The study explores the synthesis of functionalized thiohydrazides for creating heterocyclic derivatives of steroids, which are significant in drug discovery due to their biological activity, particularly as anticancer agents for breast and prostate cancers. The research outlines a flexible synthetic approach to produce various steroid derivatives, including pyrazolines, thiadiazoles, thiadiazines, and pyridazines, with controlled heterocyclization patterns. The synthesized compounds demonstrated antiproliferative activity against cancer cell lines, with some lead compounds showing potent selectivity and significant effects on signaling pathways, even in tamoxifen-resistant cells.
27 citations
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March 2017 in “Current Clinical Pharmacology” Dutasteride is becoming a popular hair loss treatment, proving more effective than finasteride with similar side effects.
41 citations
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March 2007 in “Steroids” New methods to make oxasteroids show promise for medical treatments like osteoporosis and breast cancer.
37 citations
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October 2006 in “Steroids” New sulfur-containing steroid analogs show promise for more targeted medical treatments.
13 citations
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January 2015 in “Steroids” The study created a model to help design new inhibitors for steroidal 5α-reductase enzymes.
25 citations
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June 2002 in “Steroids” 4-azasteroids, including finasteride, can inhibit 5α-reductase, helping treat conditions like enlarged prostate and hair loss.
112 citations
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April 2009 in “Cochrane library” Spironolactone may reduce excessive hair growth in women but its effectiveness for acne is not supported.
