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    Glossary Topical JAK Inhibitors

    medications applied to skin to block Janus kinase enzymes

    Topical JAK Inhibitors, also known as Topical Janus Kinase Inhibitors or Topical JAKis, are medications applied directly to the skin to block the activity of Janus kinase enzymes. These enzymes play a role in the immune response and inflammation. By inhibiting them, these treatments can help manage conditions like alopecia areata, an autoimmune disorder that causes hair loss, by reducing inflammation and potentially promoting hair regrowth.

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    1. Emerging Topical and Systemic JAK Inhibitors in Dermatology Frontiers in Immunology · 2019 · 277 citations
    2. Topical Janus kinase inhibitors for the treatment of pediatric alopecia areata Journal of the American Academy of Dermatology · 2017 · 83 citations
    3. Topical Janus kinase inhibitors: A review of applications in dermatology Journal of the American Academy of Dermatology · 2018 · 63 citations
    4. Treatment of alopecia universalis with topical Janus kinase inhibitors – a double blind, placebo, and active controlled pilot study International Journal of Dermatology · 2018 · 49 citations
    5. Topical JAK Inhibitors for the Treatment of Alopecia Areata and Vitiligo Current dermatology reports · 2017
    6. 43647 Treatment of Refractory Folliculitis Decalvans with the Topical JAK Inhibitor Tofacitinib Journal of the American Academy of Dermatology · 2023
    7. Topical Application of a Protein Kinase C Inhibitor Reduces Skin and Hair Pigmentation 2004 · 60 citations
    8. Update on the use of topical calcineurin inhibitors in cutaneous lupus erythematosus Biologics: Targets & Therapy · 2011 · 9 citations
    9. Scalp atrophy secondary to steroid use in patients with scarring alopecia: are topical steroids superior to topical calcineurin inhibitors? International Journal of Dermatology · 2023 · 1 citations
    10. Review of the Literature: Topical JAK Inhibitors Showing Promise for Hair Loss! Hair transplant forum international · 2016
    11. The efficacy of topical minoxidil 2% versus topical botanically derived inhibitors of 5 alpha reductase in treatment of female pattern hair loss by trichoscopy Journal of the Egyptian Women's Dermatologic Society (Print) · 2019 · 1 citations
    12. 139 Anti-BCC efficacy of a topical hedgehog inhibitor without adverse effects in BCNS patients in a phase 2 randomized controlled trial 2018 · 1 citations
    13. A quantitative hair growth assessment in female androgenetic alopecia during one year, and its modulation by a topical 5?-reductase inhibitor Journal of The European Academy of Dermatology and Venereology · 1998
    14. 1072 Promotion of hair growth in normal mouse skin and alopecia areata by topical treatment of HDAC inhibitors 2018 · 1 citations
    15. Hair growth effects of oral administration of finasteride, a steroid 5 alpha-reductase inhibitor, alone and in combination with topical minoxidil in the balding stumptail macaque. The Journal of Clinical Endocrinology and Metabolism · 1992 · 34 citations
    16. Wound healing with topical BRAF inhibitor therapy in a diabetic model suggests tissue regenerative effects PLOS ONE · 2021 · 3 citations
    17. Comparative Efficacy of Oral and Topical 5-Alpha Reductase Inhibitors in Reducing Dihydrotestosterone levels across Men with Androgenetic Alopecia: A Network Meta-Analysis incorporating Post-Hoc Analyses of Randomized Clinical Trial Data Open Science Framework · 2026
    18. Topical Application of Aprepitant Inhibits Erlotinib-induced Facial Dermatitis/Hair Loss Journal of dermatology and skin science · 2024
    19. Oral and Topical Janus Kinase Inhibitors in Patients With Cutaneous T‐Cell Lymphoma: A Real‐World Single‐Center Experience The Journal of Dermatology · 2025
    20. 566 Staphylococcus epidermidis for the topical treatment of epidermal growth factor receptor (EGFR) inhibitor-induced dermal toxicity Journal of Investigative Dermatology · 2024
    21. Randomized Controlled Trial of the Topical Jak Inhibitor Delgocitinib Cream in Patients with Frontal Fibrosing Alopecia Journal of Investigative Dermatology · 2025 · 1 citations
    22. Tofacitinib 2% ointment, a topical Janus kinase inhibitor, for the treatment of alopecia areata: A pilot study of 10 patients Journal of the American Academy of Dermatology · 2017 · 48 citations
    23. Treatment of Epidermal Growth Factor Receptor Inhibitor-Induced Acneiform Eruption with Topical Recombinant Human Epidermal Growth Factor Dermatology · 2012 · 19 citations
    24. 708 Promotion of hair growth in alopecia areata by topical treatment of HDAC inhibitors 2019
    25. Topical MK-386 (M), an inhibitor of 5α-reductase (5αr) type I, suppresses sebum dht. Clinical Pharmacology & Therapeutics · 1996
    26. Selective induction of apoptosis in the hamster flank sebaceous gland organ by a topical liposome 5-α-reductase inhibitor: A treatment strategy for acne Journal of Dermatology · 2010 · 8 citations
    27. 711 Small molecule wnt pathway inhibitor (SM04755) as a potential topical psoriasis treatment Journal of Investigative Dermatology · 2017
    28. Clinical and Dermoscopic Evaluation of the Safety and Efficacy of Oral baricitinib (JAK Inhibitor) in Treatment of Localized Vitiligo Either Alone or with Topical Tacrolimus The Egyptian Journal of Hospital Medicine · 2025
    29. 126 Itch of Dermatomyositis treated with topical JAK inhibitor Journal of Investigative Dermatology · 2025
    30. Treatment of vitiligo with the topical Janus kinase inhibitor ruxolitinib: A 32-week open-label extension study with optional narrow-band ultraviolet B Journal of the American Academy of Dermatology · 2018 · 74 citations