Hormonal Profile of Androgenetic Alopecia in Adolescents and Its Association With Metabolic Dysfunction: Single Center Retrospective Study

    September 2023 in “ Journal of The American Academy of Dermatology ”
    Sang Woo Ahn, Seung Hee Jang, Seong Min Hong, Jung Eun Seol, Hyo Jin Kim
    Image of study
    TLDR Adolescents with hair loss show different hormone levels by sex and often have related metabolic issues.
    The retrospective study investigated the clinical features and hormonal profile of Androgenetic alopecia (AGA) in adolescents. The study involved 21 subjects (8 boys and 13 girls) with a mean age of 16.1 years. The study found that 61.9% of the subjects had a family history of AGA. The most common symptom was diffuse thinning at the crown with frontal hairline preservation (61.9%). Acne was also present in 10 subjects. The hormonal profile showed normal total/free testosterone (T) and dehydroepiandrosterone sulfate (DHEA-S) in boys. However, 2 girls showed elevated total T and DHEA-S, while 5 girls only in DHEA-S. Nine subjects (3 boys and 6 girls) showed elevated random insulin or concurrent type 2 diabetes mellitus (DM). Five girls satisfied the Rotterdam criteria of PCOS. The study concluded that adolescents with AGA showed different androgen profiles between boys and girls, while concurrent metabolic dysfunction was observed similarly in both sexes. The study suggests that AGA in adolescents should be treated differently by their sex and distinguished from adults. Especially in girls, the features of hyperandrogenism and metabolic dysfunction should be carefully investigated.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community For those on TRT and suffer from a more aggressive type of (AGA) hairloss, what are your hair safe protocols?

      in Chat  6 upvotes 1 year ago
      People on testosterone replacement therapy (TRT) with aggressive androgenetic alopecia (AGA) discuss using Dutasteride or Finasteride, sometimes combined with topical treatments like RU58841 or CB-03-01 (Breezula), to prevent hair loss. Concerns about side effects and costs of certain treatments are mentioned, with one individual sharing their experience of slowed hair loss using Finasteride alone.

      community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

      in Research/Science  136 upvotes 7 months ago
      The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

      community AGA evaluation and first steps - BEGINNER MEGAPOST

      in Chat  73 upvotes 2 months ago
      The conversation discusses androgenic alopecia (AGA) and its treatments, focusing on finasteride, minoxidil, and ketoconazole shampoo. Finasteride is recommended as essential for preventing further hair loss.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

    Similar Research

    5 / 1000+ results