucasian men.
12 citations
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April 1987 in “PubMed” In this study, low-dose spironolactone effectively reduced hirsutism in women and stopped hair loss in one woman with alopecia areata, without significant side effects over 12 menstrual cycles.
6 citations
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January 2009 In PCOS, high male hormones cause hair growth, acne, and hair loss, affecting periods.
October 2025 in “Zagazig University Medical Journal” In this study, an Egyptian cohort with PCOS showed a high prevalence of skin issues like hirsutism and acne compared to controls, with hirsutism linked to higher androgen levels, while other factors also influenced acne and alopecia.
September 2025 in “Scientific periodicals of Ukraine” This study found that a 3-month treatment with metformin significantly reduced serum luteinizing hormone, FSH, and testosterone concentrations in women with PCOS.
January 2016 in “Indian journal of clinical and experimental dermatology” This study reported that young males with early onset androgenetic alopecia had higher testosterone levels, but did not show a significant difference in insulin resistance or metabolic syndrome compared to controls.
90 citations
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February 2000 in “Dermatologic Surgery” This study concluded that the long-pulsed alexandrite laser is safe for hair removal in patients with Fitzpatrick skin types IV-VI, with complications occurring in only 2% of cases.
60 citations
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April 2003 in “Human Reproduction” This study found that Czech women with polycystic ovary syndrome in their thirties had a significantly worse cardiovascular risk profile compared to a control group, independent of obesity.
34 citations
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December 2007 in “Human Reproduction Update” This review discusses the limitations of current androgen measurement techniques using immunoassays and explores the potential of novel in vitro bioassays for clinical research applications, but it reports no new clinical results.
25 citations
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August 2016 in “Journal of Cosmetic Dermatology” This study found that a marine complex supplement significantly reduced hair shedding and increased hair growth in men with thinning hair over 180 days.
19 citations
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August 1999 in “European journal of endocrinology” This study concluded that neither basal nor ACTH-stimulated 17-OHP concentrations effectively indicate carrier status for 21-hydroxylase deficiency among Slovenian hyperandrogenic women, recommending molecular analysis of the CYP21 gene for reliable screening.
15 citations
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September 2023 in “International Journal of Microbiology Research” This study suggests that anti-Müllerian hormone (AMH) is the most promising biomarker for diagnosing polycystic ovary syndrome (PCOS), especially in women with phenotype A and D.
15 citations
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January 2017 in “Advances in Experimental Medicine and Biology” This review discusses the effects of 5ARI drugs on male reproductive parameters, reporting potential decreases in sperm count and motility more significantly in men with pre-existing oligozoospermia, but does not provide fertility outcomes.
13 citations
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October 2002 in “Journal of Biochemical and Biophysical Methods” This study found that men with androgenic alopecia had significantly higher levels of certain urinary steroid metabolites, suggesting increased 5 alpha-reductase activity and possible mild hyperadrenal activity.
4 citations
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May 2020 in “Annals of palliative medicine” In this clinical study, plum blossom needle acupuncture and qi-invigorating therapy were reported to be more effective than conventional Western medicine for treating seborrheic alopecia, as they improved hormone levels, reduced hair loss, and stimulated hair growth among the 87 patients observed.
4 citations
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November 1996 in “European journal of endocrinology” This study found that spironolactone therapy may reduce hair width in prepubertal girls with simple hypertrichosis, though its long-term efficacy and safety remain uncertain.
3 citations
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October 2019 in “Dermatologic Therapy” This article addresses the mechanisms of androgenic alopecia and seeks to clarify misconceptions, but it reports no new empirical findings and calls for further controlled studies.
2 citations
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January 2011 in “Andrologia” This study concluded that 16β-methyl-17α-benzoyloxypregnen-4-en-3,20-dione may be a promising treatment for androgen-dependent diseases and epilepsy due to its antioxidant effects and impact on GABAergic and serotonergic metabolism in rats.
1 citations
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May 2018 in “Journal of Evolution of medical and Dental Sciences” This study assessed the safety, efficacy, and feasibility of platelet-rich plasma injections in treating androgenetic alopecia, but it reports no clinical results.
1 citations
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December 1998 in “PubMed” In this case report, a 68-year-old woman with a Leydig cell tumor of the ovary experienced virilization, and surgical removal led to normalization of testosterone levels and regression of symptoms.
May 2025 in “Veterinary Medicine and Science” In this study, oral melatonin given to male Pomeranian dogs with Alopecia X improved semen quality and testicular blood flow in a dose-dependent manner, but altered hormonal balance, indicating complex effects that require further investigation for long-term implications.
January 2022 in “Turkiye Klinikleri Journal of Dermatology” This study found that the Turkish version of the Multidimensional Assessment of Interoceptive Awareness-2 Scale is valid and reliable for use with Turkish dermatology patients.