January 2011 in “Journal of pediatric endocrinology & metabolism/Journal of pediatric endocrinology and metabolism” This case study reported hyperandrogenism in non-obese triplet sisters with one sister's hyperthyroidism masking its clinical and biochemical signs until treatment increased her androgen levels and hirsutism.
11 citations
,
January 1973 in “BMJ” This study reported that cortisone, testosterone, and thyroxine replacement therapy increased energy and hair growth, while decreasing cold sensitivity, in the absence of tumor recurrence.
January 2008 in “Springer eBooks” Thyroid hormone may be useful for treating various skin conditions and needs more research.
January 2022 in “Clinical Cases in Dermatology” This paper reviews treatment options for alopecia in hypothyroidism, noting that while hormone replacement can restore hair growth, additional treatments like PRP and oral minoxidil may help, though further research is needed.
32 citations
,
September 2018 in “Clinical Obstetrics and Gynecology” This article states that hormone therapy with estrogens and antiandrogens for transgender females is within an obstetrician-gynecologist's practice scope and involves careful dosing and monitoring to manage short-term thrombotic risks.
7 citations
,
January 2022 in “Evidence-based complementary and alternative medicine” This study found that ginger supplementation significantly improved persistent hypothyroid symptoms and may aid in weight and lipid profile management in hypothyroid patients with normal TSH levels.
18 citations
,
June 2010 in “Current medicinal chemistry” This review discusses current treatment options for hirsutism, emphasizing the importance of combining therapies for better outcomes, but reports no new clinical findings.
24 citations
,
January 2001 in “Dermatologic clinics” This article reviews the use of hormonal therapies in dermatology, specifically focusing on their pathophysiologic rationale, indications, commonly used drugs, and pretreatment evaluations, and it reports no new research findings.
4 citations
,
January 1991 in “Journal of dermatological treatment” This study found that GnRH-A treatment significantly reduced hirsuties scores in women with mild idiopathic hirsuties but did not affect hair growth rate or diameter.
1 citations
,
December 2015 in “The Egyptian Journal of Histology” This study found that experimentally induced hypothyroidism in rats is associated with impaired skin structure, but topical application of triiodothyronine (T3) improved these changes to resemble normal skin.
85 citations
,
April 2004 in “Thyroid” This article emphasizes the importance of thyroid function monitoring and management in women, particularly for those planning pregnancy or postpartum, but reports no new clinical results.
209 citations
,
March 1998 in “Biochemical and biophysical research communications” This study identified a novel class of nonsteroidal ligands that can mimic the effects of dihydrotestosterone on androgen receptors, suggesting potential therapeutic applications in male fertility and hormone replacement therapy.
49 citations
,
December 1997 in “Urology” This study found that low-dose tamoxifen may effectively treat painful gynecomastia in patients receiving flutamide and finasteride for advanced prostate cancer.
September 2002 in “Research Repository (Kingston University London)” This review discusses strategies for treating hormone-dependent prostate diseases and synthesizes a range of potential 5α-reductase inhibitors, but experimental evaluation of these compounds was not completed.
This study synthesized new heterocyclic steroid derivatives and reported their promising antiproliferative activity against breast and prostate cancer cell lines, highlighting selectivity and impact on signaling pathways even in cells resistant to certain treatments.
23 citations
,
November 2007 in “Actas Dermo-Sifiliográficas” This study suggests that topical T3 can induce hair follicles to enter the growth phase and may reverse graying in mice, with in vitro results supporting enhanced hair shaft growth.
August 2026 in “Journal of Ayurveda and Integrated Medical Sciences” This case study of a 43-year-old woman with primary hypothyroidism found that an integrated Ayurvedic treatment over 20 weeks led to normalized thyroid function and relief of hypothyroid symptoms, highlighting Ayurvedic therapy's potential role in managing the condition.
22 citations
,
January 2001 in “Chemical & Pharmaceutical Bulletin” This study found that two new progesterone derivatives showed higher antiandrogenic effects and 5α-reductase inhibition than finasteride in hamsters, particularly reducing seminal vesicle weight and flank organ size.
2 citations
,
December 1994 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” This study concluded that a regimen of transdermal estradiol and oral medroxyprogesterone acetate effectively reduces hirsutism while minimizing side effects in women with polycystic ovary syndrome.
6 citations
,
November 2004 in “Bioorganic & Medicinal Chemistry Letters” This study found that arylhydantoin and arylthiohydantoin derivatives with hydroxybutyl or methyl side-chains showed superior androgen receptor binding affinity and may serve as promising radioiodinated AR ligands.
March 2018 in “Chin J Reprod Contracep” This review outlines chlormadinone acetate's contraceptive and non-contraceptive applications but reports no new clinical findings, emphasizing its potential in treating dysmenorrhea and androgen-related conditions.
April 2026 in “microPublication” In this study, researchers explored whether minoxidil, a common treatment for androgenetic alopecia, may have estrogenic activity and found preliminary evidence suggesting it could act as a partial agonist of Estrogen Receptor α (ERα).
12 citations
,
April 1995 in “Journal of Medicinal Chemistry” In this study, 4-substituted N-(1,1-dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides were synthesized and evaluated in vitro as potential 5 alpha-reductase inhibitors and antiandrogens.
September 2024 in “Complementary Medicine Research” Traditional Persian medicine helped a woman with resistant hyperthyroidism improve and stabilize her condition.
1 citations
,
January 1988 In this study, topical dehydroepiandrosterone (DHEA) doubled sebum production in women without systemic side effects, suggesting it may be a safe treatment for reduced sebum output related to menopause.
July 2026 in “Zenodo (CERN European Organization for Nuclear Research)” In this case report, an 11-year-old girl with hypothyroidism was found to have Hashimoto thyroiditis after presenting with hair loss, short stature, and pubertal disturbances; the study emphasizes the importance of early diagnosis and personalized thyroid hormone therapy for better outcomes.
10 citations
,
August 1998 in “Journal of Investigative Dermatology” This study observed that the compound EM-402 reduced 5α-reductase activity and sebaceous gland size in the flank organs and ears of hamsters, indicating potent localized anti-androgenic effects without systemic action.
10 citations
,
January 2000 in “PubMed” This study found that GnRH agonist treatment improved hirsutism scores more than finasteride after six months in women with idiopathic hirsutism, with both treatments causing no menstrual abnormalities or side-effects.
23 citations
,
January 2001 in “Chemical & Pharmaceutical Bulletin” This study found that several synthesized pregnane derivatives exhibited significant inhibitory effects on testosterone conversion to dihydrotestosterone and reduced related androgenic parameters in multiple pharmacological models.
March 2026 in “The Journal of Sexual Medicine” In this study, older women aged 70 and above, treated for sexual dysfunction using carefully monitored hormone therapy, reported improvements in sexual function and symptom relief, with no incidences of cancer or thromboembolic events, though some experienced breast tenderness and hair changes.