TLDR HDAC inhibitors like Vorinostat and Entinostat may encourage hair regrowth and could be new treatments for hair loss conditions.
The study investigated the effects of topical HDAC inhibitors on hair growth in normal mouse skin and in cases of alopecia areata. The results demonstrated that HDAC inhibitors significantly promoted hair growth in both normal and alopecia-affected mice. This suggested that HDAC inhibitors could be a potential therapeutic option for treating hair loss conditions. The findings were supported by observable increases in hair density and follicle size in treated areas compared to controls.
148 citations
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March 2019 in “Journal of autoimmunity” Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.
4 citations
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November 2018 in “JAAD case reports” Alopecia areata can sometimes appear as a straight line of hair loss instead of round patches.
May 2018 in “Journal of cosmetology & trichology” Combining platelet-rich plasma therapy with prostaglandin-F eye drops can significantly regrow hair in alopecia universalis.
110 citations
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December 2013 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” Alopecia areata is a genetic and immune-related hair loss condition that is often associated with other autoimmune diseases and does not typically cause permanent damage to hair follicles.
