March 2026 in “The Journal of Sexual Medicine” In this study, older women aged 70 and above, treated for sexual dysfunction using carefully monitored hormone therapy, reported improvements in sexual function and symptom relief, with no incidences of cancer or thromboembolic events, though some experienced breast tenderness and hair changes.
164 citations
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January 2003 in “Drugs” 14 citations
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June 2011 in “Steroids” This study found that several dehydroepiandrosterone ester derivatives effectively reduced prostate and seminal vesicle weight in gonadectomized hamsters treated with testosterone, demonstrating potential antiandrogen effects comparable to Finasteride.
4 citations
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June 1990 in “Postgraduate medicine” This review highlights that pharmacologic therapy for hirsutism can effectively decrease hair growth, normalize menstrual cycles, and reduce endometrial cancer risk, with improvements in physical and mental well-being and minimal serious side effects reported.
20 citations
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September 2006 in “The Veterinary clinics of North America. Small animal practice/Veterinary clinics of North America. Small animal practice” This article reviews new drug therapies for endocrine disorders, discussing specific treatments such as trilostane for hyperadrenocorticism and various insulins for diabetes mellitus, but it reports no new clinical findings.
22 citations
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June 2005 in “Clinical Oncology” This case report documents an instance of symptomatic hypothyroidism developing in a patient with papillary thyroid carcinoma after beginning treatment with orlistat.
29 citations
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May 1975 in “Clinical Endocrinology” In this study, treatments combining betamethasone and anovulatory steroids significantly reduced testosterone production in women with hirsutism, with many reporting improved hirsutism and acne, although clinical benefit did not consistently correlate with testosterone reduction.
January 2026 in “Journal of Sexual and Mental Health” This study reports that two oral hormonal agents, dimethandrolone undecanoate and 11β-methylnortestosterone dodecylcarbonate, may effectively suppress hormones to contraceptive levels in men with mild side effects, though longer-term trials are required to confirm their safety and efficacy.
115 citations
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August 2008 in “The Journal of Clinical Endocrinology & Metabolism” In this study, T3 and T4 were found to directly influence human hair follicles in vitro, enhancing keratinocyte proliferation, prolonging the hair growth phase, and affecting pigmentation.
This meta-analysis found that combination oral contraceptive pills effectively treat hirsutism but recommends adding an antiandrogen if response is inadequate after six months.
8 citations
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March 1942 in “Journal of Endocrinology” This study found that growth in rats hindered by thyroid removal at birth can be normalized through the administration of thyroid preparations like thyroxine and artificial thyroprotein.
October 2025 in “Frontiers in Endocrinology” This study confirmed that methimazole use is associated with agranulocytosis, pyrexia, exposure during pregnancy, and hyperthyroidism, while also identifying new safety signals like premature birth and septic shock that require further investigation.
10 citations
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April 2006 in “Seminars in Reproductive Medicine” This article reviews the limited evidence on testosterone therapy for premenopausal women and notes a lack of long-term safety and effectiveness data for this population.
December 2019 in “REVISTA FIMCA” This review discusses the side effects of iodotherapy for thyroid cancer treatment, including various physical symptoms and impacts, and emphasizes the need for further research and pharmacological support; it reports no new experimental results.
May 1993 in “Drugs & Therapy Perspectives” Formestane is a preferred second-line treatment for advanced breast cancer in postmenopausal women because it's effective and has fewer side effects.
2 citations
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October 2024 in “JCEM Case Reports” This study describes a case of a 35-year-old woman who developed symptoms of hyperandrogenism and disrupted steroidogenesis due to chronic use of electronic cigarettes containing compounds similar to etomidate, despite no genetic mutation indicating 11β-hydroxylase deficiency.
49 citations
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October 1988 in “The Journal of Clinical Endocrinology & Metabolism” This study found that low doses of leuprolide effectively suppressed serum estradiol and LH response, while higher doses were needed to suppress testosterone and reduce hair growth in hirsute women.
1 citations
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January 2022 in “Open Journal of Endocrine and Metabolic Diseases” This case report describes a 70-year-old woman with pituitary resistance to thyroid hormone (PRTH) misdiagnosed as Graves disease, highlighting diagnostic challenges in managing this rare disorder.
This study found that a combination of spironolactone and oral contraceptive pills may improve hirsutism and hormonal profiles in women, although some experienced side effects such as persistent nausea.
May 2023 in “Frontiers in Endocrinology” This review article discusses recent updates on the skin manifestations associated with thyroid disease, emphasizing their role as early indicators of thyroid hormone dysregulation.
January 2019 in “Oncogen” This report suggests that for prostate cancer patients with cardiovascular disease, prescribing the GnRH antagonist degarelix may reduce cardiac events compared to using GnRH agonists, although prescribing should consider potential cardiac risks, particularly in patients with pre-existing conditions or older age.
7 citations
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September 2023 in “Cancer Treatment Reviews” This review highlights the possible impact of side effects from endocrine therapy on quality of life, emphasizing that these can lead to poor adherence and early treatment discontinuation in patients with hormone receptor positive early breast cancer, potentially worsening survival outcomes.
3 citations
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October 1993 in “Endocrinology” In this study, finasteride inhibited progesterone synthesis in mouse-derived MA-10 Leydig tumor cells by blocking cholesterol side-chain cleavage, but human and rat cells showed minimal sensitivity.
July 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This case report from a pediatric setting highlighted how an 11-year-old with Hashimoto thyroiditis experienced atypical manifestations such as short stature, pubertal issues, and hair loss after starting levothyroxine therapy, underscoring the need for early diagnosis and multidisciplinary care to improve health outcomes.
17 citations
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February 1989 in “Fertility and sterility” In this study, cimetidine at a daily dose of 1.5 gm for 3 months did not significantly affect hair growth in women with moderate to severe hirsutism.
November 2022 in “Journal of the Endocrine Society” This case study highlighted that excessive iodide intake from the supplement TauriNac was associated with the development of hypothyroidism in a cystic fibrosis patient, which reversed upon discontinuation.
77 citations
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October 1986 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” This study found that nafarelin treatment significantly reduced androgen levels and improved hirsutism symptoms in women, suggesting it may be useful for managing this condition.
December 2024 in “International Ayurvedic Medical Journal” This study observed that Ayurvedic treatments using Gandmala Kandan Rasa, Kanchanar Guggulu, and Varunadi Kwath provided symptomatic relief and reduced thyroid-stimulating hormone levels in a 35-year-old female patient with hypothyroidism over a 90-day period.
78 citations
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January 2000 in “Gynecological Endocrinology” This study found that the progestins norgestimate and dienogest may help treat clinical hyperandrogeny in women by inhibiting skin 5 alpha-reductase activity with minimal androgenic potential.
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December 2012 in “Critical Care Medicine” This case report describes a rare presentation of myxedema coma in a 46-year-old woman, initially identified by acute pulmonary embolism, which was managed successfully with thyroid hormone and corticosteroid treatment.