Promotion of Hair Growth in Normal Mouse Skin and Alopecia Areata by Topical Treatment of HDAC Inhibitors

    April 2018 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    E. Wang, J. Chen, Angela M. Christiano
    TLDR HDAC inhibitors like Vorinostat and Entinostat may encourage hair regrowth and could be new treatments for hair loss conditions.
    The study investigated the effects of topical HDAC inhibitors on hair growth in normal mouse skin and in cases of alopecia areata. The results demonstrated that HDAC inhibitors significantly promoted hair growth in both normal and alopecia-affected mice. This suggested that HDAC inhibitors could be a potential therapeutic option for treating hair loss conditions. The findings were supported by observable increases in hair density and follicle size in treated areas compared to controls.
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