METTL1-Mediated m7G tRNA Modification Drives Papillary Thyroid Cancer Progression and Metastasis by Regulating the Codon-Specific Translation of TNF-α

    May 2025 in “ Cell Death and Disease ”
    Weiwei Li, Ruiwang Xie, Huaying Chen, Junyu Lin, M. Zhong, Junsi Zhang, Shijun J. Zheng, Chun‐Yi Jiang, Xiangjin Chen, Sunwang Xu
    TLDR Targeting METTL1 may help slow papillary thyroid cancer growth and spread.
    The study investigates the role of METTL1-mediated m7G tRNA modification in papillary thyroid cancer (PTC). It finds that METTL1 is upregulated in PTC tissues and linked to poor prognosis. METTL1 promotes PTC cell proliferation and metastasis through its tRNA methyltransferase activity. Knockdown of METTL1 reduces m7G-modified tRNAs, affecting TNF-α translation, which is crucial for PTC progression. Supplementing TNF-α can partially reverse the effects of METTL1 deletion. The study suggests that targeting METTL1 could be a potential therapeutic strategy to inhibit PTC progression by reducing cell proliferation and metastasis.
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