28 citations
,
February 2014 in “PLoS ONE” This study reports that transplantation of an ESCs-collagen-chitin biomimetic membrane leads to successful in situ skin regeneration, including hair follicle cell proliferation and formation of dermatoglyphs, in nude mice with full-thickness skin defects.
70 citations
,
February 2021 in “International Journal of Molecular Sciences” This review provides an overview of current research on AD-MSCs, PRP, and biomaterials, highlighting their safety and efficacy in treating soft tissue defects and chronic wounds without major side effects.
December 2023 in “Medicine” This study observed that platelet-rich gel for scalp defect reconstruction was more cost-effective and less painful but resulted in poorer hair growth compared to the external tissue expansion technique.
49 citations
,
January 2017 in “Journal of Materials Chemistry B” This study developed a hydrogel from glycol chitosan and silica nanoparticles, which showed promise in wound healing by supporting microvessel and hair follicle growth in skin defects.
9 citations
,
May 2012 in “Journal of Craniofacial Surgery” This study reports that reconstructing perioral soft tissue defects with submental tissue resulted in satisfactory aesthetic outcomes and minimal donor-site morbidity.
7 citations
,
April 2017 in “Dermatologic surgery” This study concluded that bimatoprost 0.03%, applied either twice or once daily, is safe, well-tolerated, and effective in improving eyebrow fullness and darkness in individuals with eyebrow hypotrichosis.
August 2025 in “مجلة جامعة الحضارة للبحوث التطبيقية والإنسانية” This study conducted in Yemen involving 50 patients found that tissue expansion was effective for correcting scars and defects from post-burn and post-war injuries, achieving a 78% satisfaction rate with minimal complications.
4 citations
,
November 2015 in “Aesthetic Plastic Surgery” Using tissue expanders for scalp reconstruction in patients with extensive Aplasia Cutis Congenita is effective and has minimal complications.
11 citations
,
August 2013 in “Facial Plastic Surgery Clinics of North America” This article discusses the use of tissue expansion combined with older surgical techniques to repair large scalp defects and reports no new clinical results.
5 citations
,
July 2019 in “Atlas of the Oral and Maxillofacial Surgery Clinics” This article discusses challenges and limitations of using simple tissue mechanics for repairing head and neck skin defects in trauma and does not report new findings; it highlights potential problems with routine methods.
5 citations
,
August 2011 in “Dermatologic Surgery” Artificial dermis used for hair transplantation can reconstruct scalp defects effectively without the need for tissue expansion.
October 2022 in “Hair Transplantation” This review discusses techniques for repairing large scalp defects, emphasizing the combination of older methods like scalp reduction and tissue expansion with modern hair restoration surgery to achieve satisfactory results, despite challenges like compromised scalp viability due to factors like trauma or radiation.
December 2016 in “Journal of Pakistan Association of Dermatology” In this study, tissue expansion was identified as a safer initial procedure before hair transplantation for patients with large scalp defects, with the majority of participants having postburn scars and a mean expansion time of 33.6 days.
July 2012 in “Dermatologic Surgery” The author believes artificial dermis might not be the best first option for hair transplant surgeons when other surgical choices exist for scalp reconstruction.
480 citations
,
August 2014 in “Nature Biotechnology” This review discusses manipulating the stem cell niche as a strategy in regenerative medicine to repair damaged tissues, highlighting the potential benefits and challenges but reporting no new results.
This study suggests that the exercise-induced cytokine IL-15 can improve wound healing in aged skin, along with previously reported benefits on skin structure and mitochondrial function.
This chapter reviews secondary soft tissue revision surgeries for residual defects in patients with orofacial clefts, highlighting the various aesthetic issues and their surgical management after reaching skeletal maturity.
1 citations
,
August 2023 in “International Journal of Surgery Case Reports” In this study, free flaps, specifically the ALT-free tissue transfer, were found to be safe and reliable for reconstructing large scalp defects requiring both scalp and skull repairs, with consistent results observed in clinical applications.
8 citations
,
August 2019 in “ACR Open Rheumatology” This review explores the biomechanical factors and signaling systems, like Wnt, involved in the pathophysiology of psoriatic nail lesions and reports no new results.
In this retrospective analysis, researchers evaluated 54 patients undergoing soft tissue reconstruction for scalp and forehead defects and reported excellent aesthetic outcomes with local flaps for defects up to 50 cm², while larger defects typically required additional skin grafting.
1 citations
,
October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study demonstrated that intraoperative bioprinting using a bioink with human adipose-derived extracellular matrix and stem cells achieved successful reconstruction of full-thickness craniomaxillofacial skin defects in rats, promoting wound closure, adipogenesis, and hair follicle-like structure formation within two weeks.
1 citations
,
October 2008 in “PubMed” This review highlights advancements in skin tissue engineering in China over the past 20 years and reports no new clinical findings, noting future potential for artificial skin in burn treatment.
November 2010 in “PubMed” Human hair keratin can help repair fat tissue.
2 citations
,
November 2022 in “Scientific reports” This study found that gelatin sponges used as scaffolds in rats with deep wounds and periosteal defects enabled regeneration of diverse tissue types, including periosteum, skin, and appendages, highlighting the role of vascular niche formation.
February 2015 in “Journal of Biomedical Materials Research Part B: Applied Biomaterials” This study suggests that 4-META resin may be more effective than cyanoacrylate for promoting wound healing in rats, as the wounds were covered by epithelial tissue faster with 4-META resin.
September 2017 in “Journal of Investigative Dermatology” This study found that their novel 3D-imaging method, ASAXA-μCT, identified shrinkage of sweat glands as a key factor in skin aging, which leads to dermal defects, decreased elasticity, and increased wrinkling and sagging.
May 2005 in “Zhonghua chuangshang guke zazhi” This study found that human hair keratin bridges effectively induced nerve regeneration and demonstrated good biocompatibility and controlled degradation when used in rats with peripheral nerve defects.
January 2005 in “Zhonghua chuangshang guke zazhi” This study found that human hair keratin can effectively induce peripheral nerve regeneration in rats, showing good biocompatibility and a controllable degradation rate when used as a scaffold material.
2 citations
,
April 2014 in “International Wound Journal” The authors reported that V-Y-S plasty was a safe one-stage method for reconstructing very large scalp alopecia following burns or surgeries.
39 citations
,
April 2019 in “Journal of Biomaterials Science, Polymer Edition” This review discusses recent research and applications of RADA16 and RADA16-based peptide scaffolds in biomedicine, including their roles in tissue repair and drug delivery, but reports no new clinical results.