Study of the Therapeutic Potential of Metformin in Polycystic Ovary Syndrome: Focusing on Hyperandrogenism in a Sample of Iraqi Women

September 2025 in “ Scientific periodicals of Ukraine ”

Khudhur, Y.S., Khudhur, Sh.S.

metformin hyperandrogenism polycystic ovary syndrome testosterone luteinizing hormone follicle-stimulating hormone PCOS LH FSH

TLDR Metformin effectively reduces hormone levels in women with PCOS.

The study investigated the therapeutic potential of metformin in treating hyperandrogenism in 55 Iraqi women with polycystic ovary syndrome (PCOS). Participants, aged 18 to 45, took 500 mg of metformin twice daily for 3 months. Results showed significant reductions in serum levels of total and free testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) after treatment (p < 0.0001). The study concludes that metformin effectively reduces these hormone levels in PCOS patients, suggesting its potential benefit in managing the condition.

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