April 2024 in “Human genomics” This study identified MPB susceptibility genes and potential drug candidates that may help uncover molecular mechanisms and address male-pattern baldness.
January 2024 in “Research Square (Research Square)” This study identified robust susceptibility genes and potential drug candidates for male-pattern baldness, providing insights into the condition's molecular mechanisms.
561 citations
,
April 2003 in “Journal of Investigative Dermatology” CD34 is a marker for isolating stem-like cells in mouse hair follicles.
10 citations
,
February 2019 in “Journal of Cellular Biochemistry” This study reports a complex network of blood lncRNA and associated pathways in alopecia areata but suggests further research is needed for verification and understanding of these findings.
72 citations
,
March 2013 in “Primates” In this study, the isotopic fractionation between tissues and diets of captive Japanese macaques was quantified, particularly noting hair's response to diet changes in controlled conditions, but these findings underscore the complexity of reconstructing long-term dietary history.
23 citations
,
January 2024 in “Nature Immunology” This study, using multimodal profiling in mice, found that various tissues contain unique γδ T cell subsets adapted to their environment, revealing their functional diversity, lineage relationships, and similarities to CD8+ tissue-resident memory T cells.
69 citations
,
February 2021 in “PLoS Computational Biology” This study found that securinine and ajmaline significantly inhibited hepatocellular carcinoma cell viability and induced apoptosis, with securinine showing lower toxicity to normal liver cells.
January 2026 in “Metabolites” This study analyzed gene expression profiles from multiple tissues to explore the molecular connections between obesity and immune-related processes, identifying potential links and pathways that may require further experimental validation to understand their roles in obesity fully.
July 2024 in “Journal of Investigative Dermatology”
10 citations
,
January 2013 in “Stem Cells and Development” This study suggests that dermal stem/progenitor cells can be enriched by intracellular granularity and display high proliferation and differentiation potential in vitro, distinguishing them from other fibroblasts and progenitors.
2 citations
,
December 2022 in “International journal of molecular sciences” This study compared RNA-seq results from horse plucked-hair and skin-biopsy samples, finding that plucked hairs were enriched with hair-follicle keratinocytes, while biopsies showed enrichment for other cell types.
166 citations
,
September 2011 in “The Journal of Cell Biology” This study found that the p63 transcription factor plays a role in epidermal morphogenesis by regulating Satb1 expression, impacting chromatin architecture and gene expression in epidermal progenitor cells.
49 citations
,
March 2017 in “PubMed” This review discusses the role of enhancers and super-enhancers in tissue-specific gene regulation and cancer development, and it reports no new experimental results.
99 citations
,
January 2014 in “Nature communications” In this study, researchers developed a method to differentiate human iPSCs into cells that can generate all lineages of hair follicles, potentially aiding treatments for hair loss and skin disorders.
August 2015 in “MOJ proteomics & bioinformatics” This study suggests that epithelial-derived pop-up keratinocytes (ePUKs) may improve regenerative medicine applications due to their specific phenotype and increased expression of proteins involved in regulating cellular movement and wound healing.
3 citations
,
May 2025 in “Cell Death and Disease” This study found that METTL1 is upregulated in papillary thyroid cancer tissues and promotes cancer cell proliferation and metastasis through its tRNA methyltransferase activity.
35 citations
,
May 2021 in “Nature communications” This study found that basement membrane components and structures in mouse hair follicles are highly specialized for specific inter-tissue interactions, with laminin α5 playing a crucial role in hair cycle regulation and anchoring.
In this study, researchers performed a genome-wide characterization of the Wnt gene family in domestic donkeys, identifying 19 genes and highlighting their evolutionary conservation among mammals, along with tissue-specific expression patterns potentially linked to reproductive regulation and tissue homeostasis.
This study found that while 3D spheroid culture preserved sweat gland cell-specific markers better than 2D culture, their growth and structural organization were suboptimal, highlighting the need for improved culture systems.
14 citations
,
May 2012 in “Endocrine Research” This study found diverse responses to the androgen dihydrotestosterone in rodent tissues, with most androgen-regulated processes being specific to particular tissues.
June 2023 in “Juan Cuevas eBooks” This volume is part of a series intended to educate plastic and reconstructive surgeons, residents, and other medical professionals, but the abstract does not report specific research findings.
2 citations
,
May 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that stem cells can temporarily act as non-professional phagocytes during hair cycle regeneration by clearing apoptotic cells through a process requiring local lipids and retinoids for activation, providing insights into their dual role in maintaining tissue integrity.
April 2024 in “The Journal of experimental medicine/The journal of experimental medicine” This review discusses how regulatory T cells, known for their immunosuppressive role, also produce repair mediators critical for tissue repair and regeneration, acting on non-immune cells in tissue-specific contexts, and highlights areas for future research in tissue repair, fibrosis, and cancer.
148 citations
,
April 2009 in “Molecular Pharmaceutics” This study reports that three synthesized PSMA-targeted radioimaging agents demonstrated high affinity and specific localization to prostate cancer tumors in a mouse model, highlighting their potential for cancer detection and monitoring.
9 citations
,
March 2013 in “Expert opinion on biological therapy” This article reviews recent research on adult epidermal stem cells, discussing their properties and potential for reprogramming into patient-specific therapies, and emphasizes the need for further development while minimizing cancer risk.
2 citations
,
February 2024 in “Nature cell biology” In this research, the authors identify coordinated mechanical forces as crucial for hair follicle development in mammals, with contractile, proliferative, and proteolytic activities facilitating the formation and sectioning of epithelial structures crucial for forming a functional tissue.
In a controlled study, researchers observed that lambs exposed to colder temperatures had increased wool growth, thicker skin, altered physiological traits, and activated specific molecular pathways, highlighting potential targets for enhancing cold tolerance, welfare, and productivity in sheep breeds.
437 citations
,
August 2014 in “Cell metabolism” This perspective suggests that browning agents may not directly enhance UCP1 expression in white adipose tissue but instead induce browning through increased heat loss, prompting thermogenesis to compensate.
66 citations
,
July 2015 in “Journal of Molecular Biology” This review discusses how macro-environmental factors such as intradermal adipose tissue and sex hormones influence hair and feather stem cell niches, suggesting environmental targets for regenerative medicine, but reports no new clinical results.
3 citations
,
January 2014 in “Elsevier eBooks” Different stem cells have benefits and challenges for tissue repair, and more research is needed to find the best types for each use.